Pancreatic β-cell heterogeneity in adult human islets and stem cell-derived islets
<p dir="ltr">Recent studies reported that pancreatic β-cells are heterogeneous in terms of their transcriptional profiles and their abilities for insulin secretion. Sub-populations of pancreatic β-cells have been identified based on the functionality and expression of specific surfac...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| منشور في: |
2023
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513530980466688 |
|---|---|
| author | Noura Aldous (15429873) |
| author2 | Abu Saleh Md Moin (6189512) Essam M. Abdelalim (5768072) |
| author2_role | author author |
| author_facet | Noura Aldous (15429873) Abu Saleh Md Moin (6189512) Essam M. Abdelalim (5768072) |
| author_role | author |
| dc.creator.none.fl_str_mv | Noura Aldous (15429873) Abu Saleh Md Moin (6189512) Essam M. Abdelalim (5768072) |
| dc.date.none.fl_str_mv | 2023-06-03T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s00018-023-04815-7 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Pancreatic_-cell_heterogeneity_in_adult_human_islets_and_stem_cell-derived_islets/24967086 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Medical biochemistry and metabolomics Medical biotechnology Diabetes β-cell subpopulations Cell–cell contact Insulin secretion Cell therapy |
| dc.title.none.fl_str_mv | Pancreatic β-cell heterogeneity in adult human islets and stem cell-derived islets |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Recent studies reported that pancreatic β-cells are heterogeneous in terms of their transcriptional profiles and their abilities for insulin secretion. Sub-populations of pancreatic β-cells have been identified based on the functionality and expression of specific surface markers. Under diabetes condition, β-cell identity is altered leading to different β-cell sub-populations. Furthermore, cell–cell contact between β-cells and other endocrine cells within the islet play an important role in regulating insulin secretion. This highlights the significance of generating a cell product derived from stem cells containing β-cells along with other major islet cells for treating patients with diabetes, instead of transplanting a purified population of β-cells. Another key question is how close in terms of heterogeneity are the islet cells derived from stem cells? In this review, we summarize the heterogeneity in islet cells of the adult pancreas and those generated from stem cells. In addition, we highlight the significance of this heterogeneity in health and disease conditions and how this can be used to design a stem cell-derived product for diabetes cell therapy.</p><h2>Other Information</h2><p dir="ltr">Published in: Cellular and Molecular Life Sciences<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s00018-023-04815-7" target="_blank">https://dx.doi.org/10.1007/s00018-023-04815-7</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_4176df53d938ecead38c0d224a15797c |
| identifier_str_mv | 10.1007/s00018-023-04815-7 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24967086 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Pancreatic β-cell heterogeneity in adult human islets and stem cell-derived isletsNoura Aldous (15429873)Abu Saleh Md Moin (6189512)Essam M. Abdelalim (5768072)Biological sciencesBiochemistry and cell biologyBiomedical and clinical sciencesMedical biochemistry and metabolomicsMedical biotechnologyDiabetesβ-cell subpopulationsCell–cell contactInsulin secretionCell therapy<p dir="ltr">Recent studies reported that pancreatic β-cells are heterogeneous in terms of their transcriptional profiles and their abilities for insulin secretion. Sub-populations of pancreatic β-cells have been identified based on the functionality and expression of specific surface markers. Under diabetes condition, β-cell identity is altered leading to different β-cell sub-populations. Furthermore, cell–cell contact between β-cells and other endocrine cells within the islet play an important role in regulating insulin secretion. This highlights the significance of generating a cell product derived from stem cells containing β-cells along with other major islet cells for treating patients with diabetes, instead of transplanting a purified population of β-cells. Another key question is how close in terms of heterogeneity are the islet cells derived from stem cells? In this review, we summarize the heterogeneity in islet cells of the adult pancreas and those generated from stem cells. In addition, we highlight the significance of this heterogeneity in health and disease conditions and how this can be used to design a stem cell-derived product for diabetes cell therapy.</p><h2>Other Information</h2><p dir="ltr">Published in: Cellular and Molecular Life Sciences<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s00018-023-04815-7" target="_blank">https://dx.doi.org/10.1007/s00018-023-04815-7</a></p>2023-06-03T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s00018-023-04815-7https://figshare.com/articles/journal_contribution/Pancreatic_-cell_heterogeneity_in_adult_human_islets_and_stem_cell-derived_islets/24967086CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/249670862023-06-03T03:00:00Z |
| spellingShingle | Pancreatic β-cell heterogeneity in adult human islets and stem cell-derived islets Noura Aldous (15429873) Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Medical biochemistry and metabolomics Medical biotechnology Diabetes β-cell subpopulations Cell–cell contact Insulin secretion Cell therapy |
| status_str | publishedVersion |
| title | Pancreatic β-cell heterogeneity in adult human islets and stem cell-derived islets |
| title_full | Pancreatic β-cell heterogeneity in adult human islets and stem cell-derived islets |
| title_fullStr | Pancreatic β-cell heterogeneity in adult human islets and stem cell-derived islets |
| title_full_unstemmed | Pancreatic β-cell heterogeneity in adult human islets and stem cell-derived islets |
| title_short | Pancreatic β-cell heterogeneity in adult human islets and stem cell-derived islets |
| title_sort | Pancreatic β-cell heterogeneity in adult human islets and stem cell-derived islets |
| topic | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Medical biochemistry and metabolomics Medical biotechnology Diabetes β-cell subpopulations Cell–cell contact Insulin secretion Cell therapy |