Clozapine prescribing practice and trends in Qatar: First national observational study
<h3>Background</h3><p dir="ltr">Clozapine is the gold standard in the management of treatment-resistant schizophrenia. Despite its clinically proven efficacy clozapine utilization is variable globally and published evidence is suggestive of its underutilization. Research...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , , , , |
| منشور في: |
2022
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513566124539904 |
|---|---|
| author | Ovais Wadoo (14777122) |
| author2 | Javed Latoo (14777125) Majid Alabdulla (12051430) Yassin Eltorki (9617390) Sadaf Riaz (6016985) Mustafa Abdul Karim (14152431) Mohammed Abu‐Hafizah (14777128) Shuja Reagu (14568687) |
| author2_role | author author author author author author author |
| author_facet | Ovais Wadoo (14777122) Javed Latoo (14777125) Majid Alabdulla (12051430) Yassin Eltorki (9617390) Sadaf Riaz (6016985) Mustafa Abdul Karim (14152431) Mohammed Abu‐Hafizah (14777128) Shuja Reagu (14568687) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ovais Wadoo (14777122) Javed Latoo (14777125) Majid Alabdulla (12051430) Yassin Eltorki (9617390) Sadaf Riaz (6016985) Mustafa Abdul Karim (14152431) Mohammed Abu‐Hafizah (14777128) Shuja Reagu (14568687) |
| dc.date.none.fl_str_mv | 2022-06-01T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1002/brb3.2617 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Clozapine_prescribing_practice_and_trends_in_Qatar_First_national_observational_study/22257538 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Health sciences Health services and systems Psychology Biological psychology antipsychotic prescribing clozapine mental health services |
| dc.title.none.fl_str_mv | Clozapine prescribing practice and trends in Qatar: First national observational study |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Clozapine is the gold standard in the management of treatment-resistant schizophrenia. Despite its clinically proven efficacy clozapine utilization is variable globally and published evidence is suggestive of its underutilization. Research from the Arab region on clozapine utilization is limited. The aim of our descriptive observational study was to evaluate the prescribing practice of clozapine and its sociodemographic and clinical corelates in the State of Qatar.</p><h3>Methods</h3><p dir="ltr">The study is a retrospective case-note review of all patients maintained on clozapine, in the calendar year 2020. Data were collected on sociodemographic characteristics of the patients; antipsychotic trials before initiating clozapine; and clinical characteristics of the patients, including their diagnoses leading to prescription of clozapine, duration of illness, psychiatric hospitalizations, and co-morbidities.</p><h3>Results</h3><p dir="ltr">During the study period, 100 patients were maintained on clozapine. Patients were mostly Qatari and non-Qatari Arab males. Prescription rates were significantly different for Qatari patients when compared to non-Qatari patients. Most patients had a chronic illness with the age of onset of illness in early adulthood and were diagnosed with schizophrenia or schizoaffective disorder. The mean daily dose of clozapine was 325 mg. Eighty percent of the patients received two or more antipsychotic trials before initiating clozapine. Sixty-eight percent of the patients had more than two antipsychotic trials before initiating Clozapine. One third of patients had no history of psychiatric hospitalizations, and one quarter had five or more previous psychiatric hospitalizations. Of the psychiatric comorbidities, mood and substance use disorders were common. Of medical comorbidities, endocrine and metabolic disorders were common.</p><h3>Conclusion</h3><p dir="ltr">Despite apparent underutilization, the Clozapine prescribing rates in Qatar are comparable to countries with plasma monitoring systems when framed within Qatar's unique demographic context. However, there still is a significant delay in Clozapine initiation despite its clinical superiority.</p><h2>Other Information</h2><p dir="ltr">Published in: Brain and Behavior<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1002/brb3.2617" target="_blank">http://dx.doi.org/10.1002/brb3.2617</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_3d107287e123ae8c16bdb8828e657f16 |
