Salivary α-amylase activity is associated with cardiometabolic and inflammatory biomarkers in overweight/obese, non-diabetic Qatari women
<h3>Introduction</h3><p dir="ltr">Obesity, prevalent in approximately 80% of Qatar’s adult population, increases the risk of complications like type 2 diabetes and cardiovascular diseases. Predictive biomarkers are crucial for preventive strategies. Salivary α-amylase act...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , |
| منشور في: |
2024
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513510246973440 |
|---|---|
| author | Neyla S. Al Akl (15189997) |
| author2 | Olfa Khalifa (10914452) Mohammad Habibullah (12829454) Abdelilah Arredouani (10914455) |
| author2_role | author author author |
| author_facet | Neyla S. Al Akl (15189997) Olfa Khalifa (10914452) Mohammad Habibullah (12829454) Abdelilah Arredouani (10914455) |
| author_role | author |
| dc.creator.none.fl_str_mv | Neyla S. Al Akl (15189997) Olfa Khalifa (10914452) Mohammad Habibullah (12829454) Abdelilah Arredouani (10914455) |
| dc.date.none.fl_str_mv | 2024-03-18T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fendo.2024.1348853 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Salivary_-amylase_activity_is_associated_with_cardiometabolic_and_inflammatory_biomarkers_in_overweight_obese_non-diabetic_Qatari_women/26363266 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Medical biochemistry and metabolomics Nutrition and dietetics salivary α-amylase activity obesity cardiometabolic risk inflammation cardiovascular disease |
| dc.title.none.fl_str_mv | Salivary α-amylase activity is associated with cardiometabolic and inflammatory biomarkers in overweight/obese, non-diabetic Qatari women |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Introduction</h3><p dir="ltr">Obesity, prevalent in approximately 80% of Qatar’s adult population, increases the risk of complications like type 2 diabetes and cardiovascular diseases. Predictive biomarkers are crucial for preventive strategies. Salivary α-amylase activity (sAAa) inversely correlates with obesity and insulin resistance in adults and children. However, the connection between sAAa and cardiometabolic risk factors or chronic low-grade inflammation markers remains unclear. This study explores the association between serum sAAa and adiposity markers related to cardiovascular diseases, as well as markers indicative of chronic low-grade inflammation.</p><h3>Methods</h3><p dir="ltr">Serum samples and clinical data of 1500 adult, non-diabetic, Overweight/Obese participants were obtained from Qatar Biobank (QBB). We quantified sAAa and C reactive protein (CRP) levels with an autoanalyzer. Cytokines, adipokines, and adiponectin of a subset of 228 samples were quantified using a bead-based multiplex assay. The associations between the sAAa and the adiposity indices and low-grade inflammatory protein CRP and multiple cytokines were assessed using Pearson’s correlation and adjusted linear regression.</p><h3>Results</h3><p dir="ltr">The mean age of the participants was 36 ± 10 years for both sexes of which 76.6% are women. Our analysis revealed a significant linear association between sAAa and adiposity-associated biomarkers, including body mass index β -0.032 [95% CI -0.049 to -0.05], waist circumference β -0.05 [95% CI -0.09 to -0.02], hip circumference β -0.052 [95% CI -0.087 to -0.017], and HDL β 0.002 [95% CI 0.001 to 0.004], albeit only in women. Additionally, sAAa demonstrated a significant positive association with adiponectin β 0.007 [95% CI 0.001 to 0.01]while concurrently displaying significant negative associations with CRP β -0.02 [95% CI -0.044 to -0.0001], TNF-α β -0.105 [95% CI -0.207 to -0.004], IL-6 β [95% CI -0.39 -0.75 to -0.04], and ghrelin β -5.95 [95% CI -11.71 to -0.20], specifically within the female population.</p><h3>Conclusion</h3><p dir="ltr">Our findings delineate significant associations between sAAa and markers indicative of cardiovascular disease risk and inflammation among overweight/obese adult Qatari females. Subsequent investigations are warranted to elucidate the nuances of these gender-specific associations comprehensively.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Endocrinology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fendo.2024.1348853" target="_blank">https://dx.doi.org/10.3389/fendo.2024.1348853</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_415578b28f54c6cfcc9609301845fb8f |
