Tunisian Artemisia campestris L.: a potential therapeutic agent against myeloma - phytochemical and pharmacological insights
<h3>Background</h3><p dir="ltr">Artemisia campestris L. (AC) leaves are widely recognized for their importance in traditional medicine. Despite the considerable amount of research conducted on this plant overworld, the chemical composition and the biological activity of t...
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| مؤلفون آخرون: | , , , , , , |
| منشور في: |
2024
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| _version_ | 1864513546050600960 |
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| author | Inès Limam (21393527) |
| author2 | Ridha Ghali (21393530) Mohamed Abdelkarim (169772) Anis Ouni (18497755) Manel Araoud (18497758) Mouaadh Abdelkarim (17541390) Abderrazek Hedhili (21393533) Fatma Ben-Aissa Fennira (21393536) |
| author2_role | author author author author author author author |
| author_facet | Inès Limam (21393527) Ridha Ghali (21393530) Mohamed Abdelkarim (169772) Anis Ouni (18497755) Manel Araoud (18497758) Mouaadh Abdelkarim (17541390) Abderrazek Hedhili (21393533) Fatma Ben-Aissa Fennira (21393536) |
| author_role | author |
| dc.creator.none.fl_str_mv | Inès Limam (21393527) Ridha Ghali (21393530) Mohamed Abdelkarim (169772) Anis Ouni (18497755) Manel Araoud (18497758) Mouaadh Abdelkarim (17541390) Abderrazek Hedhili (21393533) Fatma Ben-Aissa Fennira (21393536) |
| dc.date.none.fl_str_mv | 2024-05-02T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s13007-024-01185-4 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Tunisian_Artemisia_campestris_L_a_potential_therapeutic_agent_against_myeloma_-_phytochemical_and_pharmacological_insights/29108996 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Agricultural, veterinary and food sciences Food sciences Biological sciences Microbiology Biomedical and clinical sciences Medical biotechnology Oncology and carcinogenesis Environmental sciences Environmental biotechnology Artemisia campestris Polyphenol Phytosterol Terpene Antioxidant Anticancer Multiple myeloma Antibacterial Antifungal |
| dc.title.none.fl_str_mv | Tunisian Artemisia campestris L.: a potential therapeutic agent against myeloma - phytochemical and pharmacological insights |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Artemisia campestris L. (AC) leaves are widely recognized for their importance in traditional medicine. Despite the considerable amount of research conducted on this plant overworld, the chemical composition and the biological activity of the leaves grown in Tunisia remains poorly investigated. In this study of AC, a successive extraction method was employed (hexane, ethyl acetate and methanol) to investigate its bioactive constituents by LC-MS analysis, and their antioxidant, antibacterial, antifungal, and anticancer activities.</p><h3>Results</h3><p dir="ltr">Data analysis revealed diverse compound profiles in AC extracts. Methanolic and ethyl acetate extracts exhibited higher polyphenolic content and antioxidant activities, while Hexane showed superior phytosterol extraction. Ethyl acetate extract displayed potent antibacterial activity against multi-resistant <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>. Additionally, all extracts demonstrated, for the first time, robust antifungal efficacy against <i>Aspergillus flavus</i> and <i>Aspergillus niger</i>. Cytotoxicity assays revealed the significant impact of methanolic and ethyl acetate extracts on metastatic breast cancer and multiple myeloma, examined for the first time in our study. Moreover, further analysis on multiple myeloma cells highlighted that the ethyl acetate extract induced apoptotic and necrotic cell death and resulted in an S phase cell cycle blockage, underscoring its therapeutic potential.</p><h3>Conclusions</h3><p dir="ltr">This investigation uncovers novel findings in Tunisian AC, notably the identification of lupeol, oleanolic acid, ursolic acid, stigmasterol and β-sitosterol. The study sheds light on the promising role of AC extracts in therapeutic interventions and underscores the need for continued research to harness its full potential in medicine and pharmaceutical development.</p><h2>Other Information</h2><p dir="ltr">Published in: Plant Methods<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s13007-024-01185-4" target="_blank">https://dx.doi.org/10.1186/s13007-024-01185-4</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_3db6482aacb997588a9030815922517e |
