Viral-Induced Enhanced Disease Illness
<p dir="ltr">Understanding immune responses to viral infections is crucial to progress in the quest for effective infection prevention and control. The host immunity involves various mechanisms to combat viral infections. Under certain circumstances, a viral infection or vaccination...
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2018
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| _version_ | 1864513525878095872 |
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| author | Maria K. Smatti (4675852) |
| author2 | Asmaa A. Al Thani (10494576) Hadi M. Yassine (4675846) |
| author2_role | author author |
| author_facet | Maria K. Smatti (4675852) Asmaa A. Al Thani (10494576) Hadi M. Yassine (4675846) |
| author_role | author |
| dc.creator.none.fl_str_mv | Maria K. Smatti (4675852) Asmaa A. Al Thani (10494576) Hadi M. Yassine (4675846) |
| dc.date.none.fl_str_mv | 2018-12-05T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fmicb.2018.02991 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Viral-Induced_Enhanced_Disease_Illness/25333714 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Medical microbiology antibody-dependent enhancement Fc receptors complement immune response viral infections |
| dc.title.none.fl_str_mv | Viral-Induced Enhanced Disease Illness |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Understanding immune responses to viral infections is crucial to progress in the quest for effective infection prevention and control. The host immunity involves various mechanisms to combat viral infections. Under certain circumstances, a viral infection or vaccination may result in a subverted immune system, which may lead to an exacerbated illness. Clinical evidence of enhanced illness by preexisting antibodies from vaccination, infection or maternal passive immunity is available for several viruses and is presumptively proposed for other viruses. Multiple mechanisms have been proposed to explain this phenomenon. It has been confirmed that certain infection- and/or vaccine-induced immunity could exacerbate viral infectivity in Fc receptor- or complement bearing cells- mediated mechanisms. Considering that antibody dependent enhancement (ADE) is a major obstacle in vaccine development, there are continues efforts to understand the underlying mechanisms through identification of the epitopes and antibodies responsible for disease enhancement or protection. This review discusses the recent findings on virally induced ADE, and highlights the potential mechanisms leading to this condition.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Microbiology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fmicb.2018.02991" target="_blank">https://dx.doi.org/10.3389/fmicb.2018.02991</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_45a2b31855b60a348d44670dd013cbf2 |
| identifier_str_mv | 10.3389/fmicb.2018.02991 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25333714 |
| publishDate | 2018 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Viral-Induced Enhanced Disease IllnessMaria K. Smatti (4675852)Asmaa A. Al Thani (10494576)Hadi M. Yassine (4675846)Biomedical and clinical sciencesMedical microbiologyantibody-dependent enhancementFc receptorscomplementimmune responseviral infections<p dir="ltr">Understanding immune responses to viral infections is crucial to progress in the quest for effective infection prevention and control. The host immunity involves various mechanisms to combat viral infections. Under certain circumstances, a viral infection or vaccination may result in a subverted immune system, which may lead to an exacerbated illness. Clinical evidence of enhanced illness by preexisting antibodies from vaccination, infection or maternal passive immunity is available for several viruses and is presumptively proposed for other viruses. Multiple mechanisms have been proposed to explain this phenomenon. It has been confirmed that certain infection- and/or vaccine-induced immunity could exacerbate viral infectivity in Fc receptor- or complement bearing cells- mediated mechanisms. Considering that antibody dependent enhancement (ADE) is a major obstacle in vaccine development, there are continues efforts to understand the underlying mechanisms through identification of the epitopes and antibodies responsible for disease enhancement or protection. This review discusses the recent findings on virally induced ADE, and highlights the potential mechanisms leading to this condition.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Microbiology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fmicb.2018.02991" target="_blank">https://dx.doi.org/10.3389/fmicb.2018.02991</a></p>2018-12-05T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fmicb.2018.02991https://figshare.com/articles/journal_contribution/Viral-Induced_Enhanced_Disease_Illness/25333714CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/253337142018-12-05T03:00:00Z |
| spellingShingle | Viral-Induced Enhanced Disease Illness Maria K. Smatti (4675852) Biomedical and clinical sciences Medical microbiology antibody-dependent enhancement Fc receptors complement immune response viral infections |
| status_str | publishedVersion |
| title | Viral-Induced Enhanced Disease Illness |
| title_full | Viral-Induced Enhanced Disease Illness |
| title_fullStr | Viral-Induced Enhanced Disease Illness |
| title_full_unstemmed | Viral-Induced Enhanced Disease Illness |
| title_short | Viral-Induced Enhanced Disease Illness |
| title_sort | Viral-Induced Enhanced Disease Illness |
| topic | Biomedical and clinical sciences Medical microbiology antibody-dependent enhancement Fc receptors complement immune response viral infections |