Hepato‐splanchnic fluxes during exercise in patients with cirrhosis—a pilot study
<p dir="ltr">In cirrhotic patients, compromised hepatocyte function combined with disturbed hepatic blood flow could affect hepato‐splanchnic substrate and metabolite fluxes and exacerbate fatigue during exercise. Eight cirrhotic patients performed incremental cycling trials (3 × 10...
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| مؤلفون آخرون: | , , , |
| منشور في: |
2024
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| _version_ | 1864513540465885184 |
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| author | Stefanos Volianitis (22155835) |
| author2 | Niels H. Secher (3262710) Otto Clemmesen (22155838) Peter Ott (4730562) Henning Bay Nielsen (18792762) |
| author2_role | author author author author |
| author_facet | Stefanos Volianitis (22155835) Niels H. Secher (3262710) Otto Clemmesen (22155838) Peter Ott (4730562) Henning Bay Nielsen (18792762) |
| author_role | author |
| dc.creator.none.fl_str_mv | Stefanos Volianitis (22155835) Niels H. Secher (3262710) Otto Clemmesen (22155838) Peter Ott (4730562) Henning Bay Nielsen (18792762) |
| dc.date.none.fl_str_mv | 2024-09-25T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.14814/phy2.16162 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Hepato_splanchnic_fluxes_during_exercise_in_patients_with_cirrhosis_a_pilot_study/30024289 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics ammonia uptake glucose release lactate elimination liver blood flow oxygen uptake |
| dc.title.none.fl_str_mv | Hepato‐splanchnic fluxes during exercise in patients with cirrhosis—a pilot study |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">In cirrhotic patients, compromised hepatocyte function combined with disturbed hepatic blood flow could affect hepato‐splanchnic substrate and metabolite fluxes and exacerbate fatigue during exercise. Eight cirrhotic patients performed incremental cycling trials (3 × 10 min; at light (28 [19–37] W; median with range), moderate (55 [41–69] W), and vigorous (76 [50–102] W) intensity). Heart rate increased from 68 (62–74) at rest to 95 (90–100), 114 (108–120), and 140 (134–146) beats/min (<i>P</i> < 0.05), respectively. The hepatic blood flow, as determined by constant infusion of indocyanine green with arterial and hepatic venous sampling, declined from 1.01 (0.75–1.27) to 0.69 (0.47–0.91) L/min (<i>P</i> < 0.05). Hepatic glucose output increased from 0.6 (0.5–0.7) to 1.5 (1.3–1.7) mmol/min, while arterial lactate increased from 0.8 (0.7–0.9) to 9.0 (8.1–9.9) mmol/L (<i>P</i> < 0.05) despite a rise in hepatic lactate uptake. Arterial ammonia increased in parallel to lactate from 47.3 (40.1–54.5) to 144.4 (120.5–168.3) μmol/L (<i>P</i> < 0.05), although hepatic ammonia uptake increased from 19.5 (12.4–26.6) to 69.5 (46.5–92.5) μmol/min (<i>P</i> < 0.05). Among the 14 amino acids measured, glutamate was released in the liver, while the uptake of free fatty acids decreased. During exercise at relatively low workloads, arterial lactate and ammonia levels were comparable to those seen in healthy subjects at higher workloads, while euglycemia was maintained due to sufficient hepatic glucose production. The accumulation of lactate and ammonia may contribute to exercise intolerance in patients with cirrhosis.</p><h2>Other Information</h2><p dir="ltr">Published in: Physiological Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.14814/phy2.16162" target="_blank">https://dx.doi.org/10.14814/phy2.16162</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_343516f81da1941d653f0d19c5d297fa |
| identifier_str_mv | 10.14814/phy2.16162 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30024289 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Hepato‐splanchnic fluxes during exercise in patients with cirrhosis—a pilot studyStefanos Volianitis (22155835)Niels H. Secher (3262710)Otto Clemmesen (22155838)Peter Ott (4730562)Henning Bay Nielsen (18792762)Biomedical and clinical sciencesClinical sciencesMedical biochemistry and metabolomicsammonia uptakeglucose releaselactate eliminationliver blood flowoxygen uptake<p dir="ltr">In cirrhotic patients, compromised hepatocyte function combined with disturbed hepatic blood flow could affect hepato‐splanchnic substrate and metabolite fluxes and exacerbate fatigue during exercise. Eight cirrhotic patients performed incremental cycling trials (3 × 10 min; at light (28 [19–37] W; median with range), moderate (55 [41–69] W), and vigorous (76 [50–102] W) intensity). Heart rate increased from 68 (62–74) at rest to 95 (90–100), 114 (108–120), and 140 (134–146) beats/min (<i>P</i> < 0.05), respectively. The hepatic blood flow, as determined by constant infusion of indocyanine green with arterial and hepatic venous sampling, declined from 1.01 (0.75–1.27) to 0.69 (0.47–0.91) L/min (<i>P</i> < 0.05). Hepatic glucose output increased from 0.6 (0.5–0.7) to 1.5 (1.3–1.7) mmol/min, while arterial lactate increased from 0.8 (0.7–0.9) to 9.0 (8.1–9.9) mmol/L (<i>P</i> < 0.05) despite a rise in hepatic lactate uptake. Arterial ammonia increased in parallel to lactate from 47.3 (40.1–54.5) to 144.4 (120.5–168.3) μmol/L (<i>P</i> < 0.05), although hepatic ammonia uptake increased from 19.5 (12.4–26.6) to 69.5 (46.5–92.5) μmol/min (<i>P</i> < 0.05). Among the 14 amino acids measured, glutamate was released in the liver, while the uptake of free fatty acids decreased. During exercise at relatively low workloads, arterial lactate and ammonia levels were comparable to those seen in healthy subjects at higher workloads, while euglycemia was maintained due to sufficient hepatic glucose production. The accumulation of lactate and ammonia may contribute to exercise intolerance in patients with cirrhosis.</p><h2>Other Information</h2><p dir="ltr">Published in: Physiological Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.14814/phy2.16162" target="_blank">https://dx.doi.org/10.14814/phy2.16162</a></p>2024-09-25T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.14814/phy2.16162https://figshare.com/articles/journal_contribution/Hepato_splanchnic_fluxes_during_exercise_in_patients_with_cirrhosis_a_pilot_study/30024289CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/300242892024-09-25T09:00:00Z |
| spellingShingle | Hepato‐splanchnic fluxes during exercise in patients with cirrhosis—a pilot study Stefanos Volianitis (22155835) Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics ammonia uptake glucose release lactate elimination liver blood flow oxygen uptake |
| status_str | publishedVersion |
| title | Hepato‐splanchnic fluxes during exercise in patients with cirrhosis—a pilot study |
| title_full | Hepato‐splanchnic fluxes during exercise in patients with cirrhosis—a pilot study |
| title_fullStr | Hepato‐splanchnic fluxes during exercise in patients with cirrhosis—a pilot study |
| title_full_unstemmed | Hepato‐splanchnic fluxes during exercise in patients with cirrhosis—a pilot study |
| title_short | Hepato‐splanchnic fluxes during exercise in patients with cirrhosis—a pilot study |
| title_sort | Hepato‐splanchnic fluxes during exercise in patients with cirrhosis—a pilot study |
| topic | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics ammonia uptake glucose release lactate elimination liver blood flow oxygen uptake |