Tranexamic acid for the management of hematuria: A systematic review
<h3 dir="ltr">Objective</h3><p dir="ltr">To evaluate TXA’s efficacy in managing hematuria and synthesize current evidence to guide urological practice. </p><h3 dir="ltr">Methods</h3><p dir="ltr">This systematic review...
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2025
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| _version_ | 1864513524385972224 |
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| author | Lina Naseralallah (14146465) |
| author2 | Dima Nasrallah (22225495) Raneem Alsheikh (20644332) Deemah Assami (22225492) Rawan Boudaka (22963528) |
| author2_role | author author author author |
| author_facet | Lina Naseralallah (14146465) Dima Nasrallah (22225495) Raneem Alsheikh (20644332) Deemah Assami (22225492) Rawan Boudaka (22963528) |
| author_role | author |
| dc.creator.none.fl_str_mv | Lina Naseralallah (14146465) Dima Nasrallah (22225495) Raneem Alsheikh (20644332) Deemah Assami (22225492) Rawan Boudaka (22963528) |
| dc.date.none.fl_str_mv | 2025-12-26T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.urology.2025.12.035 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Tranexamic_acid_for_the_management_of_hematuria_A_systematic_review/31017820 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Tranexamic acid (TXA) Hematuria Urology Antifibrinolytic agents Postoperative bleeding |
| dc.title.none.fl_str_mv | Tranexamic acid for the management of hematuria: A systematic review |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3 dir="ltr">Objective</h3><p dir="ltr">To evaluate TXA’s efficacy in managing hematuria and synthesize current evidence to guide urological practice. </p><h3 dir="ltr">Methods</h3><p dir="ltr">This systematic review followed PRISMA 2020 guidelines and was registered in PROSPERO (CRD42022335404). We searched four databases, including PubMed, EMBASE, CINAHL, and Cochrane, for studies on TXA use in adults with hematuria with either interventional or observational designs. Data extraction and quality assessment were performed independently by two reviewers, and findings were summarized using a narrative synthesis. </p><h3 dir="ltr">Results</h3><p dir="ltr">The search yielded 227 records, of which seven studies (970 participants) met inclusion criteria. Four trials on postoperative hematuria showed that tranexamic acid (TXA)—particularly intravenous—consistently reduced hemoglobin decline and blood loss. Three studies on non-postoperative hematuria demonstrated reductions in visible hematuria and symptom duration, though effects on transfusion and laboratory outcomes were variable. All administration routes—intravenous, oral, and intravesical irrigation—were effective; however, IV TXA showed superior outcomes in postoperative cases, while oral and irrigation routes appeared more advantageous in non-surgical settings. </p><h3 dir="ltr">Conclusion</h3><p dir="ltr">TXA is effective in reducing both postoperative and non-postoperative hematuria, supporting its expanded use in urological practice. However, larger, high-quality studies are needed to confirm these findings and refine treatment protocols.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Urology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.urology.2025.12.035" target="_blank">https://dx.doi.org/10.1016/j.urology.2025.12.035</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_37dd61cdc4c0b0739ecb314828c957d7 |
| identifier_str_mv | 10.1016/j.urology.2025.12.035 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/31017820 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Tranexamic acid for the management of hematuria: A systematic reviewLina Naseralallah (14146465)Dima Nasrallah (22225495)Raneem Alsheikh (20644332)Deemah Assami (22225492)Rawan Boudaka (22963528)Biomedical and clinical sciencesClinical sciencesPharmacology and pharmaceutical sciencesTranexamic acid (TXA)HematuriaUrologyAntifibrinolytic agentsPostoperative bleeding<h3 dir="ltr">Objective</h3><p dir="ltr">To evaluate TXA’s efficacy in managing hematuria and synthesize current evidence to guide urological practice. </p><h3 dir="ltr">Methods</h3><p dir="ltr">This systematic review followed PRISMA 2020 guidelines and was registered in PROSPERO (CRD42022335404). We searched four databases, including PubMed, EMBASE, CINAHL, and Cochrane, for studies on TXA use in adults with hematuria with either interventional or observational designs. Data extraction and quality assessment were performed independently by two reviewers, and findings were summarized using a narrative synthesis. </p><h3 dir="ltr">Results</h3><p dir="ltr">The search yielded 227 records, of which seven studies (970 participants) met inclusion criteria. Four trials on postoperative hematuria showed that tranexamic acid (TXA)—particularly intravenous—consistently reduced hemoglobin decline and blood loss. Three studies on non-postoperative hematuria demonstrated reductions in visible hematuria and symptom duration, though effects on transfusion and laboratory outcomes were variable. All administration routes—intravenous, oral, and intravesical irrigation—were effective; however, IV TXA showed superior outcomes in postoperative cases, while oral and irrigation routes appeared more advantageous in non-surgical settings. </p><h3 dir="ltr">Conclusion</h3><p dir="ltr">TXA is effective in reducing both postoperative and non-postoperative hematuria, supporting its expanded use in urological practice. However, larger, high-quality studies are needed to confirm these findings and refine treatment protocols.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Urology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.urology.2025.12.035" target="_blank">https://dx.doi.org/10.1016/j.urology.2025.12.035</a></p>2025-12-26T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.urology.2025.12.035https://figshare.com/articles/journal_contribution/Tranexamic_acid_for_the_management_of_hematuria_A_systematic_review/31017820CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/310178202025-12-26T09:00:00Z |
| spellingShingle | Tranexamic acid for the management of hematuria: A systematic review Lina Naseralallah (14146465) Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Tranexamic acid (TXA) Hematuria Urology Antifibrinolytic agents Postoperative bleeding |
| status_str | publishedVersion |
| title | Tranexamic acid for the management of hematuria: A systematic review |
| title_full | Tranexamic acid for the management of hematuria: A systematic review |
| title_fullStr | Tranexamic acid for the management of hematuria: A systematic review |
| title_full_unstemmed | Tranexamic acid for the management of hematuria: A systematic review |
| title_short | Tranexamic acid for the management of hematuria: A systematic review |
| title_sort | Tranexamic acid for the management of hematuria: A systematic review |
| topic | Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Tranexamic acid (TXA) Hematuria Urology Antifibrinolytic agents Postoperative bleeding |