Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway

Sanguinarine mediated apoptosis in Non-Small Cell Lung Cancer via generation of reactive oxygen species and suppression of JAK/STAT pathway

<p dir="ltr">Effective treatment of lung cancer remains a significant clinical challenge due to its multidrug resistance and side effects of the current treatment options. The high mortality associated with this malignancy indicates the need for new therapeutic interventions with few...

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Main Author: Kirti.S. Prabhu (17191231) (author)
Other Authors: Ajaz A. Bhat (12984701) (author), Kodappully S. Siveen (4246150) (author), Shilpa Kuttikrishnan (3520079) (author), Syed Shadab Raza (5775911) (author), Thesni Raheed (17017779) (author), Anh Jochebeth (17017782) (author), Abdul Q. Khan (14153247) (author), M.Zafar Chawdhery (17191234) (author), Mohammad Haris (564809) (author), Michal Kulinski (3520070) (author), Said Dermime (79420) (author), Martin Steinhoff (5340194) (author), Shahab Uddin (154400) (author)
Published: 2021
Subjects:
Biomedical and clinical sciences
Cardiovascular medicine and haematology
Oncology and carcinogenesis
Pharmacology and pharmaceutical sciences
Apoptosis
Antiproliferative
Alkaloids
Antioxidants
Cancer stem cells
Sanguinarine
ROS
STAT3
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