Assessment of Drug-Induced QTc Prolongation in Mental Health Practice: Validation of an Evidence-Based Algorithm
<h3>Background</h3><h3><p dir="ltr">Drug-induced QTc interval prolongation (QTcIP) can lead to serious consequences and is often a concern for mental health practitioners, as access to experts such as cardiologists, for consultation is time-limiting and can delay tr...
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| مؤلفون آخرون: | , , , , , , , , |
| منشور في: |
2023
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| الموضوعات: | |
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| _version_ | 1864513535758827520 |
|---|---|
| author | Monica Zolezzi (10115698) |
| author2 | Athar Elhakim (17541522) Iman Qubaiah (17541666) Doaa Mahmoud (17541669) Shorouq Homs (17541672) Waad Elamin (17541675) Engy Tawfik (17541678) Oraib Abdallah (12506762) Yassin Eltorki (9617390) Noriya Al-Khuzaei (12506777) |
| author2_role | author author author author author author author author author |
| author_facet | Monica Zolezzi (10115698) Athar Elhakim (17541522) Iman Qubaiah (17541666) Doaa Mahmoud (17541669) Shorouq Homs (17541672) Waad Elamin (17541675) Engy Tawfik (17541678) Oraib Abdallah (12506762) Yassin Eltorki (9617390) Noriya Al-Khuzaei (12506777) |
| author_role | author |
| dc.creator.none.fl_str_mv | Monica Zolezzi (10115698) Athar Elhakim (17541522) Iman Qubaiah (17541666) Doaa Mahmoud (17541669) Shorouq Homs (17541672) Waad Elamin (17541675) Engy Tawfik (17541678) Oraib Abdallah (12506762) Yassin Eltorki (9617390) Noriya Al-Khuzaei (12506777) |
| dc.date.none.fl_str_mv | 2023-10-13T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.2147/rmhp.s426591 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Assessment_of_Drug-Induced_QTc_Prolongation_in_Mental_Health_Practice_Validation_of_an_Evidence-Based_Algorithm/24717318 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Health sciences Health services and systems drug-induced arrhythmias QTc interval prolongation algorithm mental health practice clinical decision tool |
| dc.title.none.fl_str_mv | Assessment of Drug-Induced QTc Prolongation in Mental Health Practice: Validation of an Evidence-Based Algorithm |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><h3><p dir="ltr">Drug-induced QTc interval prolongation (QTcIP) can lead to serious consequences and is often a concern for mental health practitioners, as access to experts such as cardiologists, for consultation is time-limiting and can delay treatment decisions. This research aimed at validating the content of an algorithm for the assessment, management and monitoring of drug-induced QTcIP in mental health practice.</p></h3><h3>Methods</h3><h3><p dir="ltr">Following an initial face validity by content experts, a cross-sectional survey of mental health care practitioners with a 4-point Likert-type scale was used to assess the validity of the decision steps on the QTcIP algorithm (QTcIPA) by estimating the content validity index (CVI) and the modified kappa statistic (κ*). Participants’ open-ended comments were also thematically analyzed.</p></h3><h3>Results</h3><h3><p dir="ltr">Mental health practitioners found the QTcIPA to be appropriate, safe, and evidence-based, as indicated by the high individual item CVI scores ranging from 0.89 to 1 for all of the steps/decision statements in the three domains assessed: appropriateness, safety and reliability of the references used. Five themes emerged from the qualitative analysis of the open-ended comments, of which three were identified as strengths, including practical usability, reliable references and beneficial for pharmacists. Two themes were recognized as limitations, namely, the need for additional clinical content and application barriers.</p></h3><h3>Conclusion</h3><h3><p dir="ltr">These results suggest that the QTcIPA may be a useful tool for mental health clinicians at the time of prescribing medications with potential risk of QTcIP. Future research will explore the implementation of the QTcIPA into clinical practice using computerized decision support tools through web-based and mobile applications.</p></h3><h2>Other Information</h2><p dir="ltr">Published in: Risk Management and Healthcare Policy<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.2147/rmhp.s426591" target="_blank">https://dx.doi.org/10.2147/rmhp.s426591</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_3ed90b8d382bf2f2dca63564306f6595 |