| identifier_str_mv | 10.1002/brb3.2617 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/22257538 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Clozapine prescribing practice and trends in Qatar: First national observational studyOvais Wadoo (14777122)Javed Latoo (14777125)Majid Alabdulla (12051430)Yassin Eltorki (9617390)Sadaf Riaz (6016985)Mustafa Abdul Karim (14152431)Mohammed Abu‐Hafizah (14777128)Shuja Reagu (14568687)Biomedical and clinical sciencesClinical sciencesHealth sciencesHealth services and systemsPsychologyBiological psychologyantipsychotic prescribingclozapinemental health services<h3>Background</h3><p dir="ltr">Clozapine is the gold standard in the management of treatment-resistant schizophrenia. Despite its clinically proven efficacy clozapine utilization is variable globally and published evidence is suggestive of its underutilization. Research from the Arab region on clozapine utilization is limited. The aim of our descriptive observational study was to evaluate the prescribing practice of clozapine and its sociodemographic and clinical corelates in the State of Qatar.</p><h3>Methods</h3><p dir="ltr">The study is a retrospective case-note review of all patients maintained on clozapine, in the calendar year 2020. Data were collected on sociodemographic characteristics of the patients; antipsychotic trials before initiating clozapine; and clinical characteristics of the patients, including their diagnoses leading to prescription of clozapine, duration of illness, psychiatric hospitalizations, and co-morbidities.</p><h3>Results</h3><p dir="ltr">During the study period, 100 patients were maintained on clozapine. Patients were mostly Qatari and non-Qatari Arab males. Prescription rates were significantly different for Qatari patients when compared to non-Qatari patients. Most patients had a chronic illness with the age of onset of illness in early adulthood and were diagnosed with schizophrenia or schizoaffective disorder. The mean daily dose of clozapine was 325 mg. Eighty percent of the patients received two or more antipsychotic trials before initiating clozapine. Sixty-eight percent of the patients had more than two antipsychotic trials before initiating Clozapine. One third of patients had no history of psychiatric hospitalizations, and one quarter had five or more previous psychiatric hospitalizations. Of the psychiatric comorbidities, mood and substance use disorders were common. Of medical comorbidities, endocrine and metabolic disorders were common.</p><h3>Conclusion</h3><p dir="ltr">Despite apparent underutilization, the Clozapine prescribing rates in Qatar are comparable to countries with plasma monitoring systems when framed within Qatar's unique demographic context. However, there still is a significant delay in Clozapine initiation despite its clinical superiority.</p><h2>Other Information</h2><p dir="ltr">Published in: Brain and Behavior<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1002/brb3.2617" target="_blank">http://dx.doi.org/10.1002/brb3.2617</a></p>2022-06-01T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1002/brb3.2617https://figshare.com/articles/journal_contribution/Clozapine_prescribing_practice_and_trends_in_Qatar_First_national_observational_study/22257538CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/222575382022-06-01T06:00:00Z |
| spellingShingle | Clozapine prescribing practice and trends in Qatar: First national observational study Ovais Wadoo (14777122) Biomedical and clinical sciences Clinical sciences Health sciences Health services and systems Psychology Biological psychology antipsychotic prescribing clozapine mental health services |
| status_str | publishedVersion |
| title | Clozapine prescribing practice and trends in Qatar: First national observational study |
| title_full | Clozapine prescribing practice and trends in Qatar: First national observational study |
| title_fullStr | Clozapine prescribing practice and trends in Qatar: First national observational study |
| title_full_unstemmed | Clozapine prescribing practice and trends in Qatar: First national observational study |
| title_short | Clozapine prescribing practice and trends in Qatar: First national observational study |
| title_sort | Clozapine prescribing practice and trends in Qatar: First national observational study |
| topic | Biomedical and clinical sciences Clinical sciences Health sciences Health services and systems Psychology Biological psychology antipsychotic prescribing clozapine mental health services |