Efficient degradation of chloroquine drug by electro-Fenton oxidation: Effects of operating conditions and degradation mechanism
<p dir="ltr">In this work, the degradation of chloroquine (CLQ), an antiviral and antimalarial drug, using electro-Fenton oxidation was investigated. Due to the importance of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) generation during electro-Fenton oxida...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| منشور في: |
2020
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513555014877184 |
|---|---|
| author | Sondos Midassi (17115616) |
| author2 | Ahmed Bedoui (16488921) Nasr Bensalah (14778253) |
| author2_role | author author |
| author_facet | Sondos Midassi (17115616) Ahmed Bedoui (16488921) Nasr Bensalah (14778253) |
| author_role | author |
| dc.creator.none.fl_str_mv | Sondos Midassi (17115616) Ahmed Bedoui (16488921) Nasr Bensalah (14778253) |
| dc.date.none.fl_str_mv | 2020-12-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.chemosphere.2020.127558 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Efficient_degradation_of_chloroquine_drug_by_electro-Fenton_oxidation_Effects_of_operating_conditions_and_degradation_mechanism/24270325 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Chemical sciences Medicinal and biomolecular chemistry Engineering Chemical engineering Chloroquine Electro-fenton H2O2 generation Boron-doped diamond Hydroxyl radicals |
| dc.title.none.fl_str_mv | Efficient degradation of chloroquine drug by electro-Fenton oxidation: Effects of operating conditions and degradation mechanism |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">In this work, the degradation of chloroquine (CLQ), an antiviral and antimalarial drug, using electro-Fenton oxidation was investigated. Due to the importance of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) generation during electro-Fenton oxidation, effects of pH, current density, molecular oxygen (O<sub>2</sub>) flow rate, and anode material on H<sub>2</sub>O<sub>2</sub> generation were evaluated. H<sub>2</sub>O<sub>2</sub> generation was enhanced by increasing the current density up to 60 mA/cm<sup>2</sup> and the O<sub>2</sub> flow rate up to 80 mL/min at pH 3.0 and using carbon felt cathode and boron-doped diamond (BDD) anode. Electro-Fenton-BDD oxidation achieved the total CLQ depletion and 92% total organic carbon (TOC) removal. Electro-Fenton-BDD oxidation was more effective than electro-Fenton-Pt and anodic oxidation using Pt and BDD anodes. The efficiency of CLQ depletion by electro-Fenton-BDD oxidation raises by increasing the current density and Fe<sup>2+</sup> dose; however it drops with the increase of pH and CLQ concentration. CLQ depletion follows a pseudo-first order kinetics in all the experiments. The identification of CLQ degradation intermediates by chromatography methods confirms the formation of 7-chloro-4-quinolinamine, oxamic, and oxalic acids. Quantitative amounts of chlorides, nitrates, and ammonium ions are released during electro-Fenton oxidation of CLQ. The high efficiency of electro-Fenton oxidation derives from the generation of hydroxyl radicals from the catalytic decomposition of H<sub>2</sub>O<sub>2</sub> by Fe<sup>2+</sup> in solution, and the electrogeneration of hydroxyl and sulfates radicals and other strong oxidants (persulfates) from the oxidation of the electrolyte at the surface BDD anode. Electro-Fenton oxidation has the potential to be an alternative method for treating wastewaters contaminated with CLQ and its derivatives.</p><h2>Other Information</h2><p dir="ltr">Published in: Chemosphere<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.chemosphere.2020.127558" target="_blank">https://dx.doi.org/10.1016/j.chemosphere.2020.127558</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_3a4eacb27462e774ba0d2d480f3e93d5 |
