Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance
<p dir="ltr">Cancer is a complex disease displaying a variety of cell states and phenotypes. This diversity, known as cancer cell plasticity, confers cancer cells the ability to change in response to their environment, leading to increased tumor diversity and drug resistance. This re...
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| مؤلفون آخرون: | , , , , , , , , , , , , , , , |
| منشور في: |
2024
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إضافة وسم
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| _version_ | 1864513544642363392 |
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| author | Gh Rasool Bhat (13038132) |
| author2 | Itty Sethi (6701723) Hana Q. Sadida (15376385) Bilal Rah (137862) Rashid Mir (2616949) Naseh Algehainy (21633089) Ibrahim Altedlawi Albalawi (21734558) Tariq Masoodi (8117702) Gowtham Kumar Subbaraj (17807615) Farrukh Jamal (8605026) Mayank Singh (793077) Rakesh Kumar (8432) Muzafar A. Macha (11605200) Shahab Uddin (154400) Ammira S. Al-Shabeeb Akil (15376391) Mohammad Haris (564809) Ajaz A. Bhat (12984701) |
| author2_role | author author author author author author author author author author author author author author author author |
| author_facet | Gh Rasool Bhat (13038132) Itty Sethi (6701723) Hana Q. Sadida (15376385) Bilal Rah (137862) Rashid Mir (2616949) Naseh Algehainy (21633089) Ibrahim Altedlawi Albalawi (21734558) Tariq Masoodi (8117702) Gowtham Kumar Subbaraj (17807615) Farrukh Jamal (8605026) Mayank Singh (793077) Rakesh Kumar (8432) Muzafar A. Macha (11605200) Shahab Uddin (154400) Ammira S. Al-Shabeeb Akil (15376391) Mohammad Haris (564809) Ajaz A. Bhat (12984701) |
| author_role | author |
| dc.creator.none.fl_str_mv | Gh Rasool Bhat (13038132) Itty Sethi (6701723) Hana Q. Sadida (15376385) Bilal Rah (137862) Rashid Mir (2616949) Naseh Algehainy (21633089) Ibrahim Altedlawi Albalawi (21734558) Tariq Masoodi (8117702) Gowtham Kumar Subbaraj (17807615) Farrukh Jamal (8605026) Mayank Singh (793077) Rakesh Kumar (8432) Muzafar A. Macha (11605200) Shahab Uddin (154400) Ammira S. Al-Shabeeb Akil (15376391) Mohammad Haris (564809) Ajaz A. Bhat (12984701) |
| dc.date.none.fl_str_mv | 2024-02-08T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s10555-024-10172-z |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Cancer_cell_plasticity_from_cellular_molecular_and_genetic_mechanisms_to_tumor_heterogeneity_and_drug_resistance/29590346 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Cancer cell plasticity Cancer stem cells Epithelial-mesenchymal transition Tumor heterogeneity Drug resistance Targeted therapies |
| dc.title.none.fl_str_mv | Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Cancer is a complex disease displaying a variety of cell states and phenotypes. This diversity, known as cancer cell plasticity, confers cancer cells the ability to change in response to their environment, leading to increased tumor diversity and drug resistance. This review explores the intricate landscape of cancer cell plasticity, offering a deep dive into the cellular, molecular, and genetic mechanisms that underlie this phenomenon. Cancer cell plasticity is intertwined with processes such as epithelial-mesenchymal transition and the acquisition of stem cell–like features. These processes are pivotal in the development and progression of tumors, contributing to the multifaceted nature of cancer and the challenges associated with its treatment. Despite significant advancements in targeted therapies, cancer cell adaptability and subsequent therapy-induced resistance remain persistent obstacles in achieving consistent, successful cancer treatment outcomes. Our review delves into the array of mechanisms cancer cells exploit to maintain plasticity, including epigenetic modifications, alterations in signaling pathways, and environmental interactions. We discuss strategies to counteract cancer cell plasticity, such as targeting specific cellular pathways and employing combination therapies. These strategies promise to enhance the efficacy of cancer treatments and mitigate therapy resistance. In conclusion, this review offers a holistic, detailed exploration of cancer cell plasticity, aiming to bolster the understanding and approach toward tackling the challenges posed by tumor heterogeneity and drug resistance. As articulated in this review, the delineation of cellular, molecular, and genetic mechanisms underlying tumor heterogeneity and drug resistance seeks to contribute substantially to the progress in cancer therapeutics and the advancement of precision medicine, ultimately enhancing the prospects for effective cancer treatment and patient outcomes.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancer and Metastasis Reviews<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s10555-024-10172-z" target="_blank">https://dx.doi.org/10.1007/s10555-024-10172-z</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_485791cf656dd6e0acdbe979b078e5d5 |
