Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: Unraveling potential therapeutic avenues
<div><p>Obesity stands as a formidable global health challenge, predisposing individuals to a plethora of chronic illnesses such as cardiovascular disease, diabetes, and cancer. A confluence of genetic polymorphisms, suboptimal dietary choices, and sedentary lifestyles significantly cont...
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2024
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| _version_ | 1864513512941813760 |
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| author | Sara K. AlMarzooqi (18767743) |
| author2 | Fajr Almarzooqi (17345697) Hana Q. Sadida (15376385) Jayakumar Jerobin (6595520) Ikhlak Ahmed (150200) Abdul‐Badi Abou‐Samra (14779033) Khalid A. Fakhro (3158862) Punita Dhawan (158034) Ajaz A. Bhat (12984701) Ammira S. Al‐Shabeeb Akil (18767746) |
| author2_role | author author author author author author author author author |
| author_facet | Sara K. AlMarzooqi (18767743) Fajr Almarzooqi (17345697) Hana Q. Sadida (15376385) Jayakumar Jerobin (6595520) Ikhlak Ahmed (150200) Abdul‐Badi Abou‐Samra (14779033) Khalid A. Fakhro (3158862) Punita Dhawan (158034) Ajaz A. Bhat (12984701) Ammira S. Al‐Shabeeb Akil (18767746) |
| author_role | author |
| dc.creator.none.fl_str_mv | Sara K. AlMarzooqi (18767743) Fajr Almarzooqi (17345697) Hana Q. Sadida (15376385) Jayakumar Jerobin (6595520) Ikhlak Ahmed (150200) Abdul‐Badi Abou‐Samra (14779033) Khalid A. Fakhro (3158862) Punita Dhawan (158034) Ajaz A. Bhat (12984701) Ammira S. Al‐Shabeeb Akil (18767746) |
| dc.date.none.fl_str_mv | 2024-05-14T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1111/obr.13766 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Deciphering_the_complex_interplay_of_obesity_epithelial_barrier_dysfunction_and_tight_junction_remodeling_Unraveling_potential_therapeutic_avenues/25974379 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Engineering Biomedical engineering cancer cell proliferation claudins epithelial barrier function gene variants gut permeability inflammation obesity tight junction remodeling |
| dc.title.none.fl_str_mv | Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: Unraveling potential therapeutic avenues |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Obesity stands as a formidable global health challenge, predisposing individuals to a plethora of chronic illnesses such as cardiovascular disease, diabetes, and cancer. A confluence of genetic polymorphisms, suboptimal dietary choices, and sedentary lifestyles significantly contribute to the elevated incidence of obesity. This multifaceted health issue profoundly disrupts homeostatic equilibrium at both organismal and cellular levels, with marked alterations in gut permeability as a salient consequence. The intricate mechanisms underlying these alterations have yet to be fully elucidated. Still, evidence suggests that heightened inflammatory cytokine levels and the remodeling of tight junction (TJ) proteins, particularly claudins, play a pivotal role in the manifestation of epithelial barrier dysfunction in obesity. Strategic targeting of proteins implicated in these pathways and metabolites such as short‐chain fatty acids presents a promising intervention for restoring barrier functionality among individuals with obesity. Nonetheless, recognizing the heterogeneity among affected individuals is paramount; personalized medical interventions or dietary regimens tailored to specific genetic backgrounds and allergy profiles may prove indispensable. This comprehensive review delves into the nexus of obesity, tight junction remodeling, and barrier dysfunction, offering a critical appraisal of potential therapeutic interventions.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Obesity Reviews<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1111/obr.13766" target="_blank">https://dx.doi.org/10.1111/obr.13766</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_33ded1bbfd363f60abb149f838287e32 |
| identifier_str_mv | 10.1111/obr.13766 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25974379 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: Unraveling potential therapeutic avenuesSara K. AlMarzooqi (18767743)Fajr Almarzooqi (17345697)Hana Q. Sadida (15376385)Jayakumar Jerobin (6595520)Ikhlak Ahmed (150200)Abdul‐Badi Abou‐Samra (14779033)Khalid A. Fakhro (3158862)Punita Dhawan (158034)Ajaz A. Bhat (12984701)Ammira S. Al‐Shabeeb Akil (18767746)EngineeringBiomedical engineeringcancercell proliferationclaudinsepithelial barrier functiongene variantsgut permeabilityinflammationobesitytight junction remodeling<div><p>Obesity stands as a formidable global health challenge, predisposing individuals to a plethora of chronic illnesses such as cardiovascular disease, diabetes, and cancer. A confluence of genetic polymorphisms, suboptimal dietary choices, and sedentary lifestyles significantly contribute to the elevated incidence of obesity. This multifaceted health issue profoundly disrupts homeostatic equilibrium at both organismal and cellular levels, with marked alterations in gut permeability as a salient consequence. The intricate mechanisms underlying these alterations have yet to be fully elucidated. Still, evidence suggests that heightened inflammatory cytokine levels and the remodeling of tight junction (TJ) proteins, particularly claudins, play a pivotal role in the manifestation of epithelial barrier dysfunction in obesity. Strategic targeting of proteins implicated in these pathways and metabolites such as short‐chain fatty acids presents a promising intervention for restoring barrier functionality among individuals with obesity. Nonetheless, recognizing the heterogeneity among affected individuals is paramount; personalized medical interventions or dietary regimens tailored to specific genetic backgrounds and allergy profiles may prove indispensable. This comprehensive review delves into the nexus of obesity, tight junction remodeling, and barrier dysfunction, offering a critical appraisal of potential therapeutic interventions.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Obesity Reviews<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1111/obr.13766" target="_blank">https://dx.doi.org/10.1111/obr.13766</a></p>2024-05-14T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1111/obr.13766https://figshare.com/articles/journal_contribution/Deciphering_the_complex_interplay_of_obesity_epithelial_barrier_dysfunction_and_tight_junction_remodeling_Unraveling_potential_therapeutic_avenues/25974379CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/259743792024-05-14T03:00:00Z |
| spellingShingle | Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: Unraveling potential therapeutic avenues Sara K. AlMarzooqi (18767743) Engineering Biomedical engineering cancer cell proliferation claudins epithelial barrier function gene variants gut permeability inflammation obesity tight junction remodeling |
| status_str | publishedVersion |
| title | Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: Unraveling potential therapeutic avenues |
| title_full | Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: Unraveling potential therapeutic avenues |
| title_fullStr | Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: Unraveling potential therapeutic avenues |
| title_full_unstemmed | Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: Unraveling potential therapeutic avenues |
| title_short | Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: Unraveling potential therapeutic avenues |
| title_sort | Deciphering the complex interplay of obesity, epithelial barrier dysfunction, and tight junction remodeling: Unraveling potential therapeutic avenues |
| topic | Engineering Biomedical engineering cancer cell proliferation claudins epithelial barrier function gene variants gut permeability inflammation obesity tight junction remodeling |