Comparison of four intensive care scores in prediction of outcome after Veno-Arterial ECMO: A single-center retrospective study
<h3>Objective</h3><p dir="ltr">Assess the capability of APACHE-II (Acute Physiology and Chronic Health Evaluation II), SOFA (Sequential Organ Failure Assessment scores), Cardiac Surgery Score (CASUS), and SAVE (Survival After VA-ECMO) in predicting outcomes among a cohort...
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| مؤلفون آخرون: | , , , , , , , , , , , |
| منشور في: |
2024
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| _version_ | 1864513555490930688 |
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| author | Suraj Sudarsanan (20090727) |
| author2 | Praveen Sivadasan (20090730) Prem Chandra (9072038) Amr S Omar (20090733) Kathy Lynn Gaviola Atuel (20090736) Hafeez Ulla Lone (20090739) Hany O Ragab (20090742) Irshad Ehsan (20090745) Cornelia S Carr (20090748) Abdulrasheed Pattath (20090751) Abdulaziz Al khulaifi (20090754) Yasser Mahfouz Eltokhy Shouman (20090757) A-Wahid Mahmoud A.A. Al Mulla (20090760) |
| author2_role | author author author author author author author author author author author author |
| author_facet | Suraj Sudarsanan (20090727) Praveen Sivadasan (20090730) Prem Chandra (9072038) Amr S Omar (20090733) Kathy Lynn Gaviola Atuel (20090736) Hafeez Ulla Lone (20090739) Hany O Ragab (20090742) Irshad Ehsan (20090745) Cornelia S Carr (20090748) Abdulrasheed Pattath (20090751) Abdulaziz Al khulaifi (20090754) Yasser Mahfouz Eltokhy Shouman (20090757) A-Wahid Mahmoud A.A. Al Mulla (20090760) |
| author_role | author |
| dc.creator.none.fl_str_mv | Suraj Sudarsanan (20090727) Praveen Sivadasan (20090730) Prem Chandra (9072038) Amr S Omar (20090733) Kathy Lynn Gaviola Atuel (20090736) Hafeez Ulla Lone (20090739) Hany O Ragab (20090742) Irshad Ehsan (20090745) Cornelia S Carr (20090748) Abdulrasheed Pattath (20090751) Abdulaziz Al khulaifi (20090754) Yasser Mahfouz Eltokhy Shouman (20090757) A-Wahid Mahmoud A.A. Al Mulla (20090760) |
| dc.date.none.fl_str_mv | 2024-10-22T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1053/j.jvca.2024.10.027 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Comparison_of_four_intensive_care_scores_in_prediction_of_outcome_after_Veno-Arterial_ECMO_A_single-center_retrospective_study/27574416 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology VA-ECMO outcome prediction risk scoring in VA-ECMO patients in ICU mortality prediction post-VA ECMO |
| dc.title.none.fl_str_mv | Comparison of four intensive care scores in prediction of outcome after Veno-Arterial ECMO: A single-center retrospective study |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Objective</h3><p dir="ltr">Assess the capability of APACHE-II (Acute Physiology and Chronic Health Evaluation II), SOFA (Sequential Organ Failure Assessment scores), Cardiac Surgery Score (CASUS), and SAVE (Survival After VA-ECMO) in predicting outcomes among a cohort of patients undergoing Veno-Arterial ECMO (VA-ECMO).</p><h3>Design</h3><p dir="ltr">This is an observational retrospective study of 142 patients who were admitted to the Cardiothoracic Intensive Care Unit (CTICU) after undergoing VA-ECMO insertion.</p><h3>Setting</h3><p dir="ltr">CTICU of a tertiary care center.</p><h3>Participants</h3><p dir="ltr">All patients admitted to the CTICU for a minimum duration of 24 h, post-VA ECMO insertion, between the years 2015 and 2022.</p><h3>Interventions</h3><p dir="ltr">Review of electronic patient records.</p><h3>Measurements and Results</h3><p dir="ltr">Scores for APACHE-II, SOFA, and CASUS were calculated 24 h after intensive care units (ICU) admission. The SAVE score was computed from the last available patient details within 24 h of ECMO insertion. Relevant demographic, clinical, and laboratory data for the study was retrieved from electronic patient records. Pre-ECMO serum levels of lactates and creatinine were significantly associated with mortality. Lower ECMO flow rates at 4 h and 12 h post-ECMO cannulation were significantly correlated with survival to discharge. The development of arrhythmias, acute kidney injury (AKI), and the need for continuous renal replacement therapy (CRRT) while on ECMO were significantly associated with mortality. The APACHE-II, SOFA, and CASUS scores, calculated at 24 h of ICU admission, were significantly higher amongst non-survivors. Following risk score categorization using receiver operating characteristic (ROC) curve analysis, it was found that APACHE-II, SOFA, and CASUS scores calculated at 24 h post-ICU admission after ECMO insertion demonstrated moderate predictive ability for mortality, whereas the SAVE score failed to predict mortality. APACHE-II > 27 (AUC of 0.66), calculated 24 h post-ICU admission after ECMO insertion, showed the greatest predictive ability for mortality. Multivariate logistic regression analysis of the four scores showed that APACHE-II > 27 and SOFA > 14, calculated 24 h post-ICU admission after ECMO insertion, were independently significantly predictive of mortality.</p><h3>Conclusion</h3><p dir="ltr">The APACHE-II, SOFA, and CASUS, calculated at 24 h of ICU admission, were significantly higher among non-survivors compared to survivors. APACHE-II demonstrated the highest mortality predictive ability. APACHE-II scores of 27 or above, and SOFA scores of 14 or above, at 24 h of ICU admission after ECMO cannulation, can predict mortality and assist physicians in decision-making.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Cardiothoracic and Vascular Anesthesia<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1053/j.jvca.2024.10.027" target="_blank">https://dx.doi.org/10.1053/j.jvca.2024.10.027</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_4151581d9ed1df37878bef8bc57981e7 |
