Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer’s disease
<p dir="ltr">Several studies reported an association between CSF alpha-synuclein (α-syn) and tau in Alzheimer’s disease (AD), and demonstrated the significance of α-syn in improving the diagnostic sensitivity/specificity of classical AD CSF biomarkers. In the current study, we measur...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | , , , , , , , |
| Published: |
2017
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864513556578304000 |
|---|---|
| author | Nour K. Majbour (8809316) |
| author2 | Davide Chiasserini (432117) Nishant N. Vaikath (2901785) Paolo Eusebi (432118) Takahiko Tokuda (105837) Wilma van de Berg (3554690) Lucilla Parnetti (120805) Paolo Calabresi (24897) Omar M. A. El-Agnaf (8809331) |
| author2_role | author author author author author author author author |
| author_facet | Nour K. Majbour (8809316) Davide Chiasserini (432117) Nishant N. Vaikath (2901785) Paolo Eusebi (432118) Takahiko Tokuda (105837) Wilma van de Berg (3554690) Lucilla Parnetti (120805) Paolo Calabresi (24897) Omar M. A. El-Agnaf (8809331) |
| author_role | author |
| dc.creator.none.fl_str_mv | Nour K. Majbour (8809316) Davide Chiasserini (432117) Nishant N. Vaikath (2901785) Paolo Eusebi (432118) Takahiko Tokuda (105837) Wilma van de Berg (3554690) Lucilla Parnetti (120805) Paolo Calabresi (24897) Omar M. A. El-Agnaf (8809331) |
| dc.date.none.fl_str_mv | 2017-01-10T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1038/srep40263 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Increased_levels_of_CSF_total_but_not_oligomeric_or_phosphorylated_forms_of_alpha-synuclein_in_patients_diagnosed_with_probable_Alzheimer_s_disease/27088027 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Neurosciences Alpha-synuclein (α-syn) Alzheimer’s disease (AD) Cerebrospinal fluid (CSF) Biomarkers Tau protein Oligomers |
| dc.title.none.fl_str_mv | Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer’s disease |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Several studies reported an association between CSF alpha-synuclein (α-syn) and tau in Alzheimer’s disease (AD), and demonstrated the significance of α-syn in improving the diagnostic sensitivity/specificity of classical AD CSF biomarkers. In the current study, we measured CSF levels of different α-syn species in a cohort of AD patients (n = 225) who showed a CSF profile typical of AD at baseline as well as in cognitively intact controls (n = 68). CSF total α-syn (t-α-syn) significantly increased in the AD group (p < 0.0001) compared to controls, while oligomeric- and phosphorylated-Ser129-α-syn did not change significantly. ROC analysis showed a sensitivity of 85% and a specificity of 84% (AUC = 0.88) in distinguishing AD from controls. T-α-syn levels correlated positively with tau species in AD group and negatively with baseline MMSE score. Our data support the added value of measurement of CSF α-syn species for further characterization of the CSF AD profile.</p><h2>Other Information</h2><p dir="ltr">Published in: Scientific Reports<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/srep40263" target="_blank">https://dx.doi.org/10.1038/srep40263</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_3ae8567e9b13c4fb91d12264dcd1b35b |
| identifier_str_mv | 10.1038/srep40263 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/27088027 |
| publishDate | 2017 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer’s diseaseNour K. Majbour (8809316)Davide Chiasserini (432117)Nishant N. Vaikath (2901785)Paolo Eusebi (432118)Takahiko Tokuda (105837)Wilma van de Berg (3554690)Lucilla Parnetti (120805)Paolo Calabresi (24897)Omar M. A. El-Agnaf (8809331)Biomedical and clinical sciencesNeurosciencesAlpha-synuclein (α-syn)Alzheimer’s disease (AD)Cerebrospinal fluid (CSF)BiomarkersTau proteinOligomers<p dir="ltr">Several studies reported an association between CSF alpha-synuclein (α-syn) and tau in Alzheimer’s disease (AD), and demonstrated the significance of α-syn in improving the diagnostic sensitivity/specificity of classical AD CSF biomarkers. In the current study, we measured CSF levels of different α-syn species in a cohort of AD patients (n = 225) who showed a CSF profile typical of AD at baseline as well as in cognitively intact controls (n = 68). CSF total α-syn (t-α-syn) significantly increased in the AD group (p < 0.0001) compared to controls, while oligomeric- and phosphorylated-Ser129-α-syn did not change significantly. ROC analysis showed a sensitivity of 85% and a specificity of 84% (AUC = 0.88) in distinguishing AD from controls. T-α-syn levels correlated positively with tau species in AD group and negatively with baseline MMSE score. Our data support the added value of measurement of CSF α-syn species for further characterization of the CSF AD profile.</p><h2>Other Information</h2><p dir="ltr">Published in: Scientific Reports<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/srep40263" target="_blank">https://dx.doi.org/10.1038/srep40263</a></p>2017-01-10T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1038/srep40263https://figshare.com/articles/journal_contribution/Increased_levels_of_CSF_total_but_not_oligomeric_or_phosphorylated_forms_of_alpha-synuclein_in_patients_diagnosed_with_probable_Alzheimer_s_disease/27088027CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/270880272017-01-10T03:00:00Z |
| spellingShingle | Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer’s disease Nour K. Majbour (8809316) Biomedical and clinical sciences Neurosciences Alpha-synuclein (α-syn) Alzheimer’s disease (AD) Cerebrospinal fluid (CSF) Biomarkers Tau protein Oligomers |
| status_str | publishedVersion |
| title | Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer’s disease |
| title_full | Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer’s disease |
| title_fullStr | Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer’s disease |
| title_full_unstemmed | Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer’s disease |
| title_short | Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer’s disease |
| title_sort | Increased levels of CSF total but not oligomeric or phosphorylated forms of alpha-synuclein in patients diagnosed with probable Alzheimer’s disease |
| topic | Biomedical and clinical sciences Neurosciences Alpha-synuclein (α-syn) Alzheimer’s disease (AD) Cerebrospinal fluid (CSF) Biomarkers Tau protein Oligomers |