Follow‐Up and Comparative Assessment of SARS‐CoV‐2 IgA, IgG, Neutralizing, and Total Antibody Responses After BNT162b2 or mRNA‐1273 Heterologous Booster Vaccination
<h3>Background</h3><p dir="ltr">Priming with ChAdOx1 followed by heterologous boosting is considered in several countries. Nevertheless, analyses comparing the immunogenicity of heterologous booster to homologous primary vaccination regimens and natural infection are lack...
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2024
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| author | Salma Younes (6424865) |
| author2 | Eleonora Nicolai (496034) Massimo Pieri (5023022) Sergio Bernardini (504056) Hanin I. Daas (21841853) Duaa W. Al‐Sadeq (21841856) Nadin Younes (4863280) Farah M. Shurrab (21841859) Parveen B. Nizamuddin (21841862) Fathima Humaira (21841865) Nader Al‐Dewik (14777014) Hadi M. Yassine (21841868) Laith J. Abu‐Raddad (21841871) Ahmed Ismail (2671822) Gheyath K. Nasrallah (21841874) |
| author2_role | author author author author author author author author author author author author author author |
| author_facet | Salma Younes (6424865) Eleonora Nicolai (496034) Massimo Pieri (5023022) Sergio Bernardini (504056) Hanin I. Daas (21841853) Duaa W. Al‐Sadeq (21841856) Nadin Younes (4863280) Farah M. Shurrab (21841859) Parveen B. Nizamuddin (21841862) Fathima Humaira (21841865) Nader Al‐Dewik (14777014) Hadi M. Yassine (21841868) Laith J. Abu‐Raddad (21841871) Ahmed Ismail (2671822) Gheyath K. Nasrallah (21841874) |
| author_role | author |
| dc.creator.none.fl_str_mv | Salma Younes (6424865) Eleonora Nicolai (496034) Massimo Pieri (5023022) Sergio Bernardini (504056) Hanin I. Daas (21841853) Duaa W. Al‐Sadeq (21841856) Nadin Younes (4863280) Farah M. Shurrab (21841859) Parveen B. Nizamuddin (21841862) Fathima Humaira (21841865) Nader Al‐Dewik (14777014) Hadi M. Yassine (21841868) Laith J. Abu‐Raddad (21841871) Ahmed Ismail (2671822) Gheyath K. Nasrallah (21841874) |
| dc.date.none.fl_str_mv | 2024-05-06T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1111/irv.13290 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Follow_Up_and_Comparative_Assessment_of_SARS_CoV_2_IgA_IgG_Neutralizing_and_Total_Antibody_Responses_After_BNT162b2_or_mRNA_1273_Heterologous_Booster_Vaccination/29715341 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Immunology Health sciences Epidemiology Public health antibodies anti- S1-IgA anti- S-RBD IgG booster COVID-19 immune response neutralizing antibody vaccination |
| dc.title.none.fl_str_mv | Follow‐Up and Comparative Assessment of SARS‐CoV‐2 IgA, IgG, Neutralizing, and Total Antibody Responses After BNT162b2 or mRNA‐1273 Heterologous Booster Vaccination |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Priming with ChAdOx1 followed by heterologous boosting is considered in several countries. Nevertheless, analyses comparing the immunogenicity of heterologous booster to homologous primary vaccination regimens and natural infection are lacking. In this study, we aimed to conduct a comparative assessment of the immunogenicity between homologous primary vaccination regimens and heterologous prime‐boost vaccination using BNT162b2 or mRNA‐1273.</p><h3>Methods</h3><p dir="ltr">We matched vaccinated naïve (VN) individuals (<i>n</i> = 673) with partial vaccination (<i>n</i> = 64), primary vaccination (<i>n</i> = 590), and primary series plus mRNA vaccine heterologous booster (<i>n</i> = 19) with unvaccinated naturally infected (NI) individuals with a documented primary SARS‐CoV‐2 infection (<i>n</i> = 206). We measured the levels of neutralizing total antibodies (NTAbs), total antibodies (TAbs), anti‐S‐RBD IgG, and anti‐S1 IgA titers.</p><h3>Results</h3><p dir="ltr">Homologous primary vaccination with ChAdOx1 not only showed less potent NTAb, TAb, anti‐S‐RBD IgG, and anti‐S1 IgA immune responses compared to primary BNT162b2 or mRNA‐1273 vaccination regimens (<i>p</i> < 0.05) but also showed ~3‐fold less anti‐S1 IgA response compared to infection‐induced immunity (<i>p</i> < 0.001). Nevertheless, a heterologous booster led to an increase of ~12 times in the immune response when compared to two consecutive homologous ChAdOx1 immunizations. Furthermore, correlation analyses revealed that both anti‐S‐RBD IgG and anti‐S1 IgA significantly contributed to virus neutralization among NI individuals, particularly in symptomatic and pauci‐symptomatic individuals, whereas among VN individuals, anti‐S‐RBD IgG was the main contributor to virus neutralization.</p><h3>Conclusion</h3><p dir="ltr">The results emphasize the potential benefit of using heterologous mRNA boosters to increase antibody levels and neutralizing capacity particularly in patients who received primary vaccination with ChAdOx1.</p><h2>Other Information</h2><p dir="ltr">Published in: Influenza and Other Respiratory Viruses<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1111/irv.13290" target="_blank">https://dx.doi.org/10.1111/irv.13290</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_414f30723dc5f686d7af2b8cba844e11 |