| identifier_str_mv | 10.1053/j.jvca.2024.10.027 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/27574416 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Comparison of four intensive care scores in prediction of outcome after Veno-Arterial ECMO: A single-center retrospective studySuraj Sudarsanan (20090727)Praveen Sivadasan (20090730)Prem Chandra (9072038)Amr S Omar (20090733)Kathy Lynn Gaviola Atuel (20090736)Hafeez Ulla Lone (20090739)Hany O Ragab (20090742)Irshad Ehsan (20090745)Cornelia S Carr (20090748)Abdulrasheed Pattath (20090751)Abdulaziz Al khulaifi (20090754)Yasser Mahfouz Eltokhy Shouman (20090757)A-Wahid Mahmoud A.A. Al Mulla (20090760)Biomedical and clinical sciencesCardiovascular medicine and haematologyVA-ECMO outcome predictionrisk scoring in VA-ECMO patients in ICUmortality prediction post-VA ECMO<h3>Objective</h3><p dir="ltr">Assess the capability of APACHE-II (Acute Physiology and Chronic Health Evaluation II), SOFA (Sequential Organ Failure Assessment scores), Cardiac Surgery Score (CASUS), and SAVE (Survival After VA-ECMO) in predicting outcomes among a cohort of patients undergoing Veno-Arterial ECMO (VA-ECMO).</p><h3>Design</h3><p dir="ltr">This is an observational retrospective study of 142 patients who were admitted to the Cardiothoracic Intensive Care Unit (CTICU) after undergoing VA-ECMO insertion.</p><h3>Setting</h3><p dir="ltr">CTICU of a tertiary care center.</p><h3>Participants</h3><p dir="ltr">All patients admitted to the CTICU for a minimum duration of 24 h, post-VA ECMO insertion, between the years 2015 and 2022.</p><h3>Interventions</h3><p dir="ltr">Review of electronic patient records.</p><h3>Measurements and Results</h3><p dir="ltr">Scores for APACHE-II, SOFA, and CASUS were calculated 24 h after intensive care units (ICU) admission. The SAVE score was computed from the last available patient details within 24 h of ECMO insertion. Relevant demographic, clinical, and laboratory data for the study was retrieved from electronic patient records. Pre-ECMO serum levels of lactates and creatinine were significantly associated with mortality. Lower ECMO flow rates at 4 h and 12 h post-ECMO cannulation were significantly correlated with survival to discharge. The development of arrhythmias, acute kidney injury (AKI), and the need for continuous renal replacement therapy (CRRT) while on ECMO were significantly associated with mortality. The APACHE-II, SOFA, and CASUS scores, calculated at 24 h of ICU admission, were significantly higher amongst non-survivors. Following risk score categorization using receiver operating characteristic (ROC) curve analysis, it was found that APACHE-II, SOFA, and CASUS scores calculated at 24 h post-ICU admission after ECMO insertion demonstrated moderate predictive ability for mortality, whereas the SAVE score failed to predict mortality. APACHE-II > 27 (AUC of 0.66), calculated 24 h post-ICU admission after ECMO insertion, showed the greatest predictive ability for mortality. Multivariate logistic regression analysis of the four scores showed that APACHE-II > 27 and SOFA > 14, calculated 24 h post-ICU admission after ECMO insertion, were independently significantly predictive of mortality.</p><h3>Conclusion</h3><p dir="ltr">The APACHE-II, SOFA, and CASUS, calculated at 24 h of ICU admission, were significantly higher among non-survivors compared to survivors. APACHE-II demonstrated the highest mortality predictive ability. APACHE-II scores of 27 or above, and SOFA scores of 14 or above, at 24 h of ICU admission after ECMO cannulation, can predict mortality and assist physicians in decision-making.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Cardiothoracic and Vascular Anesthesia<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1053/j.jvca.2024.10.027" target="_blank">https://dx.doi.org/10.1053/j.jvca.2024.10.027</a></p>2024-10-22T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1053/j.jvca.2024.10.027https://figshare.com/articles/journal_contribution/Comparison_of_four_intensive_care_scores_in_prediction_of_outcome_after_Veno-Arterial_ECMO_A_single-center_retrospective_study/27574416CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/275744162024-10-22T03:00:00Z |
| spellingShingle | Comparison of four intensive care scores in prediction of outcome after Veno-Arterial ECMO: A single-center retrospective study Suraj Sudarsanan (20090727) Biomedical and clinical sciences Cardiovascular medicine and haematology VA-ECMO outcome prediction risk scoring in VA-ECMO patients in ICU mortality prediction post-VA ECMO |
| status_str | publishedVersion |
| title | Comparison of four intensive care scores in prediction of outcome after Veno-Arterial ECMO: A single-center retrospective study |
| title_full | Comparison of four intensive care scores in prediction of outcome after Veno-Arterial ECMO: A single-center retrospective study |
| title_fullStr | Comparison of four intensive care scores in prediction of outcome after Veno-Arterial ECMO: A single-center retrospective study |
| title_full_unstemmed | Comparison of four intensive care scores in prediction of outcome after Veno-Arterial ECMO: A single-center retrospective study |
| title_short | Comparison of four intensive care scores in prediction of outcome after Veno-Arterial ECMO: A single-center retrospective study |
| title_sort | Comparison of four intensive care scores in prediction of outcome after Veno-Arterial ECMO: A single-center retrospective study |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology VA-ECMO outcome prediction risk scoring in VA-ECMO patients in ICU mortality prediction post-VA ECMO |