A cross-sectional analysis of zinc and copper levels and their relationship to cardiovascular disease risk markers in Qatar biobank participants
<p dir="ltr">Cardiovascular diseases (CVD) are the leading cause of mortality and morbidity worldwide. Dietary intake, particularly zinc (Zn) and copper (Cu) has been strongly associated with CVD. These trace elements play a crucial role in human enzyme activity, suppressing inflamma...
محفوظ في:
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| مؤلفون آخرون: | , , , , |
| منشور في: |
2024
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513537468006400 |
|---|---|
| author | Abdelhamid Kerkadi (10724304) |
| author2 | Hicham Raiq (21160457) Mohammad Prince (21187979) Loulia Bader (14151585) Abderrezzaq Soltani (19532617) Abdelali Agouni (21241658) |
| author2_role | author author author author author |
| author_facet | Abdelhamid Kerkadi (10724304) Hicham Raiq (21160457) Mohammad Prince (21187979) Loulia Bader (14151585) Abderrezzaq Soltani (19532617) Abdelali Agouni (21241658) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abdelhamid Kerkadi (10724304) Hicham Raiq (21160457) Mohammad Prince (21187979) Loulia Bader (14151585) Abderrezzaq Soltani (19532617) Abdelali Agouni (21241658) |
| dc.date.none.fl_str_mv | 2024-01-05T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fcvm.2023.1305588 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/A_cross-sectional_analysis_of_zinc_and_copper_levels_and_their_relationship_to_cardiovascular_disease_risk_markers_in_Qatar_biobank_participants/30227551 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Medical biochemistry and metabolomics Health sciences Epidemiology Public health Zinc Copper Zinc/Copper ratio Cardiovascular disease risk Trace elements |
| dc.title.none.fl_str_mv | A cross-sectional analysis of zinc and copper levels and their relationship to cardiovascular disease risk markers in Qatar biobank participants |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Cardiovascular diseases (CVD) are the leading cause of mortality and morbidity worldwide. Dietary intake, particularly zinc (Zn) and copper (Cu) has been strongly associated with CVD. These trace elements play a crucial role in human enzyme activity, suppressing inflammation, catalyzing lipid metabolism enzymes, reducing oxidative stress, and regulating glucose metabolism. However, imbalances in these elements are linked to cardiovascular disturbances. Thus, this study aimed to investigate the association between circulating levels of Zn, Cu, and Zn/Cu ratio with CVD risk factors in the Qatari population. Bivariate logistic regression, adjusted for age, nationality, gender, and education was performed to examine the impact of Zn, Cu, and Zn/Cu ratio (as independent variables) on major CVD risk markers (as dependent variables). Participants in the highest Zn tertiles (T2 and T3) were at greater odds ratio (OR) of unfavorable metabolic functions such as elevated HbA1C [OR = 2.5, p = 0.015 (T2) and OR = 3.2, p = 0.002 (T3)], triglycerides [OR = 2.17, p = 0.015 (T2), and TyG index [OR = 2.21, p = 0.004 (T2), and OR = 2.67, p < 0.001 (T3)] compared to T1. Conversely, they had significantly lower ORs for prolonged prothrombin time [OR = 0.37, p = 0.001 (T3)]. Higher levels of Cu (T2 and T3) had higher OR for elevated HDL-C levels [OR = 1.69, p = 0.046 (T2), and OR = 2.27, p = 0.002 (T3)] and lower OR for elevated levels of triglycerides (OR = 0.4, p = 0.009, T3), diastolic blood pressure [OR = 0.41, p = 0.024 (T2), and OR = 0.47, p = 0.049 (T3)], and creatinine kinase (OR = 0.27, p = 0.014, T3) compared to T1. Higher levels of Cu (T2 and T3) were associated with a higher risk for elevated fibrinogen levels [OR = 3.1, p = 0.035 (T2), and OR = 5.04, p = 0.002 (T3)]. Additionally, higher Zn/Cu ratio (T2 and T3) were associated with lower ORs for elevated fibrinogen levels [OR = 0.3, p = 0.005 (T2), and OR = 0.27, p = 0.005 (T3)] compared to T1, indicating a lower risk of developing CVD. The study reveals a link between Zn, Cu, and the Zn/Cu ratio and cardiovascular disease risk. A higher Zn/Cu ratio may protect against CVD, while elevated Cu levels are linked to obesity, fibrinogen levels, and HbA1C. Maintaining optimal levels of these trace elements, either through diet or supplementation, may help reduce CVD risk.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Cardiovascular Medicine<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fcvm.2023.1305588" target="_blank">https://dx.doi.org/10.3389/fcvm.2023.1305588</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_3cd9e1a6af4e8acd6fadd43b8e60bcb6 |