| identifier_str_mv | 10.3389/fendo.2024.1348853 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26363266 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Salivary α-amylase activity is associated with cardiometabolic and inflammatory biomarkers in overweight/obese, non-diabetic Qatari womenNeyla S. Al Akl (15189997)Olfa Khalifa (10914452)Mohammad Habibullah (12829454)Abdelilah Arredouani (10914455)Biomedical and clinical sciencesCardiovascular medicine and haematologyMedical biochemistry and metabolomicsNutrition and dieteticssalivary α-amylase activityobesitycardiometabolic riskinflammationcardiovascular disease<h3>Introduction</h3><p dir="ltr">Obesity, prevalent in approximately 80% of Qatar’s adult population, increases the risk of complications like type 2 diabetes and cardiovascular diseases. Predictive biomarkers are crucial for preventive strategies. Salivary α-amylase activity (sAAa) inversely correlates with obesity and insulin resistance in adults and children. However, the connection between sAAa and cardiometabolic risk factors or chronic low-grade inflammation markers remains unclear. This study explores the association between serum sAAa and adiposity markers related to cardiovascular diseases, as well as markers indicative of chronic low-grade inflammation.</p><h3>Methods</h3><p dir="ltr">Serum samples and clinical data of 1500 adult, non-diabetic, Overweight/Obese participants were obtained from Qatar Biobank (QBB). We quantified sAAa and C reactive protein (CRP) levels with an autoanalyzer. Cytokines, adipokines, and adiponectin of a subset of 228 samples were quantified using a bead-based multiplex assay. The associations between the sAAa and the adiposity indices and low-grade inflammatory protein CRP and multiple cytokines were assessed using Pearson’s correlation and adjusted linear regression.</p><h3>Results</h3><p dir="ltr">The mean age of the participants was 36 ± 10 years for both sexes of which 76.6% are women. Our analysis revealed a significant linear association between sAAa and adiposity-associated biomarkers, including body mass index β -0.032 [95% CI -0.049 to -0.05], waist circumference β -0.05 [95% CI -0.09 to -0.02], hip circumference β -0.052 [95% CI -0.087 to -0.017], and HDL β 0.002 [95% CI 0.001 to 0.004], albeit only in women. Additionally, sAAa demonstrated a significant positive association with adiponectin β 0.007 [95% CI 0.001 to 0.01]while concurrently displaying significant negative associations with CRP β -0.02 [95% CI -0.044 to -0.0001], TNF-α β -0.105 [95% CI -0.207 to -0.004], IL-6 β [95% CI -0.39 -0.75 to -0.04], and ghrelin β -5.95 [95% CI -11.71 to -0.20], specifically within the female population.</p><h3>Conclusion</h3><p dir="ltr">Our findings delineate significant associations between sAAa and markers indicative of cardiovascular disease risk and inflammation among overweight/obese adult Qatari females. Subsequent investigations are warranted to elucidate the nuances of these gender-specific associations comprehensively.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Endocrinology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fendo.2024.1348853" target="_blank">https://dx.doi.org/10.3389/fendo.2024.1348853</a></p>2024-03-18T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fendo.2024.1348853https://figshare.com/articles/journal_contribution/Salivary_-amylase_activity_is_associated_with_cardiometabolic_and_inflammatory_biomarkers_in_overweight_obese_non-diabetic_Qatari_women/26363266CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/263632662024-03-18T09:00:00Z |
| spellingShingle | Salivary α-amylase activity is associated with cardiometabolic and inflammatory biomarkers in overweight/obese, non-diabetic Qatari women Neyla S. Al Akl (15189997) Biomedical and clinical sciences Cardiovascular medicine and haematology Medical biochemistry and metabolomics Nutrition and dietetics salivary α-amylase activity obesity cardiometabolic risk inflammation cardiovascular disease |
| status_str | publishedVersion |
| title | Salivary α-amylase activity is associated with cardiometabolic and inflammatory biomarkers in overweight/obese, non-diabetic Qatari women |
| title_full | Salivary α-amylase activity is associated with cardiometabolic and inflammatory biomarkers in overweight/obese, non-diabetic Qatari women |
| title_fullStr | Salivary α-amylase activity is associated with cardiometabolic and inflammatory biomarkers in overweight/obese, non-diabetic Qatari women |
| title_full_unstemmed | Salivary α-amylase activity is associated with cardiometabolic and inflammatory biomarkers in overweight/obese, non-diabetic Qatari women |
| title_short | Salivary α-amylase activity is associated with cardiometabolic and inflammatory biomarkers in overweight/obese, non-diabetic Qatari women |
| title_sort | Salivary α-amylase activity is associated with cardiometabolic and inflammatory biomarkers in overweight/obese, non-diabetic Qatari women |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Medical biochemistry and metabolomics Nutrition and dietetics salivary α-amylase activity obesity cardiometabolic risk inflammation cardiovascular disease |