Molecular epidemiology, genetic diversity, and vaccine availability of viral acute gastroenteritis in the middle East and North Africa (MENA) region
<p>Acute gastroenteritis is the cause of considerable mortality and morbidity worldwide, particularly among children under five years in underdeveloped countries. Most acute gastroenteritis (AGE) cases are attributed to viral etiologies, including rotavirus, norovirus, adenovirus, astrovirus,...
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2022
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| _version_ | 1864513528917917696 |
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| author | Israa Elbashir (17863814) |
| author2 | Noor F. Aldoos (17863817) Shilu Mathew (625826) Asmaa A. Al Thani (10494576) Mohamed M. Emara (9913215) Hadi M. Yassine (4675846) |
| author2_role | author author author author author |
| author_facet | Israa Elbashir (17863814) Noor F. Aldoos (17863817) Shilu Mathew (625826) Asmaa A. Al Thani (10494576) Mohamed M. Emara (9913215) Hadi M. Yassine (4675846) |
| author_role | author |
| dc.creator.none.fl_str_mv | Israa Elbashir (17863814) Noor F. Aldoos (17863817) Shilu Mathew (625826) Asmaa A. Al Thani (10494576) Mohamed M. Emara (9913215) Hadi M. Yassine (4675846) |
| dc.date.none.fl_str_mv | 2022-11-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.jiph.2022.09.001 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Molecular_epidemiology_genetic_diversity_and_vaccine_availability_of_viral_acute_gastroenteritis_in_the_middle_East_and_North_Africa_MENA_region/25101881 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Health sciences Public health Acute gastroenteritis Rotavirus Norovirus Adenovirus Astrovirus Sapovirus Phylogenetic analysis Rotavirus vaccine Middle East And North Africa |
| dc.title.none.fl_str_mv | Molecular epidemiology, genetic diversity, and vaccine availability of viral acute gastroenteritis in the middle East and North Africa (MENA) region |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>Acute gastroenteritis is the cause of considerable mortality and morbidity worldwide, particularly among children under five years in underdeveloped countries. Most acute gastroenteritis (AGE) cases are attributed to viral etiologies, including rotavirus, norovirus, adenovirus, astrovirus, and sapovirus. This paper aimed to determine the prevalence rate of different viral etiologies of AGE in the Middle East and North Africa (MENA) region. Moreover, this paper explored rotavirus phylogenetic relatedness, compared VP7 and VP4 antigenic regions of rotavirus with vaccine strains, and explored the availability of vaccines in the MENA region. The literature search identified 160 studies from 18 countries from 1980 to 2019. The overall prevalence of rotavirus, norovirus, adenovirus, astrovirus, and sapovirus were 29.8 %, 13.9 %, 6.3 %, 3.5 %, and 3.2 % of tested samples, respectively. The most common rotavirus genotype combinations in the MENA region were G1P[8], G9P[9], and G2P[4], whereas GII.4 was the predominant norovirus genotype all of which were reported in almost all the studies with genotyping data. The comparison of VP7 and VP4 between circulating rotavirus in the MENA region and vaccine strains has revealed discrete divergent regions, including the neutralizing epitopes. Rotavirus vaccine was introduced to most of the countries of the MENA region; however, only a few studies have assessed the effectiveness of vaccine introduction. This paper provides a comprehensive update on the prevalence of the different viral agents of AGE in the MENA region.</p><h2>Other Information</h2> <p> Published in: Journal of Infection and Public Health<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jiph.2022.09.001" target="_blank">https://dx.doi.org/10.1016/j.jiph.2022.09.001</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_420bcd987593f5026b67e174ba7c1815 |
