PGLM: Piecewise Generalized Linear Modeling of Ventricular Repolarization for Estimation of ECG T-wave Alternans
<p dir="ltr">In ECG signals, T-wave alternans (TWA) are attributed to the variations in amplitude, phase, or shape of every alternating T- wave. TWA has been associated with lethal cardiac arrhythmia leading to sudden cardiac death (SCD). In cardiac research, TWA refers to microscopi...
محفوظ في:
| المؤلف الرئيسي: | |
|---|---|
| مؤلفون آخرون: | , , , |
| منشور في: |
2025
|
| الموضوعات: | |
| الوسوم: |
إضافة وسم
لا توجد وسوم, كن أول من يضع وسما على هذه التسجيلة!
|
| _version_ | 1864513543671382016 |
|---|---|
| author | Ali Raza (21170873) |
| author2 | Ehsan Ullah (2698921) Kamran Javed (21726248) Muhammad Majid (5514389) Zubair Saeed (21643556) |
| author2_role | author author author author |
| author_facet | Ali Raza (21170873) Ehsan Ullah (2698921) Kamran Javed (21726248) Muhammad Majid (5514389) Zubair Saeed (21643556) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ali Raza (21170873) Ehsan Ullah (2698921) Kamran Javed (21726248) Muhammad Majid (5514389) Zubair Saeed (21643556) |
| dc.date.none.fl_str_mv | 2025-07-15T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1186/s13634-025-01227-6 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/PGLM_Piecewise_Generalized_Linear_Modeling_of_Ventricular_Repolarization_for_Estimation_of_ECG_T-wave_Alternans/29581193 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Engineering Biomedical engineering Communications engineering Electrocardiogram T-wave Alternans Modified moving average method Cardiac Arrhythmia Signal Processing |
| dc.title.none.fl_str_mv | PGLM: Piecewise Generalized Linear Modeling of Ventricular Repolarization for Estimation of ECG T-wave Alternans |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">In ECG signals, T-wave alternans (TWA) are attributed to the variations in amplitude, phase, or shape of every alternating T- wave. TWA has been associated with lethal cardiac arrhythmia leading to sudden cardiac death (SCD). In cardiac research, TWA refers to microscopic TWA as its amplitude ranges in microvolts (ţV). Detection and estimation of TWA in embed noises are still challenging as require elaborated signal processing techniques. Cardiac signals are non-stationary and least-squares methods have an edge over spectral methods as signals’ nature is not compromised. This study presents a new piecewise generalized linear modeling (PGLM) for TWA estimation by exploiting Runge’s phenomenon associated with a higher-order polynomial. A comparative study of the proposed PGLM and least-squares polynomial modeling (LSPM) with the modified moving average method (MMAM) as a benchmark method is also presented. The LSPM requires a higher-order polynomial for TWA estimation and suffers signal oscillation at junction points due to Runge’s phenomenon. The proposed model outperforms MMAM for TWA estimation for a noise range of 10–40 dB with TWA amplitude variations 5–100 microvolts for stationary, non-stationary, and phase-changing TWA. The PGLM is computationally simpler and presents a powerful technique for TWA amplitude estimation for the clinical study of cardiac arrhythmia.</p><h2>Other Information</h2><p dir="ltr">Published in: EURASIP Journal on Advances in Signal Processing<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://doi.org/10.1186/s13634-025-01227-6" target="_blank">https://doi.org/10.1186/s13634-025-01227-6</a></p><p dir="ltr">Additional institutions affiliated with: Department of Electrical and Computer Engineering - TAMUQ</p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_3e9b8f577d87dc0f1b0fd3896016f2ae |
| identifier_str_mv | 10.1186/s13634-025-01227-6 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29581193 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | PGLM: Piecewise Generalized Linear Modeling of Ventricular Repolarization for Estimation of ECG T-wave AlternansAli Raza (21170873)Ehsan Ullah (2698921)Kamran Javed (21726248)Muhammad Majid (5514389)Zubair Saeed (21643556)Biomedical and clinical sciencesCardiovascular medicine and haematologyEngineeringBiomedical engineeringCommunications engineeringElectrocardiogramT-wave AlternansModified moving average methodCardiac ArrhythmiaSignal Processing<p dir="ltr">In ECG signals, T-wave alternans (TWA) are attributed to the variations in amplitude, phase, or shape of every alternating T- wave. TWA has been associated with lethal cardiac arrhythmia leading to sudden cardiac death (SCD). In cardiac research, TWA refers to microscopic TWA as its amplitude ranges in microvolts (ţV). Detection and estimation of TWA in embed noises are still challenging as require elaborated signal processing techniques. Cardiac signals are non-stationary and least-squares methods have an edge over spectral methods as signals’ nature is not compromised. This study presents a new piecewise generalized linear modeling (PGLM) for TWA estimation by exploiting Runge’s phenomenon associated with a higher-order polynomial. A comparative study of the proposed PGLM and least-squares polynomial modeling (LSPM) with the modified moving average method (MMAM) as a benchmark method is also presented. The LSPM requires a higher-order polynomial for TWA estimation and suffers signal oscillation at junction points due to Runge’s phenomenon. The proposed model outperforms MMAM for TWA estimation for a noise range of 10–40 dB with TWA amplitude variations 5–100 microvolts for stationary, non-stationary, and phase-changing TWA. The PGLM is computationally simpler and presents a powerful technique for TWA amplitude estimation for the clinical study of cardiac arrhythmia.</p><h2>Other Information</h2><p dir="ltr">Published in: EURASIP Journal on Advances in Signal Processing<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://doi.org/10.1186/s13634-025-01227-6" target="_blank">https://doi.org/10.1186/s13634-025-01227-6</a></p><p dir="ltr">Additional institutions affiliated with: Department of Electrical and Computer Engineering - TAMUQ</p>2025-07-15T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1186/s13634-025-01227-6https://figshare.com/articles/journal_contribution/PGLM_Piecewise_Generalized_Linear_Modeling_of_Ventricular_Repolarization_for_Estimation_of_ECG_T-wave_Alternans/29581193CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/295811932025-07-15T00:00:00Z |
| spellingShingle | PGLM: Piecewise Generalized Linear Modeling of Ventricular Repolarization for Estimation of ECG T-wave Alternans Ali Raza (21170873) Biomedical and clinical sciences Cardiovascular medicine and haematology Engineering Biomedical engineering Communications engineering Electrocardiogram T-wave Alternans Modified moving average method Cardiac Arrhythmia Signal Processing |
| status_str | publishedVersion |
| title | PGLM: Piecewise Generalized Linear Modeling of Ventricular Repolarization for Estimation of ECG T-wave Alternans |
| title_full | PGLM: Piecewise Generalized Linear Modeling of Ventricular Repolarization for Estimation of ECG T-wave Alternans |
| title_fullStr | PGLM: Piecewise Generalized Linear Modeling of Ventricular Repolarization for Estimation of ECG T-wave Alternans |
| title_full_unstemmed | PGLM: Piecewise Generalized Linear Modeling of Ventricular Repolarization for Estimation of ECG T-wave Alternans |
| title_short | PGLM: Piecewise Generalized Linear Modeling of Ventricular Repolarization for Estimation of ECG T-wave Alternans |
| title_sort | PGLM: Piecewise Generalized Linear Modeling of Ventricular Repolarization for Estimation of ECG T-wave Alternans |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Engineering Biomedical engineering Communications engineering Electrocardiogram T-wave Alternans Modified moving average method Cardiac Arrhythmia Signal Processing |