Glucose excursions in type 2 diabetes modulate amyloid-related proteins associated with dementia
<p dir="ltr">We have reported that hypoglycemia was associated with changes in Alzheimer’s disease (AD)-related proteins in accord with the direct link of cognitive dysfunction to hypoglycemia. Dementia is a recognized complication of type 2 diabetes (T2D) with an increasing prevalen...
محفوظ في:
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| مؤلفون آخرون: | , , , |
| منشور في: |
2021
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513516783796224 |
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| author | Abu Saleh Md Moin (6189512) |
| author2 | Ahmed Al-Qaissi (9975173) Thozhukat Sathyapalan (704787) Stephen L. Atkin (6684368) Alexandra E. Butler (6189536) |
| author2_role | author author author author |
| author_facet | Abu Saleh Md Moin (6189512) Ahmed Al-Qaissi (9975173) Thozhukat Sathyapalan (704787) Stephen L. Atkin (6684368) Alexandra E. Butler (6189536) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abu Saleh Md Moin (6189512) Ahmed Al-Qaissi (9975173) Thozhukat Sathyapalan (704787) Stephen L. Atkin (6684368) Alexandra E. Butler (6189536) |
| dc.date.none.fl_str_mv | 2021-03-31T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s12967-021-02797-3 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Glucose_excursions_in_type_2_diabetes_modulate_amyloid-related_proteins_associated_with_dementia/25756446 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Type 2 diabetes Glucose variability Amyloid-associated proteins Alzheimer’s disease |
| dc.title.none.fl_str_mv | Glucose excursions in type 2 diabetes modulate amyloid-related proteins associated with dementia |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">We have reported that hypoglycemia was associated with changes in Alzheimer’s disease (AD)-related proteins in accord with the direct link of cognitive dysfunction to hypoglycemia. Dementia is a recognized complication of type 2 diabetes (T2D) with an increasing prevalence, and AD is the most common cause. However, whilst the stress induced by hypoglycemia was likely the trigger, the contribution of the fall in glucose alone was unclear, given that glucose variability is associated with lower level cognitive function.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Translational Medicine<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12967-021-02797-3" target="_blank">https://dx.doi.org/10.1186/s12967-021-02797-3</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_3bf6951a3c0c65c8c75f3fcbcea1155a |
| identifier_str_mv | 10.1186/s12967-021-02797-3 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25756446 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Glucose excursions in type 2 diabetes modulate amyloid-related proteins associated with dementiaAbu Saleh Md Moin (6189512)Ahmed Al-Qaissi (9975173)Thozhukat Sathyapalan (704787)Stephen L. Atkin (6684368)Alexandra E. Butler (6189536)Biomedical and clinical sciencesClinical sciencesType 2 diabetesGlucose variabilityAmyloid-associated proteinsAlzheimer’s disease<p dir="ltr">We have reported that hypoglycemia was associated with changes in Alzheimer’s disease (AD)-related proteins in accord with the direct link of cognitive dysfunction to hypoglycemia. Dementia is a recognized complication of type 2 diabetes (T2D) with an increasing prevalence, and AD is the most common cause. However, whilst the stress induced by hypoglycemia was likely the trigger, the contribution of the fall in glucose alone was unclear, given that glucose variability is associated with lower level cognitive function.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Translational Medicine<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s12967-021-02797-3" target="_blank">https://dx.doi.org/10.1186/s12967-021-02797-3</a></p>2021-03-31T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s12967-021-02797-3https://figshare.com/articles/journal_contribution/Glucose_excursions_in_type_2_diabetes_modulate_amyloid-related_proteins_associated_with_dementia/25756446CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/257564462021-03-31T03:00:00Z |
| spellingShingle | Glucose excursions in type 2 diabetes modulate amyloid-related proteins associated with dementia Abu Saleh Md Moin (6189512) Biomedical and clinical sciences Clinical sciences Type 2 diabetes Glucose variability Amyloid-associated proteins Alzheimer’s disease |
| status_str | publishedVersion |
| title | Glucose excursions in type 2 diabetes modulate amyloid-related proteins associated with dementia |
| title_full | Glucose excursions in type 2 diabetes modulate amyloid-related proteins associated with dementia |
| title_fullStr | Glucose excursions in type 2 diabetes modulate amyloid-related proteins associated with dementia |
| title_full_unstemmed | Glucose excursions in type 2 diabetes modulate amyloid-related proteins associated with dementia |
| title_short | Glucose excursions in type 2 diabetes modulate amyloid-related proteins associated with dementia |
| title_sort | Glucose excursions in type 2 diabetes modulate amyloid-related proteins associated with dementia |
| topic | Biomedical and clinical sciences Clinical sciences Type 2 diabetes Glucose variability Amyloid-associated proteins Alzheimer’s disease |