Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

Genetic architecture of spatial electrical biomarkers for cardiac arrhythmia and relationship with cardiovascular disease

<p dir="ltr">The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 6...

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محفوظ في:
التفاصيل البيبلوغرافية
المؤلف الرئيسي: William J. Young (18426897) (author)
مؤلفون آخرون: Jeffrey Haessler (169224) (author), Jan-Walter Benjamins (18426906) (author), Linda Repetto (11285123) (author), Jie Yao (1440151) (author), Aaron Isaacs (174648) (author), Andrew R. Harper (11548995) (author), Julia Ramirez (2614513) (author), Sophie Garnier (278324) (author), Stefan van Duijvenboden (7116386) (author), Antoine R. Baldassari (8578587) (author), Maria Pina Concas (12643515) (author), ThuyVy Duong (18426903) (author), Luisa Foco (43249) (author), Jonas L. Isaksen (4433593) (author), Hao Mei (73778) (author), Raymond Noordam (333224) (author), Casia Nursyifa (18426912) (author), Anne Richmond (5854361) (author), Meddly L. Santolalla (9733729) (author), Colleen M. Sitlani (8578590) (author), Negin Soroush (10489739) (author), Sébastien Thériault (11965445) (author), Stella Trompet (174901) (author), Stefanie Aeschbacher (3164868) (author), Fariba Ahmadizar (791472) (author), Alvaro Alonso (211735) (author), Jennifer A. Brody (7743146) (author), Archie Campbell (669891) (author), Adolfo Correa (610800) (author), Dawood Darbar (181657) (author), Antonio De Luca (9038661) (author), Jean-François Deleuze (3626111) (author), Christina Ellervik (3823540) (author), Christian Fuchsberger (76512) (author), Anuj Goel (258576) (author), Christopher Grace (834640) (author), Xiuqing Guo (73591) (author), Torben Hansen (140523) (author), Susan R. Heckbert (7634165) (author), Rebecca D. Jackson (7802564) (author), Jan A. Kors (7464284) (author), Maria Fernanda Lima-Costa (7232726) (author), Allan Linneberg (139773) (author), Peter W. Macfarlane (7473807) (author), Alanna C. Morrison (7634126) (author), Pau Navarro (160568) (author), David J. Porteous (107720) (author), Peter P. Pramstaller (7656497) (author), Alexander P. Reiner (8174154) (author), Lorenz Risch (430248) (author), Ulrich Schotten (5564384) (author), Xia Shen (145341) (author), Gianfranco Sinagra (290352) (author), Elsayed Z. Soliman (7743179) (author), Monika Stoll (77524) (author), Eduardo Tarazona-Santos (145092) (author), Andrew Tinker (477693) (author), Katerina Trajanoska (754245) (author), Eric Villard (239186) (author), Helen R. Warren (5410760) (author), Eric A. Whitsel (7370528) (author), Kerri L. Wiggins (8174145) (author), Dan E. Arking (7588586) (author), Christy L. Avery (8207355) (author), David Conen (191914) (author), Giorgia Girotto (149894) (author), Niels Grarup (154019) (author), Caroline Hayward (149856) (author), J.Wouter Jukema (19483594) (author), Dennis O. Mook-Kanamori (148319) (author), Morten Salling Olesen (10272920) (author), Sandosh Padmanabhan (238533) (author), Bruce M. Psaty (7634144) (author), Cristian Pattaro (65825) (author), Antonio Luiz P. Ribeiro (4033124) (author), Jerome I. Rotter (7634114) (author), Bruno H. Stricker (7464293) (author), Pim van der Harst (65060) (author), Cornelia M. van Duijn (7692962) (author), Niek Verweij (128858) (author), James G. Wilson (7218929) (author), Michele Orini (3097818) (author), Philippe Charron (239184) (author), Hugh Watkins (62729) (author), Charles Kooperberg (18693) (author), Henry J. Lin (6894089) (author), James F. Wilson (7638917) (author), Jørgen K. Kanters (7743167) (author), Nona Sotoodehnia (143373) (author), Borbala Mifsud (3907267) (author), Pier D. Lambiase (10163594) (author), Larisa G. Tereshchenko (8762748) (author), Patricia B. Munroe (7588601) (author)
منشور في: 2023
الموضوعات:
Biological sciences
Genetics
Biomedical and clinical sciences
Cardiovascular medicine and haematology
Health sciences
Epidemiology
QRS-T Angles
Vectorcardiogram
Genome-Wide Association Studies
Cardiac and Vascular Development
Electrocardiographic Traits
Arrhythmia
Genetic Loci
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الوصف
الملخص:<p dir="ltr">The 3-dimensional spatial and 2-dimensional frontal QRS-T angles are measures derived from the vectorcardiogram. They are independent risk predictors for arrhythmia, but the underlying biology is unknown. Using multi-ancestry genome-wide association studies we identify 61 (58 previously unreported) loci for the spatial QRS-T angle (<i>N</i> = 118,780) and 11 for the frontal QRS-T angle (<i>N</i> = 159,715). Seven out of the 61 spatial QRS-T angle loci have not been reported for other electrocardiographic measures. Enrichments are observed in pathways related to cardiac and vascular development, muscle contraction, and hypertrophy. Pairwise genome-wide association studies with classical ECG traits identify shared genetic influences with PR interval and QRS duration. Phenome-wide scanning indicate associations with atrial fibrillation, atrioventricular block and arterial embolism and genetically determined QRS-T angle measures are associated with fascicular and bundle branch block (and also atrioventricular block for the frontal QRS-T angle). We identify potential biology involved in the QRS-T angle and their genetic relationships with cardiovascular traits and diseases, may inform future research and risk prediction.</p><h2>Other Information</h2><p dir="ltr">Published in: Nature Communications<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41467-023-36997-w" target="_blank">https://dx.doi.org/10.1038/s41467-023-36997-w</a></p>

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