The triglyceride glucose-waist-to-height ratio outperforms obesity and other triglyceride-related parameters in detecting prediabetes in normal-weight Qatari adults: A cross-sectional study
<h3>Introduction </h3><p dir="ltr">The triglyceride-glucose (TyG)-driven indices, incorporating obesity indices, have been proposed as reliable markers of insulin resistance and related comorbidities such as diabetes. This study evaluated the effectiveness of these indice...
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| مؤلفون آخرون: | , , |
| منشور في: |
2023
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| _version_ | 1864513508070129664 |
|---|---|
| author | Neyla S. Al Akl (15189997) |
| author2 | Elias N. Haoudi (15190000) Halima Bensmail (10400) Abdelilah Arredouani (10914455) |
| author2_role | author author author |
| author_facet | Neyla S. Al Akl (15189997) Elias N. Haoudi (15190000) Halima Bensmail (10400) Abdelilah Arredouani (10914455) |
| author_role | author |
| dc.creator.none.fl_str_mv | Neyla S. Al Akl (15189997) Elias N. Haoudi (15190000) Halima Bensmail (10400) Abdelilah Arredouani (10914455) |
| dc.date.none.fl_str_mv | 2023-04-06T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fpubh.2023.1086771 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/The_triglyceride_glucose-waist-to-height_ratio_outperforms_obesity_and_other_triglyceride-related_parameters_in_detecting_prediabetes_in_normal-weight_Qatari_adults_A_cross-sectional_study/26661577 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical biochemistry and metabolomics Nutrition and dietetics Health sciences Epidemiology Public health prediabetes diabetes triglyceride-glucose-related waist-to-height ratio obesity normal-weight Qatar |
| dc.title.none.fl_str_mv | The triglyceride glucose-waist-to-height ratio outperforms obesity and other triglyceride-related parameters in detecting prediabetes in normal-weight Qatari adults: A cross-sectional study |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Introduction </h3><p dir="ltr">The triglyceride-glucose (TyG)-driven indices, incorporating obesity indices, have been proposed as reliable markers of insulin resistance and related comorbidities such as diabetes. This study evaluated the effectiveness of these indices in detecting prediabetes in normal-weight individuals from a Middle Eastern population. </p><h3>Methods </h3><p dir="ltr">Using the data of 5,996 adult Qatari participants from the Qatar Biobank cohort, we employed adjusted logistic regression to assess the ability of various obesity and triglyceride-related indices to detect prediabetes in normal-weight (18.5 ≤ BMI <25 kg/m<sup>2</sup>) adults (≥18 years). </p><h3>Results </h3><p dir="ltr">Of the normal-weight adults, 13.62% had prediabetes. TyG-waist-to-height ratio (TyG-WHTR) was significantly associated with prediabetes among normal-weight men [OR per 1-SD 2.68; 95% CI (1.67–4.32)] and women [OR per 1-SD 2.82; 95% CI (1.61–4.94)]. Compared with other indices, TyG-WHTR had the highest area under the curve (AUC) value for prediabetes in men [AUC: 0.76, 95% CI (0.70–0.81)] and women [AUC: 0.73, 95% CI (0.66–0.80)], and performed significantly higher than other indices (p < 0.05) in detecting prediabetes in men. Tyg-WHTR shared similar diagnostic values as fasting plasma glucose (FPG). </p><h3>Discussion </h3><p dir="ltr">Our findings suggest that the TyG-WHTR index could be a better indicator of prediabetes for general clinical usage in normal weight Qatari adult men than other obesity and TyG-related indices. TyG-WHTR can help identify a person’s risk for developing prediabetes in both men and women when combined with FPG results.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Public Health<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fpubh.2023.1086771" target="_blank">https://dx.doi.org/10.3389/fpubh.2023.1086771</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_433305848563cf3b69ce5c33f7971c85 |