| identifier_str_mv | 10.1186/s13007-024-01185-4 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29108996 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Tunisian Artemisia campestris L.: a potential therapeutic agent against myeloma - phytochemical and pharmacological insightsInès Limam (21393527)Ridha Ghali (21393530)Mohamed Abdelkarim (169772)Anis Ouni (18497755)Manel Araoud (18497758)Mouaadh Abdelkarim (17541390)Abderrazek Hedhili (21393533)Fatma Ben-Aissa Fennira (21393536)Agricultural, veterinary and food sciencesFood sciencesBiological sciencesMicrobiologyBiomedical and clinical sciencesMedical biotechnologyOncology and carcinogenesisEnvironmental sciencesEnvironmental biotechnologyArtemisia campestrisPolyphenolPhytosterolTerpeneAntioxidantAnticancerMultiple myelomaAntibacterialAntifungal<h3>Background</h3><p dir="ltr">Artemisia campestris L. (AC) leaves are widely recognized for their importance in traditional medicine. Despite the considerable amount of research conducted on this plant overworld, the chemical composition and the biological activity of the leaves grown in Tunisia remains poorly investigated. In this study of AC, a successive extraction method was employed (hexane, ethyl acetate and methanol) to investigate its bioactive constituents by LC-MS analysis, and their antioxidant, antibacterial, antifungal, and anticancer activities.</p><h3>Results</h3><p dir="ltr">Data analysis revealed diverse compound profiles in AC extracts. Methanolic and ethyl acetate extracts exhibited higher polyphenolic content and antioxidant activities, while Hexane showed superior phytosterol extraction. Ethyl acetate extract displayed potent antibacterial activity against multi-resistant <i>Staphylococcus aureus</i> and <i>Pseudomonas aeruginosa</i>. Additionally, all extracts demonstrated, for the first time, robust antifungal efficacy against <i>Aspergillus flavus</i> and <i>Aspergillus niger</i>. Cytotoxicity assays revealed the significant impact of methanolic and ethyl acetate extracts on metastatic breast cancer and multiple myeloma, examined for the first time in our study. Moreover, further analysis on multiple myeloma cells highlighted that the ethyl acetate extract induced apoptotic and necrotic cell death and resulted in an S phase cell cycle blockage, underscoring its therapeutic potential.</p><h3>Conclusions</h3><p dir="ltr">This investigation uncovers novel findings in Tunisian AC, notably the identification of lupeol, oleanolic acid, ursolic acid, stigmasterol and β-sitosterol. The study sheds light on the promising role of AC extracts in therapeutic interventions and underscores the need for continued research to harness its full potential in medicine and pharmaceutical development.</p><h2>Other Information</h2><p dir="ltr">Published in: Plant Methods<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1186/s13007-024-01185-4" target="_blank">https://dx.doi.org/10.1186/s13007-024-01185-4</a></p>2024-05-02T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s13007-024-01185-4https://figshare.com/articles/journal_contribution/Tunisian_Artemisia_campestris_L_a_potential_therapeutic_agent_against_myeloma_-_phytochemical_and_pharmacological_insights/29108996CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/291089962024-05-02T03:00:00Z |
| spellingShingle | Tunisian Artemisia campestris L.: a potential therapeutic agent against myeloma - phytochemical and pharmacological insights Inès Limam (21393527) Agricultural, veterinary and food sciences Food sciences Biological sciences Microbiology Biomedical and clinical sciences Medical biotechnology Oncology and carcinogenesis Environmental sciences Environmental biotechnology Artemisia campestris Polyphenol Phytosterol Terpene Antioxidant Anticancer Multiple myeloma Antibacterial Antifungal |
| status_str | publishedVersion |
| title | Tunisian Artemisia campestris L.: a potential therapeutic agent against myeloma - phytochemical and pharmacological insights |
| title_full | Tunisian Artemisia campestris L.: a potential therapeutic agent against myeloma - phytochemical and pharmacological insights |
| title_fullStr | Tunisian Artemisia campestris L.: a potential therapeutic agent against myeloma - phytochemical and pharmacological insights |
| title_full_unstemmed | Tunisian Artemisia campestris L.: a potential therapeutic agent against myeloma - phytochemical and pharmacological insights |
| title_short | Tunisian Artemisia campestris L.: a potential therapeutic agent against myeloma - phytochemical and pharmacological insights |
| title_sort | Tunisian Artemisia campestris L.: a potential therapeutic agent against myeloma - phytochemical and pharmacological insights |
| topic | Agricultural, veterinary and food sciences Food sciences Biological sciences Microbiology Biomedical and clinical sciences Medical biotechnology Oncology and carcinogenesis Environmental sciences Environmental biotechnology Artemisia campestris Polyphenol Phytosterol Terpene Antioxidant Anticancer Multiple myeloma Antibacterial Antifungal |