Hepatitis B Virus Molecular Epidemiology, Host-Virus Interaction, Coinfection, and Laboratory Diagnosis in the MENA Region: An Update
<div><p>Hepatitis B virus (HBV) is an enveloped partial double-stranded DNA virus that can cause acute and chronic hepatitis. According to the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC), 257 million people are living with HBV. Moreover, 20,90...
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| _version_ | 1864513524013727744 |
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| author | Duaa W. Al-Sadeq (10976754) |
| author2 | Sara A. Taleb (4675861) Roan E. Zaied (16868604) Sara M. Fahad (18112279) Maria K. Smatti (4675852) Balsam R. Rizeq (18095371) Asmaa A. Al Thani (10494576) Hadi M. Yassine (4675846) Gheyath K. Nasrallah (9200525) |
| author2_role | author author author author author author author author |
| author_facet | Duaa W. Al-Sadeq (10976754) Sara A. Taleb (4675861) Roan E. Zaied (16868604) Sara M. Fahad (18112279) Maria K. Smatti (4675852) Balsam R. Rizeq (18095371) Asmaa A. Al Thani (10494576) Hadi M. Yassine (4675846) Gheyath K. Nasrallah (9200525) |
| author_role | author |
| dc.creator.none.fl_str_mv | Duaa W. Al-Sadeq (10976754) Sara A. Taleb (4675861) Roan E. Zaied (16868604) Sara M. Fahad (18112279) Maria K. Smatti (4675852) Balsam R. Rizeq (18095371) Asmaa A. Al Thani (10494576) Hadi M. Yassine (4675846) Gheyath K. Nasrallah (9200525) |
| dc.date.none.fl_str_mv | 2019-05-11T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/pathogens8020063 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Hepatitis_B_Virus_Molecular_Epidemiology_Host-Virus_Interaction_Coinfection_and_Laboratory_Diagnosis_in_the_MENA_Region_An_Update/25347823 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Immunology HBV seroprevalence genotypes pathogenesis transfusion viremia |
| dc.title.none.fl_str_mv | Hepatitis B Virus Molecular Epidemiology, Host-Virus Interaction, Coinfection, and Laboratory Diagnosis in the MENA Region: An Update |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Hepatitis B virus (HBV) is an enveloped partial double-stranded DNA virus that can cause acute and chronic hepatitis. According to the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC), 257 million people are living with HBV. Moreover, 20,900 acute hepatitis B cases were reported in 2016. Hepatitis B is highly prevalent in the African, Western Pacific, Eastern Mediterranean, South-East Asia, and European regions, respectively. Due to the high mutational rate of HBV and lack of reverse transcriptase proofreading activity, ten different genotypes with different geographical distributions have been identified. HBV pathogenesis and severity of infection depend on several host and viral factors, particularly, the genetic variability of both the host and virus. Although HBV infection is a global health concern, there is a lack of adequate studies and reports in the Middle East and North Africa (MENA) region. Here, we provide a review on HBV epidemiology, pathogenesis, host–pathogen interactions, coinfection with selected viruses, and laboratory diagnosis, focusing on studies conducted in the MENA region to determine the current situation of the HBV infection and outline the future study areas.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Pathogens<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/pathogens8020063" target="_blank">https://dx.doi.org/10.3390/pathogens8020063</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_3b432a5a624673c770c531e960e7626c |
| identifier_str_mv | 10.3390/pathogens8020063 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25347823 |
| publishDate | 2019 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Hepatitis B Virus Molecular Epidemiology, Host-Virus Interaction, Coinfection, and Laboratory Diagnosis in the MENA Region: An UpdateDuaa W. Al-Sadeq (10976754)Sara A. Taleb (4675861)Roan E. Zaied (16868604)Sara M. Fahad (18112279)Maria K. Smatti (4675852)Balsam R. Rizeq (18095371)Asmaa A. Al Thani (10494576)Hadi M. Yassine (4675846)Gheyath K. Nasrallah (9200525)Biomedical and clinical sciencesClinical sciencesImmunologyHBVseroprevalencegenotypespathogenesistransfusionviremia<div><p>Hepatitis B virus (HBV) is an enveloped partial double-stranded DNA virus that can cause acute and chronic hepatitis. According to the World Health Organization (WHO) and the Centers for Disease Control and Prevention (CDC), 257 million people are living with HBV. Moreover, 20,900 acute hepatitis B cases were reported in 2016. Hepatitis B is highly prevalent in the African, Western Pacific, Eastern Mediterranean, South-East Asia, and European regions, respectively. Due to the high mutational rate of HBV and lack of reverse transcriptase proofreading activity, ten different genotypes with different geographical distributions have been identified. HBV pathogenesis and severity of infection depend on several host and viral factors, particularly, the genetic variability of both the host and virus. Although HBV infection is a global health concern, there is a lack of adequate studies and reports in the Middle East and North Africa (MENA) region. Here, we provide a review on HBV epidemiology, pathogenesis, host–pathogen interactions, coinfection with selected viruses, and laboratory diagnosis, focusing on studies conducted in the MENA region to determine the current situation of the HBV infection and outline the future study areas.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Pathogens<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/pathogens8020063" target="_blank">https://dx.doi.org/10.3390/pathogens8020063</a></p>2019-05-11T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/pathogens8020063https://figshare.com/articles/journal_contribution/Hepatitis_B_Virus_Molecular_Epidemiology_Host-Virus_Interaction_Coinfection_and_Laboratory_Diagnosis_in_the_MENA_Region_An_Update/25347823CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/253478232019-05-11T03:00:00Z |
| spellingShingle | Hepatitis B Virus Molecular Epidemiology, Host-Virus Interaction, Coinfection, and Laboratory Diagnosis in the MENA Region: An Update Duaa W. Al-Sadeq (10976754) Biomedical and clinical sciences Clinical sciences Immunology HBV seroprevalence genotypes pathogenesis transfusion viremia |
| status_str | publishedVersion |
| title | Hepatitis B Virus Molecular Epidemiology, Host-Virus Interaction, Coinfection, and Laboratory Diagnosis in the MENA Region: An Update |
| title_full | Hepatitis B Virus Molecular Epidemiology, Host-Virus Interaction, Coinfection, and Laboratory Diagnosis in the MENA Region: An Update |
| title_fullStr | Hepatitis B Virus Molecular Epidemiology, Host-Virus Interaction, Coinfection, and Laboratory Diagnosis in the MENA Region: An Update |
| title_full_unstemmed | Hepatitis B Virus Molecular Epidemiology, Host-Virus Interaction, Coinfection, and Laboratory Diagnosis in the MENA Region: An Update |
| title_short | Hepatitis B Virus Molecular Epidemiology, Host-Virus Interaction, Coinfection, and Laboratory Diagnosis in the MENA Region: An Update |
| title_sort | Hepatitis B Virus Molecular Epidemiology, Host-Virus Interaction, Coinfection, and Laboratory Diagnosis in the MENA Region: An Update |
| topic | Biomedical and clinical sciences Clinical sciences Immunology HBV seroprevalence genotypes pathogenesis transfusion viremia |