A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations
<p dir="ltr">Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ) are the downstream effectors of the Hippo signaling pathway that play a crucial role in various aspects of cancer progression including metastasis. Metastasis is the multistep proc...
Saved in:
| Main Author: | |
|---|---|
| Other Authors: | |
| Published: |
2020
|
| Subjects: | |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1864513512313716736 |
|---|---|
| author | Hirohito Yamaguchi (14884460) |
| author2 | Ghina M. Taouk (18891673) |
| author2_role | author |
| author_facet | Hirohito Yamaguchi (14884460) Ghina M. Taouk (18891673) |
| author_role | author |
| dc.creator.none.fl_str_mv | Hirohito Yamaguchi (14884460) Ghina M. Taouk (18891673) |
| dc.date.none.fl_str_mv | 2020-06-11T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fonc.2020.00928 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/A_Potential_Role_of_YAP_TAZ_in_the_Interplay_Between_Metastasis_and_Metabolic_Alterations/26114440 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Medical biochemistry and metabolomics Oncology and carcinogenesis YAP TAZ cancer metabolism metastasis |
| dc.title.none.fl_str_mv | A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ) are the downstream effectors of the Hippo signaling pathway that play a crucial role in various aspects of cancer progression including metastasis. Metastasis is the multistep process of disseminating cancer cells in a body and responsible for the majority of cancer-related death. Emerging evidence has shown that cancer cells reprogram their metabolism to gain proliferation, invasion, migration, and anti-apoptotic abilities and adapt to various environment during metastasis. Moreover, it has increasingly been recognized that YAP/TAZ regulates cellular metabolism that is associated with the phenotypic changes, and recent studies suggest that the YAP/TAZ-mediated metabolic alterations contribute to metastasis. In this review, we will introduce the latest knowledge of YAP/TAZ regulation and function in cancer metastasis and metabolism, and discuss possible links between the YAP/TAZ-mediated metabolic reprogramming and metastasis.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Oncology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fonc.2020.00928" target="_blank">https://dx.doi.org/10.3389/fonc.2020.00928</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_3dd3e48ef40403d52b410e6c94fe18dd |
| identifier_str_mv | 10.3389/fonc.2020.00928 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26114440 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic AlterationsHirohito Yamaguchi (14884460)Ghina M. Taouk (18891673)Biological sciencesBiochemistry and cell biologyBiomedical and clinical sciencesMedical biochemistry and metabolomicsOncology and carcinogenesisYAPTAZcancermetabolismmetastasis<p dir="ltr">Yes-Associated Protein (YAP) and Transcriptional Co-activator with PDZ-binding Motif (TAZ) are the downstream effectors of the Hippo signaling pathway that play a crucial role in various aspects of cancer progression including metastasis. Metastasis is the multistep process of disseminating cancer cells in a body and responsible for the majority of cancer-related death. Emerging evidence has shown that cancer cells reprogram their metabolism to gain proliferation, invasion, migration, and anti-apoptotic abilities and adapt to various environment during metastasis. Moreover, it has increasingly been recognized that YAP/TAZ regulates cellular metabolism that is associated with the phenotypic changes, and recent studies suggest that the YAP/TAZ-mediated metabolic alterations contribute to metastasis. In this review, we will introduce the latest knowledge of YAP/TAZ regulation and function in cancer metastasis and metabolism, and discuss possible links between the YAP/TAZ-mediated metabolic reprogramming and metastasis.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Oncology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fonc.2020.00928" target="_blank">https://dx.doi.org/10.3389/fonc.2020.00928</a></p>2020-06-11T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fonc.2020.00928https://figshare.com/articles/journal_contribution/A_Potential_Role_of_YAP_TAZ_in_the_Interplay_Between_Metastasis_and_Metabolic_Alterations/26114440CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/261144402020-06-11T06:00:00Z |
| spellingShingle | A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations Hirohito Yamaguchi (14884460) Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Medical biochemistry and metabolomics Oncology and carcinogenesis YAP TAZ cancer metabolism metastasis |
| status_str | publishedVersion |
| title | A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations |
| title_full | A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations |
| title_fullStr | A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations |
| title_full_unstemmed | A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations |
| title_short | A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations |
| title_sort | A Potential Role of YAP/TAZ in the Interplay Between Metastasis and Metabolic Alterations |
| topic | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Medical biochemistry and metabolomics Oncology and carcinogenesis YAP TAZ cancer metabolism metastasis |