CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors
<p>The interaction between cancer cells and molecular cues provided by tumor stromal cells plays a crucial role in cancer growth and progression. We have recently reported that the outcome of interaction between tumor cells and stromal cells is dependent on the gene expression signature of tum...
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2022
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| _version_ | 1864513566744248320 |
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| author | Mashael Al-toub (3563303) |
| author2 | Mohammad Almohawes (14152605) Radhakrishnan Vishnubalaji (3563306) Musaad Alfayez (3571736) Abdullah Aldahmash (3563300) Moustapha Kassem (101848) Nehad M. Alajez (7397276) |
| author2_role | author author author author author author |
| author_facet | Mashael Al-toub (3563303) Mohammad Almohawes (14152605) Radhakrishnan Vishnubalaji (3563306) Musaad Alfayez (3571736) Abdullah Aldahmash (3563300) Moustapha Kassem (101848) Nehad M. Alajez (7397276) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mashael Al-toub (3563303) Mohammad Almohawes (14152605) Radhakrishnan Vishnubalaji (3563306) Musaad Alfayez (3571736) Abdullah Aldahmash (3563300) Moustapha Kassem (101848) Nehad M. Alajez (7397276) |
| dc.date.none.fl_str_mv | 2022-11-22T21:16:39Z |
| dc.identifier.none.fl_str_mv | 10.1038/s41420-019-0169-3 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/CXCR7_signaling_promotes_breast_cancer_survival_in_response_to_mesenchymal_stromal_stem_cell-derived_factors/21598056 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biochemistry and cell biology Oncology and carcinogenesis Cancer Research Cell Biology Cellular and Molecular Neuroscience Immunology |
| dc.title.none.fl_str_mv | CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p>The interaction between cancer cells and molecular cues provided by tumor stromal cells plays a crucial role in cancer growth and progression. We have recently reported that the outcome of interaction between tumor cells and stromal cells is dependent on the gene expression signature of tumor cells. In the current study, we observed that several cancer cell lines, e.g., MCF7 breast cancer line, exhibited growth advantage when cultured in the presence of conditioned media (CM) derived from human bone marrow stromal stem cells (hBMSCs). Regarding the underlying molecular mechanism, we have identified CXCR7 as highly expressed by MCF7 cells and that it mediated the enhanced growth in response to hBMSC CM. Regarding the clinical relevance, we found an inverse correlation between the level of tumor gene expression of CXCR7 in bladder, breast, cervical, kidney, liver, lung, pancreatic, stomach, and uterine cancers, and patients’ overall survival. Interestingly, significant positive correlation between CXCR7 and CXCL12 gene expression (Pearson = 0.3, p = 2.0 × 10–16) was observed in breast cancer patients, suggesting a biological role for the CXCR7/CXCL12 genetic circuit in breast cancer biology. Our data provide insight into the molecular mechanisms by which stromal-derived microenvironmental cues mediate CXCR7 signaling and growth enhancement of breast cancer cells. Therapeutic targeting of this circuit might provide novel therapeutic opportunity for breast cancer.</p><h2>Other Information</h2> <p> Published in: Cell Death Discovery<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1038/s41420-019-0169-3" target="_blank">http://dx.doi.org/10.1038/s41420-019-0169-3</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_4396ab74d6497ac90d2e9b071b37f0fb |
| identifier_str_mv | 10.1038/s41420-019-0169-3 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21598056 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factorsMashael Al-toub (3563303)Mohammad Almohawes (14152605)Radhakrishnan Vishnubalaji (3563306)Musaad Alfayez (3571736)Abdullah Aldahmash (3563300)Moustapha Kassem (101848)Nehad M. Alajez (7397276)Biochemistry and cell biologyOncology and carcinogenesisCancer ResearchCell BiologyCellular and Molecular NeuroscienceImmunology<p>The interaction between cancer cells and molecular cues provided by tumor stromal cells plays a crucial role in cancer growth and progression. We have recently reported that the outcome of interaction between tumor cells and stromal cells is dependent on the gene expression signature of tumor cells. In the current study, we observed that several cancer cell lines, e.g., MCF7 breast cancer line, exhibited growth advantage when cultured in the presence of conditioned media (CM) derived from human bone marrow stromal stem cells (hBMSCs). Regarding the underlying molecular mechanism, we have identified CXCR7 as highly expressed by MCF7 cells and that it mediated the enhanced growth in response to hBMSC CM. Regarding the clinical relevance, we found an inverse correlation between the level of tumor gene expression of CXCR7 in bladder, breast, cervical, kidney, liver, lung, pancreatic, stomach, and uterine cancers, and patients’ overall survival. Interestingly, significant positive correlation between CXCR7 and CXCL12 gene expression (Pearson = 0.3, p = 2.0 × 10–16) was observed in breast cancer patients, suggesting a biological role for the CXCR7/CXCL12 genetic circuit in breast cancer biology. Our data provide insight into the molecular mechanisms by which stromal-derived microenvironmental cues mediate CXCR7 signaling and growth enhancement of breast cancer cells. Therapeutic targeting of this circuit might provide novel therapeutic opportunity for breast cancer.</p><h2>Other Information</h2> <p> Published in: Cell Death Discovery<br> License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1038/s41420-019-0169-3" target="_blank">http://dx.doi.org/10.1038/s41420-019-0169-3</a></p>2022-11-22T21:16:39ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1038/s41420-019-0169-3https://figshare.com/articles/journal_contribution/CXCR7_signaling_promotes_breast_cancer_survival_in_response_to_mesenchymal_stromal_stem_cell-derived_factors/21598056CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215980562022-11-22T21:16:39Z |
| spellingShingle | CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors Mashael Al-toub (3563303) Biochemistry and cell biology Oncology and carcinogenesis Cancer Research Cell Biology Cellular and Molecular Neuroscience Immunology |
| status_str | publishedVersion |
| title | CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors |
| title_full | CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors |
| title_fullStr | CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors |
| title_full_unstemmed | CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors |
| title_short | CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors |
| title_sort | CXCR7 signaling promotes breast cancer survival in response to mesenchymal stromal stem cell-derived factors |
| topic | Biochemistry and cell biology Oncology and carcinogenesis Cancer Research Cell Biology Cellular and Molecular Neuroscience Immunology |