Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope
<p dir="ltr">Boronic acids/esters have recently emerged in the field of medicinal and pharmaceutical research due to their exceptional oxophilicity, low toxicity, and unique structure. They are known as potent enzyme inhibitors, cancer therapy capture agents, and can mimic certain ty...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , , , , , , , , |
| منشور في: |
2023
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513527978393600 |
|---|---|
| author | Mothana K. Al-Omari (17917706) |
| author2 | Mai Elaarag (17807390) Raed M. Al-Zoubi (2037490) Ahmad R. Al-Qudimat (17337808) Ayman A. Zarour (17917709) Enas A. Al-Hurani (17917712) Zainab E. Fares (17917715) Leena M. Alkharraz (17917718) Mohanad Shkoor (3768385) Abdulilah D. Bani-Yaseen (17917721) Omar M. Aboumarzouk (14779240) Aksam Yassin (14779204) Abdulla A. Al-Ansari (17917724) |
| author2_role | author author author author author author author author author author author author |
| author_facet | Mothana K. Al-Omari (17917706) Mai Elaarag (17807390) Raed M. Al-Zoubi (2037490) Ahmad R. Al-Qudimat (17337808) Ayman A. Zarour (17917709) Enas A. Al-Hurani (17917712) Zainab E. Fares (17917715) Leena M. Alkharraz (17917718) Mohanad Shkoor (3768385) Abdulilah D. Bani-Yaseen (17917721) Omar M. Aboumarzouk (14779240) Aksam Yassin (14779204) Abdulla A. Al-Ansari (17917724) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mothana K. Al-Omari (17917706) Mai Elaarag (17807390) Raed M. Al-Zoubi (2037490) Ahmad R. Al-Qudimat (17337808) Ayman A. Zarour (17917709) Enas A. Al-Hurani (17917712) Zainab E. Fares (17917715) Leena M. Alkharraz (17917718) Mohanad Shkoor (3768385) Abdulilah D. Bani-Yaseen (17917721) Omar M. Aboumarzouk (14779240) Aksam Yassin (14779204) Abdulla A. Al-Ansari (17917724) |
| dc.date.none.fl_str_mv | 2023-06-15T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1080/14756366.2023.2220084 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Organoboronic_acids_esters_as_effective_drug_and_prodrug_candidates_in_cancer_treatments_challenge_and_hope/25160207 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Chemical sciences Medicinal and biomolecular chemistry Boronic acid cancer disease enzyme inhibitor mechanism drug |
| dc.title.none.fl_str_mv | Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Boronic acids/esters have recently emerged in the field of medicinal and pharmaceutical research due to their exceptional oxophilicity, low toxicity, and unique structure. They are known as potent enzyme inhibitors, cancer therapy capture agents, and can mimic certain types of antibodies to fight infections. They have been designed and developed into drugs, and this approach has emerged in the last 20 years. Five boronic acid drugs have been approved by the FDA and Health Canada, two of which are used to treat cancer, specifically multiple myeloma. The purpose of this review is to investigate boronic acid/ester derivatives as potential pharmaceutical agents as well as the mechanism of action. It will concentrate on six types of cancer: multiple myeloma, prostate cancer, breast cancer, lung cancer, cervical cancer, and colon cancer. Some newly developed boron-containing compounds have already demonstrated highly promising activities, but further investigation is required before final conclusions can be drawn.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Enzyme Inhibition and Medicinal Chemistry<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1080/14756366.2023.2220084" target="_blank">https://dx.doi.org/10.1080/14756366.2023.2220084</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_343dc5c6a94ae40a147bb7279bd5d034 |
| identifier_str_mv | 10.1080/14756366.2023.2220084 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25160207 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hopeMothana K. Al-Omari (17917706)Mai Elaarag (17807390)Raed M. Al-Zoubi (2037490)Ahmad R. Al-Qudimat (17337808)Ayman A. Zarour (17917709)Enas A. Al-Hurani (17917712)Zainab E. Fares (17917715)Leena M. Alkharraz (17917718)Mohanad Shkoor (3768385)Abdulilah D. Bani-Yaseen (17917721)Omar M. Aboumarzouk (14779240)Aksam Yassin (14779204)Abdulla A. Al-Ansari (17917724)Biomedical and clinical sciencesClinical sciencesOncology and carcinogenesisPharmacology and pharmaceutical sciencesChemical sciencesMedicinal and biomolecular chemistryBoronic acidcancer diseaseenzyme inhibitormechanismdrug<p dir="ltr">Boronic acids/esters have recently emerged in the field of medicinal and pharmaceutical research due to their exceptional oxophilicity, low toxicity, and unique structure. They are known as potent enzyme inhibitors, cancer therapy capture agents, and can mimic certain types of antibodies to fight infections. They have been designed and developed into drugs, and this approach has emerged in the last 20 years. Five boronic acid drugs have been approved by the FDA and Health Canada, two of which are used to treat cancer, specifically multiple myeloma. The purpose of this review is to investigate boronic acid/ester derivatives as potential pharmaceutical agents as well as the mechanism of action. It will concentrate on six types of cancer: multiple myeloma, prostate cancer, breast cancer, lung cancer, cervical cancer, and colon cancer. Some newly developed boron-containing compounds have already demonstrated highly promising activities, but further investigation is required before final conclusions can be drawn.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Enzyme Inhibition and Medicinal Chemistry<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1080/14756366.2023.2220084" target="_blank">https://dx.doi.org/10.1080/14756366.2023.2220084</a></p>2023-06-15T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1080/14756366.2023.2220084https://figshare.com/articles/journal_contribution/Organoboronic_acids_esters_as_effective_drug_and_prodrug_candidates_in_cancer_treatments_challenge_and_hope/25160207CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/251602072023-06-15T03:00:00Z |
| spellingShingle | Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope Mothana K. Al-Omari (17917706) Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Chemical sciences Medicinal and biomolecular chemistry Boronic acid cancer disease enzyme inhibitor mechanism drug |
| status_str | publishedVersion |
| title | Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope |
| title_full | Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope |
| title_fullStr | Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope |
| title_full_unstemmed | Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope |
| title_short | Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope |
| title_sort | Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope |
| topic | Biomedical and clinical sciences Clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Chemical sciences Medicinal and biomolecular chemistry Boronic acid cancer disease enzyme inhibitor mechanism drug |