Precision meets repurposing: Innovative approaches in human papillomavirus and Epstein-Barr virus-driven cancer therapy
<p dir="ltr">Viral <u>malignancies</u> represent a distinct entity among cancers. Oncoviruses like the <u>Human Papilloma Virus</u> (HPV) and the <u>Epstein Barr Virus</u> (EBV) are highly potent inducers of oncogenic transformation leading to tumo...
محفوظ في:
| المؤلف الرئيسي: | |
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| منشور في: |
2024
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513539589275648 |
|---|---|
| author | Queenie Fernandes (14557388) |
| author_facet | Queenie Fernandes (14557388) |
| author_role | author |
| dc.creator.none.fl_str_mv | Queenie Fernandes (14557388) |
| dc.date.none.fl_str_mv | 2024-11-18T15:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.canlet.2024.217318 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Precision_meets_repurposing_Innovative_approaches_in_human_papillomavirus_and_Epstein-Barr_virus-driven_cancer_therapy/30172924 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Immunology Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Oncoviruses HPV-Associated cancer EBV-Associated cancer Metronomic chemotherapy Drug repurposing |
| dc.title.none.fl_str_mv | Precision meets repurposing: Innovative approaches in human papillomavirus and Epstein-Barr virus-driven cancer therapy |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Viral <u>malignancies</u> represent a distinct entity among cancers. Oncoviruses like the <u>Human Papilloma Virus</u> (HPV) and the <u>Epstein Barr Virus</u> (EBV) are highly potent inducers of oncogenic transformation leading to tumor development. HPV and EBV are known to be increasingly involved in the pathogenesis of various classes of cancers like cervical, head and neck, colorectal, breast, oral and anogenitial. Therapeutic vaccines directed at such oncoviruses, often fail to unleash the desired immune response against the tumor. This is largely due to the<u> immunosuppressive</u> microenvironment of the virus-induced tumors. Consequently, metronomic chemotherapies administered in conjunction with therapeutic viral vaccines have considerably enhanced the <u>antitumor activity</u> of these vaccines. Moreover, given the unique attributes of HPV and EBV-associated cancers, therapeutic agents directly targeting the <u>oncoproteins</u> of these viruses are still obscure. In this light, an increasing number of reports have evidenced the <u>repurposing</u> of drugs for therapeutic benefits in such cancers. This work delineates the significance and implications of metronomic chemotherapy and<u> drug repurposing </u>in HPV and EBV-associated cancers.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancer Letters<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.canlet.2024.217318" target="_blank">https://dx.doi.org/10.1016/j.canlet.2024.217318</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_3e3d5dbd51832eb292ae48a213fa9cc6 |
| identifier_str_mv | 10.1016/j.canlet.2024.217318 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30172924 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Precision meets repurposing: Innovative approaches in human papillomavirus and Epstein-Barr virus-driven cancer therapyQueenie Fernandes (14557388)Biomedical and clinical sciencesImmunologyOncology and carcinogenesisPharmacology and pharmaceutical sciencesOncovirusesHPV-Associated cancerEBV-Associated cancerMetronomic chemotherapyDrug repurposing<p dir="ltr">Viral <u>malignancies</u> represent a distinct entity among cancers. Oncoviruses like the <u>Human Papilloma Virus</u> (HPV) and the <u>Epstein Barr Virus</u> (EBV) are highly potent inducers of oncogenic transformation leading to tumor development. HPV and EBV are known to be increasingly involved in the pathogenesis of various classes of cancers like cervical, head and neck, colorectal, breast, oral and anogenitial. Therapeutic vaccines directed at such oncoviruses, often fail to unleash the desired immune response against the tumor. This is largely due to the<u> immunosuppressive</u> microenvironment of the virus-induced tumors. Consequently, metronomic chemotherapies administered in conjunction with therapeutic viral vaccines have considerably enhanced the <u>antitumor activity</u> of these vaccines. Moreover, given the unique attributes of HPV and EBV-associated cancers, therapeutic agents directly targeting the <u>oncoproteins</u> of these viruses are still obscure. In this light, an increasing number of reports have evidenced the <u>repurposing</u> of drugs for therapeutic benefits in such cancers. This work delineates the significance and implications of metronomic chemotherapy and<u> drug repurposing </u>in HPV and EBV-associated cancers.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancer Letters<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.canlet.2024.217318" target="_blank">https://dx.doi.org/10.1016/j.canlet.2024.217318</a></p>2024-11-18T15:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.canlet.2024.217318https://figshare.com/articles/journal_contribution/Precision_meets_repurposing_Innovative_approaches_in_human_papillomavirus_and_Epstein-Barr_virus-driven_cancer_therapy/30172924CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/301729242024-11-18T15:00:00Z |
| spellingShingle | Precision meets repurposing: Innovative approaches in human papillomavirus and Epstein-Barr virus-driven cancer therapy Queenie Fernandes (14557388) Biomedical and clinical sciences Immunology Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Oncoviruses HPV-Associated cancer EBV-Associated cancer Metronomic chemotherapy Drug repurposing |
| status_str | publishedVersion |
| title | Precision meets repurposing: Innovative approaches in human papillomavirus and Epstein-Barr virus-driven cancer therapy |
| title_full | Precision meets repurposing: Innovative approaches in human papillomavirus and Epstein-Barr virus-driven cancer therapy |
| title_fullStr | Precision meets repurposing: Innovative approaches in human papillomavirus and Epstein-Barr virus-driven cancer therapy |
| title_full_unstemmed | Precision meets repurposing: Innovative approaches in human papillomavirus and Epstein-Barr virus-driven cancer therapy |
| title_short | Precision meets repurposing: Innovative approaches in human papillomavirus and Epstein-Barr virus-driven cancer therapy |
| title_sort | Precision meets repurposing: Innovative approaches in human papillomavirus and Epstein-Barr virus-driven cancer therapy |
| topic | Biomedical and clinical sciences Immunology Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Oncoviruses HPV-Associated cancer EBV-Associated cancer Metronomic chemotherapy Drug repurposing |