| identifier_str_mv | 10.3389/fcvm.2023.1305588 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30227551 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | A cross-sectional analysis of zinc and copper levels and their relationship to cardiovascular disease risk markers in Qatar biobank participantsAbdelhamid Kerkadi (10724304)Hicham Raiq (21160457)Mohammad Prince (21187979)Loulia Bader (14151585)Abderrezzaq Soltani (19532617)Abdelali Agouni (21241658)Biomedical and clinical sciencesCardiovascular medicine and haematologyMedical biochemistry and metabolomicsHealth sciencesEpidemiologyPublic healthZincCopperZinc/Copper ratioCardiovascular disease riskTrace elements<p dir="ltr">Cardiovascular diseases (CVD) are the leading cause of mortality and morbidity worldwide. Dietary intake, particularly zinc (Zn) and copper (Cu) has been strongly associated with CVD. These trace elements play a crucial role in human enzyme activity, suppressing inflammation, catalyzing lipid metabolism enzymes, reducing oxidative stress, and regulating glucose metabolism. However, imbalances in these elements are linked to cardiovascular disturbances. Thus, this study aimed to investigate the association between circulating levels of Zn, Cu, and Zn/Cu ratio with CVD risk factors in the Qatari population. Bivariate logistic regression, adjusted for age, nationality, gender, and education was performed to examine the impact of Zn, Cu, and Zn/Cu ratio (as independent variables) on major CVD risk markers (as dependent variables). Participants in the highest Zn tertiles (T2 and T3) were at greater odds ratio (OR) of unfavorable metabolic functions such as elevated HbA1C [OR = 2.5, p = 0.015 (T2) and OR = 3.2, p = 0.002 (T3)], triglycerides [OR = 2.17, p = 0.015 (T2), and TyG index [OR = 2.21, p = 0.004 (T2), and OR = 2.67, p < 0.001 (T3)] compared to T1. Conversely, they had significantly lower ORs for prolonged prothrombin time [OR = 0.37, p = 0.001 (T3)]. Higher levels of Cu (T2 and T3) had higher OR for elevated HDL-C levels [OR = 1.69, p = 0.046 (T2), and OR = 2.27, p = 0.002 (T3)] and lower OR for elevated levels of triglycerides (OR = 0.4, p = 0.009, T3), diastolic blood pressure [OR = 0.41, p = 0.024 (T2), and OR = 0.47, p = 0.049 (T3)], and creatinine kinase (OR = 0.27, p = 0.014, T3) compared to T1. Higher levels of Cu (T2 and T3) were associated with a higher risk for elevated fibrinogen levels [OR = 3.1, p = 0.035 (T2), and OR = 5.04, p = 0.002 (T3)]. Additionally, higher Zn/Cu ratio (T2 and T3) were associated with lower ORs for elevated fibrinogen levels [OR = 0.3, p = 0.005 (T2), and OR = 0.27, p = 0.005 (T3)] compared to T1, indicating a lower risk of developing CVD. The study reveals a link between Zn, Cu, and the Zn/Cu ratio and cardiovascular disease risk. A higher Zn/Cu ratio may protect against CVD, while elevated Cu levels are linked to obesity, fibrinogen levels, and HbA1C. Maintaining optimal levels of these trace elements, either through diet or supplementation, may help reduce CVD risk.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Cardiovascular Medicine<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fcvm.2023.1305588" target="_blank">https://dx.doi.org/10.3389/fcvm.2023.1305588</a></p>2024-01-05T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fcvm.2023.1305588https://figshare.com/articles/journal_contribution/A_cross-sectional_analysis_of_zinc_and_copper_levels_and_their_relationship_to_cardiovascular_disease_risk_markers_in_Qatar_biobank_participants/30227551CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/302275512024-01-05T03:00:00Z |
| spellingShingle | A cross-sectional analysis of zinc and copper levels and their relationship to cardiovascular disease risk markers in Qatar biobank participants Abdelhamid Kerkadi (10724304) Biomedical and clinical sciences Cardiovascular medicine and haematology Medical biochemistry and metabolomics Health sciences Epidemiology Public health Zinc Copper Zinc/Copper ratio Cardiovascular disease risk Trace elements |
| status_str | publishedVersion |
| title | A cross-sectional analysis of zinc and copper levels and their relationship to cardiovascular disease risk markers in Qatar biobank participants |
| title_full | A cross-sectional analysis of zinc and copper levels and their relationship to cardiovascular disease risk markers in Qatar biobank participants |
| title_fullStr | A cross-sectional analysis of zinc and copper levels and their relationship to cardiovascular disease risk markers in Qatar biobank participants |
| title_full_unstemmed | A cross-sectional analysis of zinc and copper levels and their relationship to cardiovascular disease risk markers in Qatar biobank participants |
| title_short | A cross-sectional analysis of zinc and copper levels and their relationship to cardiovascular disease risk markers in Qatar biobank participants |
| title_sort | A cross-sectional analysis of zinc and copper levels and their relationship to cardiovascular disease risk markers in Qatar biobank participants |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Medical biochemistry and metabolomics Health sciences Epidemiology Public health Zinc Copper Zinc/Copper ratio Cardiovascular disease risk Trace elements |