Minor Intron Splicing from Basic Science to Disease
<p dir="ltr">Pre-mRNA splicing is an essential step in gene expression and is catalyzed by two machineries in eukaryotes: the major (U2 type) and minor (U12 type) spliceosomes. While the majority of introns in humans are U2 type, less than 0.4% are U12 type, also known as minor intro...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , |
| منشور في: |
2021
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513522180816896 |
|---|---|
| author | Ettaib El Marabti (23276158) |
| author2 | Joel Malek (3497978) Ihab Younis (57824) |
| author2_role | author author |
| author_facet | Ettaib El Marabti (23276158) Joel Malek (3497978) Ihab Younis (57824) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ettaib El Marabti (23276158) Joel Malek (3497978) Ihab Younis (57824) |
| dc.date.none.fl_str_mv | 2021-06-04T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/ijms22116062 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Minor_Intron_Splicing_from_Basic_Science_to_Disease/31444717 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Genetics minor introns U2 introns U12 introns minor spliceosome RNA splicing disease |
| dc.title.none.fl_str_mv | Minor Intron Splicing from Basic Science to Disease |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Pre-mRNA splicing is an essential step in gene expression and is catalyzed by two machineries in eukaryotes: the major (U2 type) and minor (U12 type) spliceosomes. While the majority of introns in humans are U2 type, less than 0.4% are U12 type, also known as minor introns (mi-INTs), and require a specialized spliceosome composed of U11, U12, U4atac, U5, and U6atac snRNPs. The high evolutionary conservation and apparent splicing inefficiency of U12 introns have set them apart from their major counterparts and led to speculations on the purpose for their existence. However, recent studies challenged the simple concept of mi-INTs splicing inefficiency due to low abundance of their spliceosome and confirmed their regulatory role in alternative splicing, significantly impacting the expression of their host genes. Additionally, a growing list of minor spliceosome-associated diseases with tissue-specific pathologies affirmed the importance of minor splicing as a key regulatory pathway, which when deregulated could lead to tissue-specific pathologies due to specific alterations in the expression of some minor-intron-containing genes. Consequently, uncovering how mi-INTs splicing is regulated in a tissue-specific manner would allow for better understanding of disease pathogenesis and pave the way for novel therapies, which we highlight in this review.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: International Journal of Molecular Sciences<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijms22116062" target="_blank">https://dx.doi.org/10.3390/ijms22116062</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_34294fec082036cd8f994b1022afdc1d |
| identifier_str_mv | 10.3390/ijms22116062 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/31444717 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Minor Intron Splicing from Basic Science to DiseaseEttaib El Marabti (23276158)Joel Malek (3497978)Ihab Younis (57824)Biological sciencesBiochemistry and cell biologyGeneticsminor intronsU2 intronsU12 intronsminor spliceosomeRNA splicingdisease<p dir="ltr">Pre-mRNA splicing is an essential step in gene expression and is catalyzed by two machineries in eukaryotes: the major (U2 type) and minor (U12 type) spliceosomes. While the majority of introns in humans are U2 type, less than 0.4% are U12 type, also known as minor introns (mi-INTs), and require a specialized spliceosome composed of U11, U12, U4atac, U5, and U6atac snRNPs. The high evolutionary conservation and apparent splicing inefficiency of U12 introns have set them apart from their major counterparts and led to speculations on the purpose for their existence. However, recent studies challenged the simple concept of mi-INTs splicing inefficiency due to low abundance of their spliceosome and confirmed their regulatory role in alternative splicing, significantly impacting the expression of their host genes. Additionally, a growing list of minor spliceosome-associated diseases with tissue-specific pathologies affirmed the importance of minor splicing as a key regulatory pathway, which when deregulated could lead to tissue-specific pathologies due to specific alterations in the expression of some minor-intron-containing genes. Consequently, uncovering how mi-INTs splicing is regulated in a tissue-specific manner would allow for better understanding of disease pathogenesis and pave the way for novel therapies, which we highlight in this review.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: International Journal of Molecular Sciences<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijms22116062" target="_blank">https://dx.doi.org/10.3390/ijms22116062</a></p>2021-06-04T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/ijms22116062https://figshare.com/articles/journal_contribution/Minor_Intron_Splicing_from_Basic_Science_to_Disease/31444717CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/314447172021-06-04T03:00:00Z |
| spellingShingle | Minor Intron Splicing from Basic Science to Disease Ettaib El Marabti (23276158) Biological sciences Biochemistry and cell biology Genetics minor introns U2 introns U12 introns minor spliceosome RNA splicing disease |
| status_str | publishedVersion |
| title | Minor Intron Splicing from Basic Science to Disease |
| title_full | Minor Intron Splicing from Basic Science to Disease |
| title_fullStr | Minor Intron Splicing from Basic Science to Disease |
| title_full_unstemmed | Minor Intron Splicing from Basic Science to Disease |
| title_short | Minor Intron Splicing from Basic Science to Disease |
| title_sort | Minor Intron Splicing from Basic Science to Disease |
| topic | Biological sciences Biochemistry and cell biology Genetics minor introns U2 introns U12 introns minor spliceosome RNA splicing disease |