| identifier_str_mv | 10.1016/j.chemosphere.2020.127558 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24270325 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Efficient degradation of chloroquine drug by electro-Fenton oxidation: Effects of operating conditions and degradation mechanismSondos Midassi (17115616)Ahmed Bedoui (16488921)Nasr Bensalah (14778253)Chemical sciencesMedicinal and biomolecular chemistryEngineeringChemical engineeringChloroquineElectro-fentonH2O2 generationBoron-doped diamondHydroxyl radicals<p dir="ltr">In this work, the degradation of chloroquine (CLQ), an antiviral and antimalarial drug, using electro-Fenton oxidation was investigated. Due to the importance of hydrogen peroxide (H<sub>2</sub>O<sub>2</sub>) generation during electro-Fenton oxidation, effects of pH, current density, molecular oxygen (O<sub>2</sub>) flow rate, and anode material on H<sub>2</sub>O<sub>2</sub> generation were evaluated. H<sub>2</sub>O<sub>2</sub> generation was enhanced by increasing the current density up to 60 mA/cm<sup>2</sup> and the O<sub>2</sub> flow rate up to 80 mL/min at pH 3.0 and using carbon felt cathode and boron-doped diamond (BDD) anode. Electro-Fenton-BDD oxidation achieved the total CLQ depletion and 92% total organic carbon (TOC) removal. Electro-Fenton-BDD oxidation was more effective than electro-Fenton-Pt and anodic oxidation using Pt and BDD anodes. The efficiency of CLQ depletion by electro-Fenton-BDD oxidation raises by increasing the current density and Fe<sup>2+</sup> dose; however it drops with the increase of pH and CLQ concentration. CLQ depletion follows a pseudo-first order kinetics in all the experiments. The identification of CLQ degradation intermediates by chromatography methods confirms the formation of 7-chloro-4-quinolinamine, oxamic, and oxalic acids. Quantitative amounts of chlorides, nitrates, and ammonium ions are released during electro-Fenton oxidation of CLQ. The high efficiency of electro-Fenton oxidation derives from the generation of hydroxyl radicals from the catalytic decomposition of H<sub>2</sub>O<sub>2</sub> by Fe<sup>2+</sup> in solution, and the electrogeneration of hydroxyl and sulfates radicals and other strong oxidants (persulfates) from the oxidation of the electrolyte at the surface BDD anode. Electro-Fenton oxidation has the potential to be an alternative method for treating wastewaters contaminated with CLQ and its derivatives.</p><h2>Other Information</h2><p dir="ltr">Published in: Chemosphere<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.chemosphere.2020.127558" target="_blank">https://dx.doi.org/10.1016/j.chemosphere.2020.127558</a></p>2020-12-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.chemosphere.2020.127558https://figshare.com/articles/journal_contribution/Efficient_degradation_of_chloroquine_drug_by_electro-Fenton_oxidation_Effects_of_operating_conditions_and_degradation_mechanism/24270325CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/242703252020-12-01T00:00:00Z |
| spellingShingle | Efficient degradation of chloroquine drug by electro-Fenton oxidation: Effects of operating conditions and degradation mechanism Sondos Midassi (17115616) Chemical sciences Medicinal and biomolecular chemistry Engineering Chemical engineering Chloroquine Electro-fenton H2O2 generation Boron-doped diamond Hydroxyl radicals |
| status_str | publishedVersion |
| title | Efficient degradation of chloroquine drug by electro-Fenton oxidation: Effects of operating conditions and degradation mechanism |
| title_full | Efficient degradation of chloroquine drug by electro-Fenton oxidation: Effects of operating conditions and degradation mechanism |
| title_fullStr | Efficient degradation of chloroquine drug by electro-Fenton oxidation: Effects of operating conditions and degradation mechanism |
| title_full_unstemmed | Efficient degradation of chloroquine drug by electro-Fenton oxidation: Effects of operating conditions and degradation mechanism |
| title_short | Efficient degradation of chloroquine drug by electro-Fenton oxidation: Effects of operating conditions and degradation mechanism |
| title_sort | Efficient degradation of chloroquine drug by electro-Fenton oxidation: Effects of operating conditions and degradation mechanism |
| topic | Chemical sciences Medicinal and biomolecular chemistry Engineering Chemical engineering Chloroquine Electro-fenton H2O2 generation Boron-doped diamond Hydroxyl radicals |