| identifier_str_mv | 10.1111/irv.13290 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29715341 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Follow‐Up and Comparative Assessment of SARS‐CoV‐2 IgA, IgG, Neutralizing, and Total Antibody Responses After BNT162b2 or mRNA‐1273 Heterologous Booster VaccinationSalma Younes (6424865)Eleonora Nicolai (496034)Massimo Pieri (5023022)Sergio Bernardini (504056)Hanin I. Daas (21841853)Duaa W. Al‐Sadeq (21841856)Nadin Younes (4863280)Farah M. Shurrab (21841859)Parveen B. Nizamuddin (21841862)Fathima Humaira (21841865)Nader Al‐Dewik (14777014)Hadi M. Yassine (21841868)Laith J. Abu‐Raddad (21841871)Ahmed Ismail (2671822)Gheyath K. Nasrallah (21841874)Biological sciencesGeneticsBiomedical and clinical sciencesClinical sciencesImmunologyHealth sciencesEpidemiologyPublic healthantibodiesanti- S1-IgAanti- S-RBD IgGboosterCOVID-19immune responseneutralizing antibodyvaccination<h3>Background</h3><p dir="ltr">Priming with ChAdOx1 followed by heterologous boosting is considered in several countries. Nevertheless, analyses comparing the immunogenicity of heterologous booster to homologous primary vaccination regimens and natural infection are lacking. In this study, we aimed to conduct a comparative assessment of the immunogenicity between homologous primary vaccination regimens and heterologous prime‐boost vaccination using BNT162b2 or mRNA‐1273.</p><h3>Methods</h3><p dir="ltr">We matched vaccinated naïve (VN) individuals (<i>n</i> = 673) with partial vaccination (<i>n</i> = 64), primary vaccination (<i>n</i> = 590), and primary series plus mRNA vaccine heterologous booster (<i>n</i> = 19) with unvaccinated naturally infected (NI) individuals with a documented primary SARS‐CoV‐2 infection (<i>n</i> = 206). We measured the levels of neutralizing total antibodies (NTAbs), total antibodies (TAbs), anti‐S‐RBD IgG, and anti‐S1 IgA titers.</p><h3>Results</h3><p dir="ltr">Homologous primary vaccination with ChAdOx1 not only showed less potent NTAb, TAb, anti‐S‐RBD IgG, and anti‐S1 IgA immune responses compared to primary BNT162b2 or mRNA‐1273 vaccination regimens (<i>p</i> < 0.05) but also showed ~3‐fold less anti‐S1 IgA response compared to infection‐induced immunity (<i>p</i> < 0.001). Nevertheless, a heterologous booster led to an increase of ~12 times in the immune response when compared to two consecutive homologous ChAdOx1 immunizations. Furthermore, correlation analyses revealed that both anti‐S‐RBD IgG and anti‐S1 IgA significantly contributed to virus neutralization among NI individuals, particularly in symptomatic and pauci‐symptomatic individuals, whereas among VN individuals, anti‐S‐RBD IgG was the main contributor to virus neutralization.</p><h3>Conclusion</h3><p dir="ltr">The results emphasize the potential benefit of using heterologous mRNA boosters to increase antibody levels and neutralizing capacity particularly in patients who received primary vaccination with ChAdOx1.</p><h2>Other Information</h2><p dir="ltr">Published in: Influenza and Other Respiratory Viruses<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1111/irv.13290" target="_blank">https://dx.doi.org/10.1111/irv.13290</a></p>2024-05-06T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1111/irv.13290https://figshare.com/articles/journal_contribution/Follow_Up_and_Comparative_Assessment_of_SARS_CoV_2_IgA_IgG_Neutralizing_and_Total_Antibody_Responses_After_BNT162b2_or_mRNA_1273_Heterologous_Booster_Vaccination/29715341CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/297153412024-05-06T03:00:00Z |
| spellingShingle | Follow‐Up and Comparative Assessment of SARS‐CoV‐2 IgA, IgG, Neutralizing, and Total Antibody Responses After BNT162b2 or mRNA‐1273 Heterologous Booster Vaccination Salma Younes (6424865) Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Immunology Health sciences Epidemiology Public health antibodies anti- S1-IgA anti- S-RBD IgG booster COVID-19 immune response neutralizing antibody vaccination |
| status_str | publishedVersion |
| title | Follow‐Up and Comparative Assessment of SARS‐CoV‐2 IgA, IgG, Neutralizing, and Total Antibody Responses After BNT162b2 or mRNA‐1273 Heterologous Booster Vaccination |
| title_full | Follow‐Up and Comparative Assessment of SARS‐CoV‐2 IgA, IgG, Neutralizing, and Total Antibody Responses After BNT162b2 or mRNA‐1273 Heterologous Booster Vaccination |
| title_fullStr | Follow‐Up and Comparative Assessment of SARS‐CoV‐2 IgA, IgG, Neutralizing, and Total Antibody Responses After BNT162b2 or mRNA‐1273 Heterologous Booster Vaccination |
| title_full_unstemmed | Follow‐Up and Comparative Assessment of SARS‐CoV‐2 IgA, IgG, Neutralizing, and Total Antibody Responses After BNT162b2 or mRNA‐1273 Heterologous Booster Vaccination |
| title_short | Follow‐Up and Comparative Assessment of SARS‐CoV‐2 IgA, IgG, Neutralizing, and Total Antibody Responses After BNT162b2 or mRNA‐1273 Heterologous Booster Vaccination |
| title_sort | Follow‐Up and Comparative Assessment of SARS‐CoV‐2 IgA, IgG, Neutralizing, and Total Antibody Responses After BNT162b2 or mRNA‐1273 Heterologous Booster Vaccination |
| topic | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Immunology Health sciences Epidemiology Public health antibodies anti- S1-IgA anti- S-RBD IgG booster COVID-19 immune response neutralizing antibody vaccination |