| identifier_str_mv | 10.1016/j.jiph.2022.09.001 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25101881 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Molecular epidemiology, genetic diversity, and vaccine availability of viral acute gastroenteritis in the middle East and North Africa (MENA) regionIsraa Elbashir (17863814)Noor F. Aldoos (17863817)Shilu Mathew (625826)Asmaa A. Al Thani (10494576)Mohamed M. Emara (9913215)Hadi M. Yassine (4675846)Biomedical and clinical sciencesClinical sciencesHealth sciencesPublic healthAcute gastroenteritisRotavirusNorovirusAdenovirusAstrovirusSapovirusPhylogenetic analysisRotavirus vaccineMiddle EastAnd North Africa<p>Acute gastroenteritis is the cause of considerable mortality and morbidity worldwide, particularly among children under five years in underdeveloped countries. Most acute gastroenteritis (AGE) cases are attributed to viral etiologies, including rotavirus, norovirus, adenovirus, astrovirus, and sapovirus. This paper aimed to determine the prevalence rate of different viral etiologies of AGE in the Middle East and North Africa (MENA) region. Moreover, this paper explored rotavirus phylogenetic relatedness, compared VP7 and VP4 antigenic regions of rotavirus with vaccine strains, and explored the availability of vaccines in the MENA region. The literature search identified 160 studies from 18 countries from 1980 to 2019. The overall prevalence of rotavirus, norovirus, adenovirus, astrovirus, and sapovirus were 29.8 %, 13.9 %, 6.3 %, 3.5 %, and 3.2 % of tested samples, respectively. The most common rotavirus genotype combinations in the MENA region were G1P[8], G9P[9], and G2P[4], whereas GII.4 was the predominant norovirus genotype all of which were reported in almost all the studies with genotyping data. The comparison of VP7 and VP4 between circulating rotavirus in the MENA region and vaccine strains has revealed discrete divergent regions, including the neutralizing epitopes. Rotavirus vaccine was introduced to most of the countries of the MENA region; however, only a few studies have assessed the effectiveness of vaccine introduction. This paper provides a comprehensive update on the prevalence of the different viral agents of AGE in the MENA region.</p><h2>Other Information</h2> <p> Published in: Journal of Infection and Public Health<br> License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.jiph.2022.09.001" target="_blank">https://dx.doi.org/10.1016/j.jiph.2022.09.001</a></p>2022-11-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.jiph.2022.09.001https://figshare.com/articles/journal_contribution/Molecular_epidemiology_genetic_diversity_and_vaccine_availability_of_viral_acute_gastroenteritis_in_the_middle_East_and_North_Africa_MENA_region/25101881CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/251018812022-11-01T00:00:00Z |
| spellingShingle | Molecular epidemiology, genetic diversity, and vaccine availability of viral acute gastroenteritis in the middle East and North Africa (MENA) region Israa Elbashir (17863814) Biomedical and clinical sciences Clinical sciences Health sciences Public health Acute gastroenteritis Rotavirus Norovirus Adenovirus Astrovirus Sapovirus Phylogenetic analysis Rotavirus vaccine Middle East And North Africa |
| status_str | publishedVersion |
| title | Molecular epidemiology, genetic diversity, and vaccine availability of viral acute gastroenteritis in the middle East and North Africa (MENA) region |
| title_full | Molecular epidemiology, genetic diversity, and vaccine availability of viral acute gastroenteritis in the middle East and North Africa (MENA) region |
| title_fullStr | Molecular epidemiology, genetic diversity, and vaccine availability of viral acute gastroenteritis in the middle East and North Africa (MENA) region |
| title_full_unstemmed | Molecular epidemiology, genetic diversity, and vaccine availability of viral acute gastroenteritis in the middle East and North Africa (MENA) region |
| title_short | Molecular epidemiology, genetic diversity, and vaccine availability of viral acute gastroenteritis in the middle East and North Africa (MENA) region |
| title_sort | Molecular epidemiology, genetic diversity, and vaccine availability of viral acute gastroenteritis in the middle East and North Africa (MENA) region |
| topic | Biomedical and clinical sciences Clinical sciences Health sciences Public health Acute gastroenteritis Rotavirus Norovirus Adenovirus Astrovirus Sapovirus Phylogenetic analysis Rotavirus vaccine Middle East And North Africa |