Paracrine Mechanisms of Mesenchymal Stromal Cells in Angiogenesis
<p dir="ltr">The role of the mesenchymal stromal cell- (MSC-) derived secretome is becoming increasingly intriguing from a clinical perspective due to its ability to stimulate endogenous tissue repair processes as well as its effective regulation of the immune system, mimicking the t...
محفوظ في:
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2020
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| _version_ | 1864513511821934592 |
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| author | Selma Maacha (501715) |
| author2 | Heba Sidahmed (2632471) Shana Jacob (17280790) Giusy Gentilcore (15112577) Rita Calzone (7594709) Jean-Charles Grivel (284645) Chiara Cugno (3441302) |
| author2_role | author author author author author author |
| author_facet | Selma Maacha (501715) Heba Sidahmed (2632471) Shana Jacob (17280790) Giusy Gentilcore (15112577) Rita Calzone (7594709) Jean-Charles Grivel (284645) Chiara Cugno (3441302) |
| author_role | author |
| dc.creator.none.fl_str_mv | Selma Maacha (501715) Heba Sidahmed (2632471) Shana Jacob (17280790) Giusy Gentilcore (15112577) Rita Calzone (7594709) Jean-Charles Grivel (284645) Chiara Cugno (3441302) |
| dc.date.none.fl_str_mv | 2020-03-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1155/2020/4356359 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Paracrine_Mechanisms_of_Mesenchymal_Stromal_Cells_in_Angiogenesis/26021071 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Medical biotechnology Bone marrow stromal cells Dermal tissues Placenta Anti-inflammatory effects Tissue regeneration Angiogenesis Brain injury Limb ischemia Proteins |
| dc.title.none.fl_str_mv | Paracrine Mechanisms of Mesenchymal Stromal Cells in Angiogenesis |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The role of the mesenchymal stromal cell- (MSC-) derived secretome is becoming increasingly intriguing from a clinical perspective due to its ability to stimulate endogenous tissue repair processes as well as its effective regulation of the immune system, mimicking the therapeutic effects produced by the MSCs. The secretome is a composite product secreted by MSC in vitro (in conditioned medium) and in vivo (in the extracellular milieu), consisting of a protein soluble fraction (mostly growth factors and cytokines) and a vesicular component, extracellular vesicles (EVs), which transfer proteins, lipids, and genetic material. MSC-derived secretome differs based on the tissue from which the MSCs are isolated and under specific conditions (e.g., preconditioning or priming) suggesting that clinical applications should be tailored by choosing the tissue of origin and a priming regimen to specifically correct a given pathology. MSC-derived secretome mediates beneficial angiogenic effects in a variety of tissue injury-related diseases. This supports the current effort to develop cell-free therapeutic products that bring both clinical benefits (reduced immunogenicity, persistence in vivo, and no genotoxicity associated with long-term cell cultures) and manufacturing advantages (reduced costs, availability of large quantities of off-the-shelf products, and lower regulatory burden). In the present review, we aim to give a comprehensive picture of the numerous components of the secretome produced by MSCs derived from the most common tissue sources for clinical use (e.g., AT, BM, and CB). We focus on the factors involved in the complex regulation of angiogenic processes.</p><h2>Other Information</h2><p dir="ltr">Published in: Stem Cells International<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1155/2020/4356359" target="_blank">https://dx.doi.org/10.1155/2020/4356359</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_481d0d67f436c2aef7feee6fbb977cf5 |
| identifier_str_mv | 10.1155/2020/4356359 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/26021071 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Paracrine Mechanisms of Mesenchymal Stromal Cells in AngiogenesisSelma Maacha (501715)Heba Sidahmed (2632471)Shana Jacob (17280790)Giusy Gentilcore (15112577)Rita Calzone (7594709)Jean-Charles Grivel (284645)Chiara Cugno (3441302)Biomedical and clinical sciencesClinical sciencesMedical biochemistry and metabolomicsMedical biotechnologyBone marrow stromal cellsDermal tissuesPlacentaAnti-inflammatory effectsTissue regenerationAngiogenesisBrain injuryLimb ischemiaProteins<p dir="ltr">The role of the mesenchymal stromal cell- (MSC-) derived secretome is becoming increasingly intriguing from a clinical perspective due to its ability to stimulate endogenous tissue repair processes as well as its effective regulation of the immune system, mimicking the therapeutic effects produced by the MSCs. The secretome is a composite product secreted by MSC in vitro (in conditioned medium) and in vivo (in the extracellular milieu), consisting of a protein soluble fraction (mostly growth factors and cytokines) and a vesicular component, extracellular vesicles (EVs), which transfer proteins, lipids, and genetic material. MSC-derived secretome differs based on the tissue from which the MSCs are isolated and under specific conditions (e.g., preconditioning or priming) suggesting that clinical applications should be tailored by choosing the tissue of origin and a priming regimen to specifically correct a given pathology. MSC-derived secretome mediates beneficial angiogenic effects in a variety of tissue injury-related diseases. This supports the current effort to develop cell-free therapeutic products that bring both clinical benefits (reduced immunogenicity, persistence in vivo, and no genotoxicity associated with long-term cell cultures) and manufacturing advantages (reduced costs, availability of large quantities of off-the-shelf products, and lower regulatory burden). In the present review, we aim to give a comprehensive picture of the numerous components of the secretome produced by MSCs derived from the most common tissue sources for clinical use (e.g., AT, BM, and CB). We focus on the factors involved in the complex regulation of angiogenic processes.</p><h2>Other Information</h2><p dir="ltr">Published in: Stem Cells International<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1155/2020/4356359" target="_blank">https://dx.doi.org/10.1155/2020/4356359</a></p>2020-03-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1155/2020/4356359https://figshare.com/articles/journal_contribution/Paracrine_Mechanisms_of_Mesenchymal_Stromal_Cells_in_Angiogenesis/26021071CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/260210712020-03-01T00:00:00Z |
| spellingShingle | Paracrine Mechanisms of Mesenchymal Stromal Cells in Angiogenesis Selma Maacha (501715) Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Medical biotechnology Bone marrow stromal cells Dermal tissues Placenta Anti-inflammatory effects Tissue regeneration Angiogenesis Brain injury Limb ischemia Proteins |
| status_str | publishedVersion |
| title | Paracrine Mechanisms of Mesenchymal Stromal Cells in Angiogenesis |
| title_full | Paracrine Mechanisms of Mesenchymal Stromal Cells in Angiogenesis |
| title_fullStr | Paracrine Mechanisms of Mesenchymal Stromal Cells in Angiogenesis |
| title_full_unstemmed | Paracrine Mechanisms of Mesenchymal Stromal Cells in Angiogenesis |
| title_short | Paracrine Mechanisms of Mesenchymal Stromal Cells in Angiogenesis |
| title_sort | Paracrine Mechanisms of Mesenchymal Stromal Cells in Angiogenesis |
| topic | Biomedical and clinical sciences Clinical sciences Medical biochemistry and metabolomics Medical biotechnology Bone marrow stromal cells Dermal tissues Placenta Anti-inflammatory effects Tissue regeneration Angiogenesis Brain injury Limb ischemia Proteins |