Proteomic Profiling of Small-Cell Lung Cancer: A Systematic Review
<div><p>The accurate diagnosis of small-cell lung cancer (SCLC) is crucial, as treatment strategies differ from those of other lung cancers. This systematic review aims to identify proteins differentially expressed in SCLC compared to normal lung tissue, evaluating their potential utilit...
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2023
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| _version_ | 1864513526435938304 |
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| author | Amgad Mohamed Elshoeibi (17430963) |
| author2 | Basel Elsayed (14614273) Muhammad Zain Kaleem (18021955) Mohamed Ragab Elhadary (18021958) Mohannad Natheef Abu-Haweeleh (18021961) Yunes Haithm (18021964) Hubert Krzyslak (18021967) Semir Vranic (3353012) Shona Pedersen (2792278) |
| author2_role | author author author author author author author author |
| author_facet | Amgad Mohamed Elshoeibi (17430963) Basel Elsayed (14614273) Muhammad Zain Kaleem (18021955) Mohamed Ragab Elhadary (18021958) Mohannad Natheef Abu-Haweeleh (18021961) Yunes Haithm (18021964) Hubert Krzyslak (18021967) Semir Vranic (3353012) Shona Pedersen (2792278) |
| author_role | author |
| dc.creator.none.fl_str_mv | Amgad Mohamed Elshoeibi (17430963) Basel Elsayed (14614273) Muhammad Zain Kaleem (18021955) Mohamed Ragab Elhadary (18021958) Mohannad Natheef Abu-Haweeleh (18021961) Yunes Haithm (18021964) Hubert Krzyslak (18021967) Semir Vranic (3353012) Shona Pedersen (2792278) |
| dc.date.none.fl_str_mv | 2023-10-16T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/cancers15205005 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Proteomic_Profiling_of_Small-Cell_Lung_Cancer_A_Systematic_Review/25285186 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis small-cell lung cancer large cell neuroendocrine carcinoma proteomics diagnostics and prognostic biomarkers neuroendocrine tumors |
| dc.title.none.fl_str_mv | Proteomic Profiling of Small-Cell Lung Cancer: A Systematic Review |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>The accurate diagnosis of small-cell lung cancer (SCLC) is crucial, as treatment strategies differ from those of other lung cancers. This systematic review aims to identify proteins differentially expressed in SCLC compared to normal lung tissue, evaluating their potential utility in diagnosing and prognosing the disease. Additionally, the study identifies proteins differentially expressed between SCLC and large cell neuroendocrine carcinoma (LCNEC), aiming to discover biomarkers distinguishing between these two subtypes of neuroendocrine lung cancers. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive search was conducted across PubMed/MEDLINE, Scopus, Embase, and Web of Science databases. Studies reporting proteomics information and confirming SCLC and/or LCNEC through histopathological and/or cytopathological examination were included, while review articles, non-original articles, and studies based on animal samples or cell lines were excluded. The initial search yielded 1705 articles, and after deduplication and screening, 16 articles were deemed eligible. These studies revealed 117 unique proteins significantly differentially expressed in SCLC compared to normal lung tissue, along with 37 unique proteins differentially expressed between SCLC and LCNEC. In conclusion, this review highlights the potential of proteomics technology in identifying novel biomarkers for diagnosing SCLC, predicting its prognosis, and distinguishing it from LCNEC.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Cancers<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cancers15205005" target="_blank">https://dx.doi.org/10.3390/cancers15205005</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_421f57f38624d33ef1308baaf38deb19 |
| identifier_str_mv | 10.3390/cancers15205005 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25285186 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Proteomic Profiling of Small-Cell Lung Cancer: A Systematic ReviewAmgad Mohamed Elshoeibi (17430963)Basel Elsayed (14614273)Muhammad Zain Kaleem (18021955)Mohamed Ragab Elhadary (18021958)Mohannad Natheef Abu-Haweeleh (18021961)Yunes Haithm (18021964)Hubert Krzyslak (18021967)Semir Vranic (3353012)Shona Pedersen (2792278)Biomedical and clinical sciencesOncology and carcinogenesissmall-cell lung cancerlarge cell neuroendocrine carcinomaproteomicsdiagnostics and prognostic biomarkersneuroendocrine tumors<div><p>The accurate diagnosis of small-cell lung cancer (SCLC) is crucial, as treatment strategies differ from those of other lung cancers. This systematic review aims to identify proteins differentially expressed in SCLC compared to normal lung tissue, evaluating their potential utility in diagnosing and prognosing the disease. Additionally, the study identifies proteins differentially expressed between SCLC and large cell neuroendocrine carcinoma (LCNEC), aiming to discover biomarkers distinguishing between these two subtypes of neuroendocrine lung cancers. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a comprehensive search was conducted across PubMed/MEDLINE, Scopus, Embase, and Web of Science databases. Studies reporting proteomics information and confirming SCLC and/or LCNEC through histopathological and/or cytopathological examination were included, while review articles, non-original articles, and studies based on animal samples or cell lines were excluded. The initial search yielded 1705 articles, and after deduplication and screening, 16 articles were deemed eligible. These studies revealed 117 unique proteins significantly differentially expressed in SCLC compared to normal lung tissue, along with 37 unique proteins differentially expressed between SCLC and LCNEC. In conclusion, this review highlights the potential of proteomics technology in identifying novel biomarkers for diagnosing SCLC, predicting its prognosis, and distinguishing it from LCNEC.</p><p> </p></div><h2>Other Information</h2> <p> Published in: Cancers<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/cancers15205005" target="_blank">https://dx.doi.org/10.3390/cancers15205005</a></p>2023-10-16T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/cancers15205005https://figshare.com/articles/journal_contribution/Proteomic_Profiling_of_Small-Cell_Lung_Cancer_A_Systematic_Review/25285186CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/252851862023-10-16T03:00:00Z |
| spellingShingle | Proteomic Profiling of Small-Cell Lung Cancer: A Systematic Review Amgad Mohamed Elshoeibi (17430963) Biomedical and clinical sciences Oncology and carcinogenesis small-cell lung cancer large cell neuroendocrine carcinoma proteomics diagnostics and prognostic biomarkers neuroendocrine tumors |
| status_str | publishedVersion |
| title | Proteomic Profiling of Small-Cell Lung Cancer: A Systematic Review |
| title_full | Proteomic Profiling of Small-Cell Lung Cancer: A Systematic Review |
| title_fullStr | Proteomic Profiling of Small-Cell Lung Cancer: A Systematic Review |
| title_full_unstemmed | Proteomic Profiling of Small-Cell Lung Cancer: A Systematic Review |
| title_short | Proteomic Profiling of Small-Cell Lung Cancer: A Systematic Review |
| title_sort | Proteomic Profiling of Small-Cell Lung Cancer: A Systematic Review |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis small-cell lung cancer large cell neuroendocrine carcinoma proteomics diagnostics and prognostic biomarkers neuroendocrine tumors |