TERT Gene Fusions Characterize a Subset of Metastatic Leydig Cell Tumors

TERT Gene Fusions Characterize a Subset of Metastatic Leydig Cell Tumors

<h3>Objective</h3><p dir="ltr">Metastatic Leydig cell tumors (LCT) are rare, difficult-to-treat malignancies without known underlying molecular–genetic events. An index case of metastatic LCT showed an <i>LDLR–TERT</i> gene fusion upon routine genetic profilin...

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Main Author: Bozo Kruslin (10418791) (author)
Other Authors: Zoran Gatalica (3353003) (author), Ondrej Hes (5980643) (author), Faruk Skenderi (6616190) (author), Markku Miettinen (415251) (author), Elma Contreras (16561296) (author), Joanne Xiu (5024744) (author), Michelle Ellis (16928736) (author), Elena Florento (16928739) (author), Semir Vranic (3353012) (author), Jeffrey Swensen (4760673) (author)
Published: 2021
Subjects:
Biological sciences
Genetics
Biomedical and clinical sciences
Clinical sciences
Oncology and carcinogenesis
Sex cord–stromal tumors
Molecular profiling
Sequencing
Targeted therapy
Leydig cell tumors
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