Ventilator-associated pneumonia diagnosis: electrochemical sensors for rapid and sensitive detection of <i>pyocyanin</i>
<p dir="ltr">Ventilator-associated pneumonia (VAP) is a severe condition in critically ill patients that requires timely diagnosis to improve patient outcomes. In this study, we developed an electrochemical sensor for <i>pyocyanin</i> detection using a TiO<sub>2<...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , |
| منشور في: |
2024
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| الموضوعات: | |
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| الملخص: | <p dir="ltr">Ventilator-associated pneumonia (VAP) is a severe condition in critically ill patients that requires timely diagnosis to improve patient outcomes. In this study, we developed an electrochemical sensor for <i>pyocyanin</i> detection using a TiO<sub>2</sub>-NiO-rGO catalyst and found that it could detect the concentration of <i>pyocyanin</i> required for mimicking the throat trachea’s environment (LOD: 0.2 g/mL). We also investigated using DNA aptamer for detecting <i>pyocyanin</i>, a biomarker of <i>Pseudomonas aeruginosa</i>, a common causative agent of VAP. Our findings suggest that the TiO<sub>2</sub>-NiO-rGO catalyst without aptamer could provide a rapid and cost-effective diagnostic tool for VAP, and the electrochemical sensor has the potential to be made disposable for in vivo applications. Using the TiO<sub>2</sub>-NiO-rGO catalyst offers synergistic effects that enhance the detection process’s overall electrochemical performance, sensitivity, and selectivity. This work’s results demonstrate that electrochemical detection of <i>pyocyanin</i> using a TiO-NiO<sub>2</sub>-rGO catalyst holds great potential for various applications, such as clinical diagnostics and drug discovery. Further research and optimization of the catalyst composition, morphology, and surface modifications can contribute to advancing this pyocyanin electrochemical detection approach.</p><h2>Other Information</h2><p dir="ltr">Published in: Emergent Materials<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s42247-024-00683-4" target="_blank">https://dx.doi.org/10.1007/s42247-024-00683-4</a></p> |
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