The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms
<p dir="ltr">Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. While the incidence and mortality of CRC have decreased overall due to better screening, rates in adults under 50 have risen. CRC can manifest as inherited syndromes (10%), familia...
محفوظ في:
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| مؤلفون آخرون: | , , , |
| منشور في: |
2025
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513538076180480 |
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| author | Farah Karam (22330564) |
| author2 | Yara El Deghel (22330567) Rabah Iratni (381416) Ali H. Dakroub (22303819) Ali H. Eid (5461829) |
| author2_role | author author author author |
| author_facet | Farah Karam (22330564) Yara El Deghel (22330567) Rabah Iratni (381416) Ali H. Dakroub (22303819) Ali H. Eid (5461829) |
| author_role | author |
| dc.creator.none.fl_str_mv | Farah Karam (22330564) Yara El Deghel (22330567) Rabah Iratni (381416) Ali H. Dakroub (22303819) Ali H. Eid (5461829) |
| dc.date.none.fl_str_mv | 2025-02-13T09:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s12013-025-01683-9 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_Gut_Microbiome_and_Colorectal_Cancer_An_Integrative_Review_of_the_Underlying_Mechanisms/30234052 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Immunology Oncology and carcinogenesis Colorectal cancer Microbiota Gut Tumor Bacteria Probiotics Dysbiosis |
| dc.title.none.fl_str_mv | The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. While the incidence and mortality of CRC have decreased overall due to better screening, rates in adults under 50 have risen. CRC can manifest as inherited syndromes (10%), familial clustering (20%), or sporadic forms (70%). The gut microbiota, comprising mainly firmicutes and bacteroidetes, play a key role in CRC development and prevention. Indeed, CRC progression is influenced by the dynamic interaction between the gut microbiota, the intestinal barrier, the immune system, and the production of short-chain fatty acids. Not surprisingly, imbalance in the gut microbiota, termed dysbiosis, has been linked to CRC due to ensuing chronic inflammation, DNA damage, and oxidative stress. This may explain the notion that probiotics and fecal microbiota transplantation offer potential strategies for CRC prevention and treatment by restoring microbial balance and enhancing anti-cancer immune responses. This review appraises the roles of gut microbiota in promoting or preventing CRC. It also discusses the mechanistic interplay between microbiota composition, the intestinal barrier, and the immune system, with the hope of developing potential therapeutic strategies.</p><h2>Other Information</h2><p dir="ltr">Published in: Cell Biochemistry and Biophysics<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s12013-025-01683-9" target="_blank">https://dx.doi.org/10.1007/s12013-025-01683-9</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_4155bd1ee2ae211c0bee6009b25ed80d |
| identifier_str_mv | 10.1007/s12013-025-01683-9 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/30234052 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying MechanismsFarah Karam (22330564)Yara El Deghel (22330567)Rabah Iratni (381416)Ali H. Dakroub (22303819)Ali H. Eid (5461829)Biomedical and clinical sciencesClinical sciencesImmunologyOncology and carcinogenesisColorectal cancerMicrobiotaGutTumorBacteriaProbioticsDysbiosis<p dir="ltr">Colorectal cancer (CRC) is the second leading cause of cancer-related mortality worldwide. While the incidence and mortality of CRC have decreased overall due to better screening, rates in adults under 50 have risen. CRC can manifest as inherited syndromes (10%), familial clustering (20%), or sporadic forms (70%). The gut microbiota, comprising mainly firmicutes and bacteroidetes, play a key role in CRC development and prevention. Indeed, CRC progression is influenced by the dynamic interaction between the gut microbiota, the intestinal barrier, the immune system, and the production of short-chain fatty acids. Not surprisingly, imbalance in the gut microbiota, termed dysbiosis, has been linked to CRC due to ensuing chronic inflammation, DNA damage, and oxidative stress. This may explain the notion that probiotics and fecal microbiota transplantation offer potential strategies for CRC prevention and treatment by restoring microbial balance and enhancing anti-cancer immune responses. This review appraises the roles of gut microbiota in promoting or preventing CRC. It also discusses the mechanistic interplay between microbiota composition, the intestinal barrier, and the immune system, with the hope of developing potential therapeutic strategies.</p><h2>Other Information</h2><p dir="ltr">Published in: Cell Biochemistry and Biophysics<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s12013-025-01683-9" target="_blank">https://dx.doi.org/10.1007/s12013-025-01683-9</a></p>2025-02-13T09:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s12013-025-01683-9https://figshare.com/articles/journal_contribution/The_Gut_Microbiome_and_Colorectal_Cancer_An_Integrative_Review_of_the_Underlying_Mechanisms/30234052CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/302340522025-02-13T09:00:00Z |
| spellingShingle | The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms Farah Karam (22330564) Biomedical and clinical sciences Clinical sciences Immunology Oncology and carcinogenesis Colorectal cancer Microbiota Gut Tumor Bacteria Probiotics Dysbiosis |
| status_str | publishedVersion |
| title | The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms |
| title_full | The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms |
| title_fullStr | The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms |
| title_full_unstemmed | The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms |
| title_short | The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms |
| title_sort | The Gut Microbiome and Colorectal Cancer: An Integrative Review of the Underlying Mechanisms |
| topic | Biomedical and clinical sciences Clinical sciences Immunology Oncology and carcinogenesis Colorectal cancer Microbiota Gut Tumor Bacteria Probiotics Dysbiosis |