Effects of paternal and chronological age on BEGAIN methylation and its possible role in autism
<p dir="ltr">Children from old fathers carry an increased risk for autism spectrum (ASD) and other neurodevelopmental disorders, which may at least partially be mediated by paternal age effects on the sperm epigenome. The brain enriched guanylate kinase associated (BEGAIN) protein is...
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| مؤلفون آخرون: | , , , , , , , , |
| منشور في: |
2023
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| _version_ | 1864513507191422976 |
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| author | Ramya Potabattula (4401160) |
| author2 | Andreas Prell (19479751) Marcus Dittrich (167737) Caroline Nava (529842) Christel Depienne (374545) Yosra Bejaoui (8552574) Nady El Hajj (686554) Thomas Hahn (146530) Martin Schorsch (686559) Thomas Haaf (342924) |
| author2_role | author author author author author author author author author |
| author_facet | Ramya Potabattula (4401160) Andreas Prell (19479751) Marcus Dittrich (167737) Caroline Nava (529842) Christel Depienne (374545) Yosra Bejaoui (8552574) Nady El Hajj (686554) Thomas Hahn (146530) Martin Schorsch (686559) Thomas Haaf (342924) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ramya Potabattula (4401160) Andreas Prell (19479751) Marcus Dittrich (167737) Caroline Nava (529842) Christel Depienne (374545) Yosra Bejaoui (8552574) Nady El Hajj (686554) Thomas Hahn (146530) Martin Schorsch (686559) Thomas Haaf (342924) |
| dc.date.none.fl_str_mv | 2023-11-28T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.18632/aging.205275 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Effects_of_paternal_and_chronological_age_on_BEGAIN_methylation_and_its_possible_role_in_autism/26827738 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Neurosciences age and sex effect autism spectrum disorder BEGAIN chronological aging paternal age effect sperm methylation |
| dc.title.none.fl_str_mv | Effects of paternal and chronological age on BEGAIN methylation and its possible role in autism |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Children from old fathers carry an increased risk for autism spectrum (ASD) and other neurodevelopmental disorders, which may at least partially be mediated by paternal age effects on the sperm epigenome. The brain enriched guanylate kinase associated (BEGAIN) protein is involved in protein-protein interactions at and transmission across synapses. Since several epigenome-wide methylation screens reported a paternal age effect on sperm <i>BEGAIN</i> methylation, here we confirmed a significant negative correlation between <i>BEGAIN</i> promoter methylation and paternal age, using more sensitive bisulfite pyrosequencing and a larger number of sperm samples. Paternal age-associated <i>BEGAIN</i> hypomethylation was also observed in fetal cord blood (FCB) of male but not of female offspring. There was no comparable maternal age effect on FCB methylation. In addition, we found a significant negative correlation between <i>BEGAIN</i> methylation and chronological age (ranging from 1 to 70 years) in peripheral blood samples of male but not of female donors. <i>BEGAIN</i> hypomethylation was more pronounced in male children, adolescents and adults suffering from ASD compared to controls. Both genetic variation (CC genotype of SNP rs7141087) and epigenetic factors may contribute to <i>BEGAIN</i> promoter hypomethylation. The age- and sex-specific <i>BEGAIN </i>methylation trajectories in the male germ line and somatic tissues, in particular the brain, support a role of this gene in ASD development.</p><h2>Other Information</h2><p dir="ltr">Published in: Aging<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.18632/aging.205275" target="_blank">https://dx.doi.org/10.18632/aging.205275</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_410a6a2fc17f9f44f8acc4054d81faa0 |
| identifier_str_mv | 10.18632/aging.205275 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26827738 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Effects of paternal and chronological age on BEGAIN methylation and its possible role in autismRamya Potabattula (4401160)Andreas Prell (19479751)Marcus Dittrich (167737)Caroline Nava (529842)Christel Depienne (374545)Yosra Bejaoui (8552574)Nady El Hajj (686554)Thomas Hahn (146530)Martin Schorsch (686559)Thomas Haaf (342924)Biological sciencesGeneticsBiomedical and clinical sciencesNeurosciencesage and sex effectautism spectrum disorderBEGAINchronological agingpaternal age effectsperm methylation<p dir="ltr">Children from old fathers carry an increased risk for autism spectrum (ASD) and other neurodevelopmental disorders, which may at least partially be mediated by paternal age effects on the sperm epigenome. The brain enriched guanylate kinase associated (BEGAIN) protein is involved in protein-protein interactions at and transmission across synapses. Since several epigenome-wide methylation screens reported a paternal age effect on sperm <i>BEGAIN</i> methylation, here we confirmed a significant negative correlation between <i>BEGAIN</i> promoter methylation and paternal age, using more sensitive bisulfite pyrosequencing and a larger number of sperm samples. Paternal age-associated <i>BEGAIN</i> hypomethylation was also observed in fetal cord blood (FCB) of male but not of female offspring. There was no comparable maternal age effect on FCB methylation. In addition, we found a significant negative correlation between <i>BEGAIN</i> methylation and chronological age (ranging from 1 to 70 years) in peripheral blood samples of male but not of female donors. <i>BEGAIN</i> hypomethylation was more pronounced in male children, adolescents and adults suffering from ASD compared to controls. Both genetic variation (CC genotype of SNP rs7141087) and epigenetic factors may contribute to <i>BEGAIN</i> promoter hypomethylation. The age- and sex-specific <i>BEGAIN </i>methylation trajectories in the male germ line and somatic tissues, in particular the brain, support a role of this gene in ASD development.</p><h2>Other Information</h2><p dir="ltr">Published in: Aging<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.18632/aging.205275" target="_blank">https://dx.doi.org/10.18632/aging.205275</a></p>2023-11-28T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.18632/aging.205275https://figshare.com/articles/journal_contribution/Effects_of_paternal_and_chronological_age_on_BEGAIN_methylation_and_its_possible_role_in_autism/26827738CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/268277382023-11-28T09:00:00Z |
| spellingShingle | Effects of paternal and chronological age on BEGAIN methylation and its possible role in autism Ramya Potabattula (4401160) Biological sciences Genetics Biomedical and clinical sciences Neurosciences age and sex effect autism spectrum disorder BEGAIN chronological aging paternal age effect sperm methylation |
| status_str | publishedVersion |
| title | Effects of paternal and chronological age on BEGAIN methylation and its possible role in autism |
| title_full | Effects of paternal and chronological age on BEGAIN methylation and its possible role in autism |
| title_fullStr | Effects of paternal and chronological age on BEGAIN methylation and its possible role in autism |
| title_full_unstemmed | Effects of paternal and chronological age on BEGAIN methylation and its possible role in autism |
| title_short | Effects of paternal and chronological age on BEGAIN methylation and its possible role in autism |
| title_sort | Effects of paternal and chronological age on BEGAIN methylation and its possible role in autism |
| topic | Biological sciences Genetics Biomedical and clinical sciences Neurosciences age and sex effect autism spectrum disorder BEGAIN chronological aging paternal age effect sperm methylation |