eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways

eIF4A inhibition prevents the onset of cytokine-induced muscle wasting by blocking the STAT3 and iNOS pathways

<div><p>Cachexia is a deadly muscle wasting syndrome that arises under conditions linked to chronic inflammation, such as cancer. Cytokines, including interferon γ (IFNγ), tumor necrosis factor α (TNFα) and interleukin-6 (IL-6), and their downstream effectors such as Signal Transducer an...

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Bibliographic Details
Main Author: Zvi Cramer (10742876) (author)
Other Authors: Jason Sadek (18629365) (author), Gabriela Galicia Vazquez (18697006) (author), Sergio Di Marco (387749) (author), Arnim Pause (265677) (author), Jerry Pelletier (28518) (author), Imed-Eddine Gallouzi (387751) (author)
Published: 2018
Subjects:
Biomedical and clinical sciences
Clinical sciences
Oncology and carcinogenesis
Cachexia
Muscle wasting syndrome
Chronic inflammation
Cancer
Cytokines
Interferon γ (IFNγ)
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