| identifier_str_mv | 10.3389/fpubh.2023.1086771 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26661577 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | The triglyceride glucose-waist-to-height ratio outperforms obesity and other triglyceride-related parameters in detecting prediabetes in normal-weight Qatari adults: A cross-sectional studyNeyla S. Al Akl (15189997)Elias N. Haoudi (15190000)Halima Bensmail (10400)Abdelilah Arredouani (10914455)Biomedical and clinical sciencesMedical biochemistry and metabolomicsNutrition and dieteticsHealth sciencesEpidemiologyPublic healthprediabetesdiabetestriglyceride-glucose-related waist-to-height ratioobesitynormal-weightQatar<h3>Introduction </h3><p dir="ltr">The triglyceride-glucose (TyG)-driven indices, incorporating obesity indices, have been proposed as reliable markers of insulin resistance and related comorbidities such as diabetes. This study evaluated the effectiveness of these indices in detecting prediabetes in normal-weight individuals from a Middle Eastern population. </p><h3>Methods </h3><p dir="ltr">Using the data of 5,996 adult Qatari participants from the Qatar Biobank cohort, we employed adjusted logistic regression to assess the ability of various obesity and triglyceride-related indices to detect prediabetes in normal-weight (18.5 ≤ BMI <25 kg/m<sup>2</sup>) adults (≥18 years). </p><h3>Results </h3><p dir="ltr">Of the normal-weight adults, 13.62% had prediabetes. TyG-waist-to-height ratio (TyG-WHTR) was significantly associated with prediabetes among normal-weight men [OR per 1-SD 2.68; 95% CI (1.67–4.32)] and women [OR per 1-SD 2.82; 95% CI (1.61–4.94)]. Compared with other indices, TyG-WHTR had the highest area under the curve (AUC) value for prediabetes in men [AUC: 0.76, 95% CI (0.70–0.81)] and women [AUC: 0.73, 95% CI (0.66–0.80)], and performed significantly higher than other indices (p < 0.05) in detecting prediabetes in men. Tyg-WHTR shared similar diagnostic values as fasting plasma glucose (FPG). </p><h3>Discussion </h3><p dir="ltr">Our findings suggest that the TyG-WHTR index could be a better indicator of prediabetes for general clinical usage in normal weight Qatari adult men than other obesity and TyG-related indices. TyG-WHTR can help identify a person’s risk for developing prediabetes in both men and women when combined with FPG results.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Public Health<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fpubh.2023.1086771" target="_blank">https://dx.doi.org/10.3389/fpubh.2023.1086771</a></p>2023-04-06T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fpubh.2023.1086771https://figshare.com/articles/journal_contribution/The_triglyceride_glucose-waist-to-height_ratio_outperforms_obesity_and_other_triglyceride-related_parameters_in_detecting_prediabetes_in_normal-weight_Qatari_adults_A_cross-sectional_study/26661577CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/266615772023-04-06T03:00:00Z |
| spellingShingle | The triglyceride glucose-waist-to-height ratio outperforms obesity and other triglyceride-related parameters in detecting prediabetes in normal-weight Qatari adults: A cross-sectional study Neyla S. Al Akl (15189997) Biomedical and clinical sciences Medical biochemistry and metabolomics Nutrition and dietetics Health sciences Epidemiology Public health prediabetes diabetes triglyceride-glucose-related waist-to-height ratio obesity normal-weight Qatar |
| status_str | publishedVersion |
| title | The triglyceride glucose-waist-to-height ratio outperforms obesity and other triglyceride-related parameters in detecting prediabetes in normal-weight Qatari adults: A cross-sectional study |
| title_full | The triglyceride glucose-waist-to-height ratio outperforms obesity and other triglyceride-related parameters in detecting prediabetes in normal-weight Qatari adults: A cross-sectional study |
| title_fullStr | The triglyceride glucose-waist-to-height ratio outperforms obesity and other triglyceride-related parameters in detecting prediabetes in normal-weight Qatari adults: A cross-sectional study |
| title_full_unstemmed | The triglyceride glucose-waist-to-height ratio outperforms obesity and other triglyceride-related parameters in detecting prediabetes in normal-weight Qatari adults: A cross-sectional study |
| title_short | The triglyceride glucose-waist-to-height ratio outperforms obesity and other triglyceride-related parameters in detecting prediabetes in normal-weight Qatari adults: A cross-sectional study |
| title_sort | The triglyceride glucose-waist-to-height ratio outperforms obesity and other triglyceride-related parameters in detecting prediabetes in normal-weight Qatari adults: A cross-sectional study |
| topic | Biomedical and clinical sciences Medical biochemistry and metabolomics Nutrition and dietetics Health sciences Epidemiology Public health prediabetes diabetes triglyceride-glucose-related waist-to-height ratio obesity normal-weight Qatar |