Myxedema psychosis A protocol for a systematic review and a pooled analysis
<h3>Background</h3><p dir="ltr">Myxedema psychosis (MP) is a rare presentation of hypothyroidism. Although known for >70 years, a significant lack of systematic literature describing this condition exists. This limits the clinician's ability to identify and manage...
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2020
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| _version_ | 1864513554036555776 |
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| author | Mouhand F.H. Mohamed (16932579) |
| author2 | Timo Siepmann (4349554) Salah Suwileh (17151034) Mohammed H. Mohammed (20351946) Samreen Mohamed (20351949) Lina O. Abdalla (9960494) Abdel-Naser Elzouki (9376853) Mohamed H. Mahmoud (12627835) Dabia Al-Mohanadi (17032269) Mohammed Danjuma (9960506) |
| author2_role | author author author author author author author author author |
| author_facet | Mouhand F.H. Mohamed (16932579) Timo Siepmann (4349554) Salah Suwileh (17151034) Mohammed H. Mohammed (20351946) Samreen Mohamed (20351949) Lina O. Abdalla (9960494) Abdel-Naser Elzouki (9376853) Mohamed H. Mahmoud (12627835) Dabia Al-Mohanadi (17032269) Mohammed Danjuma (9960506) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mouhand F.H. Mohamed (16932579) Timo Siepmann (4349554) Salah Suwileh (17151034) Mohammed H. Mohammed (20351946) Samreen Mohamed (20351949) Lina O. Abdalla (9960494) Abdel-Naser Elzouki (9376853) Mohamed H. Mahmoud (12627835) Dabia Al-Mohanadi (17032269) Mohammed Danjuma (9960506) |
| dc.date.none.fl_str_mv | 2020-06-26T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1097/md.0000000000020778 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Myxedema_psychosis_A_protocol_for_a_systematic_review_and_a_pooled_analysis/27924924 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Neurosciences hypothyroidism madness myxedema psychosis systematic review |
| dc.title.none.fl_str_mv | Myxedema psychosis A protocol for a systematic review and a pooled analysis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Myxedema psychosis (MP) is a rare presentation of hypothyroidism. Although known for >70 years, a significant lack of systematic literature describing this condition exists. This limits the clinician's ability to identify and manage this entity properly. Hence, we aimed to systematically review the literature and summarize the presentation, diagnosis, management, and outcomes of this rare entity.</p><h3>Methods</h3><p dir="ltr">Systematic review following PRISMA guidance. We will perform a comprehensive search of PubMed, Medline, Embase, Google Scholar (first 300 hits), and Cochrane databases for published observational studies, case series, and case reports. We will use descriptive statistics to provide summary estimates of demographics, common presenting features, laboratory test results, imaging findings, treatment administered, and outcomes. Moreover, continuous variables will be compared by the Wilcoxon Mann Whitney test, whereas categorical variables will be assessed by the <i>χ</i><sup>2</sup> test. Bivariate and multivariate regression will be performed to assess risk factors associated with poor outcome. A scoping review revealed that a meta-analysis might not be feasible owing to the paucity of systematic studies describing the condition.</p><h3>Results</h3><p dir="ltr">This is the first systematic review examining this rare entity. Thus, the result of which will be significant. We hope that this review will help in identifying relevant predictive clinical or laboratory characteristics. Additionally, it identifies the best treatment strategies. The findings of this review will help increase our knowledge of this condition so as to recognize this condition promptly. Also, it will assist in differentiating MP from masqueraders, such as Hashimoto encephalopathy (HE). The results of this review will be published in a peer-reviewed journal.</p><h3>Conclusion</h3><p dir="ltr">This is the first systematic review exploring MP demographics, diagnosis treatment, and outcomes. The information gathered by this review will be necessary for patients, clinicians, researchers, and guideline makers.</p><h3>PROSPERO registration number</h3><p dir="ltr">CRD42020160310</p><h2>Other Information</h2><p dir="ltr">Published in: Medicine<br>License: <a href="http://creativecommons.org/licenses/by/4.0" target="_blank">http://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1097/md.0000000000020778" target="_blank">https://dx.doi.org/10.1097/md.0000000000020778</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_400e5919227cd28a8e05cfe6690ffc5b |
