Unmasking Aspergillosis: A Rare Cause of Facial Palsy and Vision Loss in an Immunocompetent Patient—A Case Report and Literature Review
<p dir="ltr">We present a case report of a 45‐year‐old female with acute onset right‐sided facial weakness, worsening vision, and diplopia. Upon evaluation, the patient exhibited total right‐side facial palsy (House‐Brackmann grade IV) with III, IV, and VI Cranial Nerve Ophthalmopleg...
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2025
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| _version_ | 1864513538089811968 |
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| author | Abdur Rehman (11154) |
| author2 | Hafiz Anzal Farooqi (22330516) Imran Khan (109715) Fatima Akram (22330519) Basit Ali Khan (22330522) Arham Ihtesham (22225537) Shahzaib Maqbool (21842465) Javed Iqbal (2121922) |
| author2_role | author author author author author author author |
| author_facet | Abdur Rehman (11154) Hafiz Anzal Farooqi (22330516) Imran Khan (109715) Fatima Akram (22330519) Basit Ali Khan (22330522) Arham Ihtesham (22225537) Shahzaib Maqbool (21842465) Javed Iqbal (2121922) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abdur Rehman (11154) Hafiz Anzal Farooqi (22330516) Imran Khan (109715) Fatima Akram (22330519) Basit Ali Khan (22330522) Arham Ihtesham (22225537) Shahzaib Maqbool (21842465) Javed Iqbal (2121922) |
| dc.date.none.fl_str_mv | 2025-02-05T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/ccr3.70152 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Unmasking_Aspergillosis_A_Rare_Cause_of_Facial_Palsy_and_Vision_Loss_in_an_Immunocompetent_Patient_A_Case_Report_and_Literature_Review/30233983 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Immunology Neurosciences Aspergillus facial palsy sphenoid sinus vision loss voriconazole |
| dc.title.none.fl_str_mv | Unmasking Aspergillosis: A Rare Cause of Facial Palsy and Vision Loss in an Immunocompetent Patient—A Case Report and Literature Review |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">We present a case report of a 45‐year‐old female with acute onset right‐sided facial weakness, worsening vision, and diplopia. Upon evaluation, the patient exhibited total right‐side facial palsy (House‐Brackmann grade IV) with III, IV, and VI Cranial Nerve Ophthalmoplegia. There was no perception of light associated with optic atrophy on ocular examination. Computed tomography and magnetic resonance imaging showed a sizeable sphenoid sinus mass compressing the right optic nerve, consistent with neoplasia or invasive fungal infection. Eventually, we removed the mass endoscopically through a transnasal approach and diagnosed it as invasive Aspergillosis on histopathological examination, even though no previous record of immunodeficiency existed. The patient received intravenous followed by oral voriconazole. Postoperatively, there was partial recovery of her facial nerve function. This case highlights the importance of considering invasive fungal infections, even in immunocompetent patients, when managing space‐occupying lesions with neuro‐ophthalmic involvement.</p><h2>Other Information</h2><p dir="ltr">Published in: Clinical Case Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/ccr3.70152" target="_blank">https://dx.doi.org/10.1002/ccr3.70152</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_366169b9744fd0195826ba69bb7e12f4 |
| identifier_str_mv | 10.1002/ccr3.70152 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30233983 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Unmasking Aspergillosis: A Rare Cause of Facial Palsy and Vision Loss in an Immunocompetent Patient—A Case Report and Literature ReviewAbdur Rehman (11154)Hafiz Anzal Farooqi (22330516)Imran Khan (109715)Fatima Akram (22330519)Basit Ali Khan (22330522)Arham Ihtesham (22225537)Shahzaib Maqbool (21842465)Javed Iqbal (2121922)Biomedical and clinical sciencesImmunologyNeurosciencesAspergillusfacial palsysphenoid sinusvision lossvoriconazole<p dir="ltr">We present a case report of a 45‐year‐old female with acute onset right‐sided facial weakness, worsening vision, and diplopia. Upon evaluation, the patient exhibited total right‐side facial palsy (House‐Brackmann grade IV) with III, IV, and VI Cranial Nerve Ophthalmoplegia. There was no perception of light associated with optic atrophy on ocular examination. Computed tomography and magnetic resonance imaging showed a sizeable sphenoid sinus mass compressing the right optic nerve, consistent with neoplasia or invasive fungal infection. Eventually, we removed the mass endoscopically through a transnasal approach and diagnosed it as invasive Aspergillosis on histopathological examination, even though no previous record of immunodeficiency existed. The patient received intravenous followed by oral voriconazole. Postoperatively, there was partial recovery of her facial nerve function. This case highlights the importance of considering invasive fungal infections, even in immunocompetent patients, when managing space‐occupying lesions with neuro‐ophthalmic involvement.</p><h2>Other Information</h2><p dir="ltr">Published in: Clinical Case Reports<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1002/ccr3.70152" target="_blank">https://dx.doi.org/10.1002/ccr3.70152</a></p>2025-02-05T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/ccr3.70152https://figshare.com/articles/journal_contribution/Unmasking_Aspergillosis_A_Rare_Cause_of_Facial_Palsy_and_Vision_Loss_in_an_Immunocompetent_Patient_A_Case_Report_and_Literature_Review/30233983CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/302339832025-02-05T03:00:00Z |
| spellingShingle | Unmasking Aspergillosis: A Rare Cause of Facial Palsy and Vision Loss in an Immunocompetent Patient—A Case Report and Literature Review Abdur Rehman (11154) Biomedical and clinical sciences Immunology Neurosciences Aspergillus facial palsy sphenoid sinus vision loss voriconazole |
| status_str | publishedVersion |
| title | Unmasking Aspergillosis: A Rare Cause of Facial Palsy and Vision Loss in an Immunocompetent Patient—A Case Report and Literature Review |
| title_full | Unmasking Aspergillosis: A Rare Cause of Facial Palsy and Vision Loss in an Immunocompetent Patient—A Case Report and Literature Review |
| title_fullStr | Unmasking Aspergillosis: A Rare Cause of Facial Palsy and Vision Loss in an Immunocompetent Patient—A Case Report and Literature Review |
| title_full_unstemmed | Unmasking Aspergillosis: A Rare Cause of Facial Palsy and Vision Loss in an Immunocompetent Patient—A Case Report and Literature Review |
| title_short | Unmasking Aspergillosis: A Rare Cause of Facial Palsy and Vision Loss in an Immunocompetent Patient—A Case Report and Literature Review |
| title_sort | Unmasking Aspergillosis: A Rare Cause of Facial Palsy and Vision Loss in an Immunocompetent Patient—A Case Report and Literature Review |
| topic | Biomedical and clinical sciences Immunology Neurosciences Aspergillus facial palsy sphenoid sinus vision loss voriconazole |