| identifier_str_mv | 10.2147/rmhp.s426591 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24717318 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Assessment of Drug-Induced QTc Prolongation in Mental Health Practice: Validation of an Evidence-Based AlgorithmMonica Zolezzi (10115698)Athar Elhakim (17541522)Iman Qubaiah (17541666)Doaa Mahmoud (17541669)Shorouq Homs (17541672)Waad Elamin (17541675)Engy Tawfik (17541678)Oraib Abdallah (12506762)Yassin Eltorki (9617390)Noriya Al-Khuzaei (12506777)Biomedical and clinical sciencesClinical sciencesPharmacology and pharmaceutical sciencesHealth sciencesHealth services and systemsdrug-induced arrhythmiasQTc interval prolongationalgorithmmental health practiceclinical decision tool<h3>Background</h3><h3><p dir="ltr">Drug-induced QTc interval prolongation (QTcIP) can lead to serious consequences and is often a concern for mental health practitioners, as access to experts such as cardiologists, for consultation is time-limiting and can delay treatment decisions. This research aimed at validating the content of an algorithm for the assessment, management and monitoring of drug-induced QTcIP in mental health practice.</p></h3><h3>Methods</h3><h3><p dir="ltr">Following an initial face validity by content experts, a cross-sectional survey of mental health care practitioners with a 4-point Likert-type scale was used to assess the validity of the decision steps on the QTcIP algorithm (QTcIPA) by estimating the content validity index (CVI) and the modified kappa statistic (κ*). Participants’ open-ended comments were also thematically analyzed.</p></h3><h3>Results</h3><h3><p dir="ltr">Mental health practitioners found the QTcIPA to be appropriate, safe, and evidence-based, as indicated by the high individual item CVI scores ranging from 0.89 to 1 for all of the steps/decision statements in the three domains assessed: appropriateness, safety and reliability of the references used. Five themes emerged from the qualitative analysis of the open-ended comments, of which three were identified as strengths, including practical usability, reliable references and beneficial for pharmacists. Two themes were recognized as limitations, namely, the need for additional clinical content and application barriers.</p></h3><h3>Conclusion</h3><h3><p dir="ltr">These results suggest that the QTcIPA may be a useful tool for mental health clinicians at the time of prescribing medications with potential risk of QTcIP. Future research will explore the implementation of the QTcIPA into clinical practice using computerized decision support tools through web-based and mobile applications.</p></h3><h2>Other Information</h2><p dir="ltr">Published in: Risk Management and Healthcare Policy<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.2147/rmhp.s426591" target="_blank">https://dx.doi.org/10.2147/rmhp.s426591</a></p>2023-10-13T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.2147/rmhp.s426591https://figshare.com/articles/journal_contribution/Assessment_of_Drug-Induced_QTc_Prolongation_in_Mental_Health_Practice_Validation_of_an_Evidence-Based_Algorithm/24717318CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/247173182023-10-13T03:00:00Z |
| spellingShingle | Assessment of Drug-Induced QTc Prolongation in Mental Health Practice: Validation of an Evidence-Based Algorithm Monica Zolezzi (10115698) Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Health sciences Health services and systems drug-induced arrhythmias QTc interval prolongation algorithm mental health practice clinical decision tool |
| status_str | publishedVersion |
| title | Assessment of Drug-Induced QTc Prolongation in Mental Health Practice: Validation of an Evidence-Based Algorithm |
| title_full | Assessment of Drug-Induced QTc Prolongation in Mental Health Practice: Validation of an Evidence-Based Algorithm |
| title_fullStr | Assessment of Drug-Induced QTc Prolongation in Mental Health Practice: Validation of an Evidence-Based Algorithm |
| title_full_unstemmed | Assessment of Drug-Induced QTc Prolongation in Mental Health Practice: Validation of an Evidence-Based Algorithm |
| title_short | Assessment of Drug-Induced QTc Prolongation in Mental Health Practice: Validation of an Evidence-Based Algorithm |
| title_sort | Assessment of Drug-Induced QTc Prolongation in Mental Health Practice: Validation of an Evidence-Based Algorithm |
| topic | Biomedical and clinical sciences Clinical sciences Pharmacology and pharmaceutical sciences Health sciences Health services and systems drug-induced arrhythmias QTc interval prolongation algorithm mental health practice clinical decision tool |