| identifier_str_mv | 10.1007/s10555-024-10172-z |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/29590346 |
| publishDate | 2024 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistanceGh Rasool Bhat (13038132)Itty Sethi (6701723)Hana Q. Sadida (15376385)Bilal Rah (137862)Rashid Mir (2616949)Naseh Algehainy (21633089)Ibrahim Altedlawi Albalawi (21734558)Tariq Masoodi (8117702)Gowtham Kumar Subbaraj (17807615)Farrukh Jamal (8605026)Mayank Singh (793077)Rakesh Kumar (8432)Muzafar A. Macha (11605200)Shahab Uddin (154400)Ammira S. Al-Shabeeb Akil (15376391)Mohammad Haris (564809)Ajaz A. Bhat (12984701)Biomedical and clinical sciencesOncology and carcinogenesisPharmacology and pharmaceutical sciencesCancer cell plasticityCancer stem cellsEpithelial-mesenchymal transitionTumor heterogeneityDrug resistanceTargeted therapies<p dir="ltr">Cancer is a complex disease displaying a variety of cell states and phenotypes. This diversity, known as cancer cell plasticity, confers cancer cells the ability to change in response to their environment, leading to increased tumor diversity and drug resistance. This review explores the intricate landscape of cancer cell plasticity, offering a deep dive into the cellular, molecular, and genetic mechanisms that underlie this phenomenon. Cancer cell plasticity is intertwined with processes such as epithelial-mesenchymal transition and the acquisition of stem cell–like features. These processes are pivotal in the development and progression of tumors, contributing to the multifaceted nature of cancer and the challenges associated with its treatment. Despite significant advancements in targeted therapies, cancer cell adaptability and subsequent therapy-induced resistance remain persistent obstacles in achieving consistent, successful cancer treatment outcomes. Our review delves into the array of mechanisms cancer cells exploit to maintain plasticity, including epigenetic modifications, alterations in signaling pathways, and environmental interactions. We discuss strategies to counteract cancer cell plasticity, such as targeting specific cellular pathways and employing combination therapies. These strategies promise to enhance the efficacy of cancer treatments and mitigate therapy resistance. In conclusion, this review offers a holistic, detailed exploration of cancer cell plasticity, aiming to bolster the understanding and approach toward tackling the challenges posed by tumor heterogeneity and drug resistance. As articulated in this review, the delineation of cellular, molecular, and genetic mechanisms underlying tumor heterogeneity and drug resistance seeks to contribute substantially to the progress in cancer therapeutics and the advancement of precision medicine, ultimately enhancing the prospects for effective cancer treatment and patient outcomes.</p><h2>Other Information</h2><p dir="ltr">Published in: Cancer and Metastasis Reviews<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1007/s10555-024-10172-z" target="_blank">https://dx.doi.org/10.1007/s10555-024-10172-z</a></p>2024-02-08T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s10555-024-10172-zhttps://figshare.com/articles/journal_contribution/Cancer_cell_plasticity_from_cellular_molecular_and_genetic_mechanisms_to_tumor_heterogeneity_and_drug_resistance/29590346CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/295903462024-02-08T03:00:00Z |
| spellingShingle | Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance Gh Rasool Bhat (13038132) Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Cancer cell plasticity Cancer stem cells Epithelial-mesenchymal transition Tumor heterogeneity Drug resistance Targeted therapies |
| status_str | publishedVersion |
| title | Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance |
| title_full | Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance |
| title_fullStr | Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance |
| title_full_unstemmed | Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance |
| title_short | Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance |
| title_sort | Cancer cell plasticity: from cellular, molecular, and genetic mechanisms to tumor heterogeneity and drug resistance |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis Pharmacology and pharmaceutical sciences Cancer cell plasticity Cancer stem cells Epithelial-mesenchymal transition Tumor heterogeneity Drug resistance Targeted therapies |