Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model

Transcriptome Profile Identifies Actin as an Essential Regulator of Cardiac Myosin Binding Protein C3 Hypertrophic Cardiomyopathy in a Zebrafish Model

<div><p>Variants in cardiac myosin-binding protein C (cMyBP-C) are the leading cause of inherited hypertrophic cardiomyopathy (HCM), demonstrating the key role that cMyBP-C plays in the heart’s contractile machinery. To investigate the c-MYBPC3 HCM-related cardiac impairment, we generate...

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Main Author: Sahar Isa Da’as (18288880) (author)
Other Authors: Waseem Hasan (17280670) (author), Rola Salem (18288883) (author), Nadine Younes (14779150) (author), Doua Abdelrahman (17280667) (author), Iman A. Mohamed (18288886) (author), Arwa Aldaalis (13355328) (author), Ramzi Temanni (671528) (author), Lisa Sara Mathew (17886698) (author), Stephan Lorenz (466378) (author), Magdi Yacoub (6893000) (author), Michail Nomikos (17563188) (author), Gheyath K. Nasrallah (9200525) (author), Khalid A. Fakhro (3158862) (author)
Published: 2022
Subjects:
Biological sciences
Zoology
Chemical sciences
Inorganic chemistry
Organic chemistry
Physical chemistry
Theoretical and computational chemistry
hypertrophic cardiomyopathy
HCM
c-MYBPC3
actin
RNA seq
zebrafish knockout
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