| identifier_str_mv | 10.1097/md.0000000000020778 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/27924924 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Myxedema psychosis A protocol for a systematic review and a pooled analysisMouhand F.H. Mohamed (16932579)Timo Siepmann (4349554)Salah Suwileh (17151034)Mohammed H. Mohammed (20351946)Samreen Mohamed (20351949)Lina O. Abdalla (9960494)Abdel-Naser Elzouki (9376853)Mohamed H. Mahmoud (12627835)Dabia Al-Mohanadi (17032269)Mohammed Danjuma (9960506)Biomedical and clinical sciencesClinical sciencesMedical biochemistry and metabolomicsNeuroscienceshypothyroidismmadnessmyxedemapsychosissystematic review<h3>Background</h3><p dir="ltr">Myxedema psychosis (MP) is a rare presentation of hypothyroidism. Although known for >70 years, a significant lack of systematic literature describing this condition exists. This limits the clinician's ability to identify and manage this entity properly. Hence, we aimed to systematically review the literature and summarize the presentation, diagnosis, management, and outcomes of this rare entity.</p><h3>Methods</h3><p dir="ltr">Systematic review following PRISMA guidance. We will perform a comprehensive search of PubMed, Medline, Embase, Google Scholar (first 300 hits), and Cochrane databases for published observational studies, case series, and case reports. We will use descriptive statistics to provide summary estimates of demographics, common presenting features, laboratory test results, imaging findings, treatment administered, and outcomes. Moreover, continuous variables will be compared by the Wilcoxon Mann Whitney test, whereas categorical variables will be assessed by the <i>χ</i><sup>2</sup> test. Bivariate and multivariate regression will be performed to assess risk factors associated with poor outcome. A scoping review revealed that a meta-analysis might not be feasible owing to the paucity of systematic studies describing the condition.</p><h3>Results</h3><p dir="ltr">This is the first systematic review examining this rare entity. Thus, the result of which will be significant. We hope that this review will help in identifying relevant predictive clinical or laboratory characteristics. Additionally, it identifies the best treatment strategies. The findings of this review will help increase our knowledge of this condition so as to recognize this condition promptly. Also, it will assist in differentiating MP from masqueraders, such as Hashimoto encephalopathy (HE). The results of this review will be published in a peer-reviewed journal.</p><h3>Conclusion</h3><p dir="ltr">This is the first systematic review exploring MP demographics, diagnosis treatment, and outcomes. The information gathered by this review will be necessary for patients, clinicians, researchers, and guideline makers.</p><h3>PROSPERO registration number</h3><p dir="ltr">CRD42020160310</p><h2>Other Information</h2><p dir="ltr">Published in: Medicine<br>License: <a href="http://creativecommons.org/licenses/by/4.0" target="_blank">http://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1097/md.0000000000020778" target="_blank">https://dx.doi.org/10.1097/md.0000000000020778</a></p>2020-06-26T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1097/md.0000000000020778https://figshare.com/articles/journal_contribution/Myxedema_psychosis_A_protocol_for_a_systematic_review_and_a_pooled_analysis/27924924CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/279249242020-06-26T03:00:00Z |
| spellingShingle | Myxedema psychosis A protocol for a systematic review and a pooled analysis Mouhand F.H. Mohamed (16932579) Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Neurosciences hypothyroidism madness myxedema psychosis systematic review |
| status_str | publishedVersion |
| title | Myxedema psychosis A protocol for a systematic review and a pooled analysis |
| title_full | Myxedema psychosis A protocol for a systematic review and a pooled analysis |
| title_fullStr | Myxedema psychosis A protocol for a systematic review and a pooled analysis |
| title_full_unstemmed | Myxedema psychosis A protocol for a systematic review and a pooled analysis |
| title_short | Myxedema psychosis A protocol for a systematic review and a pooled analysis |
| title_sort | Myxedema psychosis A protocol for a systematic review and a pooled analysis |
| topic | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Neurosciences hypothyroidism madness myxedema psychosis systematic review |