Over Fifty Years of Life, Death, and Cannibalism: A Historical Recollection of Apoptosis and Autophagy
<div><p>Research in biomedical sciences has changed dramatically over the past fifty years. There is no doubt that the discovery of apoptosis and autophagy as two highly synchronized and regulated mechanisms in cellular homeostasis are among the most important discoveries in these decade...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , |
| منشور في: |
2021
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إضافة وسم
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| _version_ | 1864513515312644096 |
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| author | Mahmoud Izadi (12899508) |
| author2 | Tayyiba Akbar Ali (14152572) Ehsan Pourkarimi (541179) |
| author2_role | author author |
| author_facet | Mahmoud Izadi (12899508) Tayyiba Akbar Ali (14152572) Ehsan Pourkarimi (541179) |
| author_role | author |
| dc.creator.none.fl_str_mv | Mahmoud Izadi (12899508) Tayyiba Akbar Ali (14152572) Ehsan Pourkarimi (541179) |
| dc.date.none.fl_str_mv | 2021-11-18T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/ijms222212466 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Over_Fifty_Years_of_Life_Death_and_Cannibalism_A_Historical_Recollection_of_Apoptosis_and_Autophagy/25878034 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Microbiology apoptosis autophagy C. elegans caspase Bcl-2 Apaf1 electron microscopy |
| dc.title.none.fl_str_mv | Over Fifty Years of Life, Death, and Cannibalism: A Historical Recollection of Apoptosis and Autophagy |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <div><p>Research in biomedical sciences has changed dramatically over the past fifty years. There is no doubt that the discovery of apoptosis and autophagy as two highly synchronized and regulated mechanisms in cellular homeostasis are among the most important discoveries in these decades. Along with the advancement in molecular biology, identifying the genetic players in apoptosis and autophagy has shed light on our understanding of their function in physiological and pathological conditions. In this review, we first describe the history of key discoveries in apoptosis with a molecular insight and continue with apoptosis pathways and their regulation. We touch upon the role of apoptosis in human health and its malfunction in several diseases. We discuss the path to the morphological and molecular discovery of autophagy. Moreover, we dive deep into the precise regulation of autophagy and recent findings from basic research to clinical applications of autophagy modulation in human health and illnesses and the available therapies for many diseases caused by impaired autophagy. We conclude with the exciting crosstalk between apoptosis and autophagy, from the early discoveries to recent findings.</p><p> </p></div><h2>Other Information</h2> <p> Published in: International Journal of Molecular Sciences<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijms222212466" target="_blank">https://dx.doi.org/10.3390/ijms222212466</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_4859bd0e5b4f06dd315bced1890f49fa |
| identifier_str_mv | 10.3390/ijms222212466 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25878034 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Over Fifty Years of Life, Death, and Cannibalism: A Historical Recollection of Apoptosis and AutophagyMahmoud Izadi (12899508)Tayyiba Akbar Ali (14152572)Ehsan Pourkarimi (541179)Biological sciencesMicrobiologyapoptosisautophagyC. eleganscaspaseBcl-2Apaf1electron microscopy<div><p>Research in biomedical sciences has changed dramatically over the past fifty years. There is no doubt that the discovery of apoptosis and autophagy as two highly synchronized and regulated mechanisms in cellular homeostasis are among the most important discoveries in these decades. Along with the advancement in molecular biology, identifying the genetic players in apoptosis and autophagy has shed light on our understanding of their function in physiological and pathological conditions. In this review, we first describe the history of key discoveries in apoptosis with a molecular insight and continue with apoptosis pathways and their regulation. We touch upon the role of apoptosis in human health and its malfunction in several diseases. We discuss the path to the morphological and molecular discovery of autophagy. Moreover, we dive deep into the precise regulation of autophagy and recent findings from basic research to clinical applications of autophagy modulation in human health and illnesses and the available therapies for many diseases caused by impaired autophagy. We conclude with the exciting crosstalk between apoptosis and autophagy, from the early discoveries to recent findings.</p><p> </p></div><h2>Other Information</h2> <p> Published in: International Journal of Molecular Sciences<br> License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3390/ijms222212466" target="_blank">https://dx.doi.org/10.3390/ijms222212466</a></p>2021-11-18T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/ijms222212466https://figshare.com/articles/journal_contribution/Over_Fifty_Years_of_Life_Death_and_Cannibalism_A_Historical_Recollection_of_Apoptosis_and_Autophagy/25878034CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/258780342021-11-18T03:00:00Z |
| spellingShingle | Over Fifty Years of Life, Death, and Cannibalism: A Historical Recollection of Apoptosis and Autophagy Mahmoud Izadi (12899508) Biological sciences Microbiology apoptosis autophagy C. elegans caspase Bcl-2 Apaf1 electron microscopy |
| status_str | publishedVersion |
| title | Over Fifty Years of Life, Death, and Cannibalism: A Historical Recollection of Apoptosis and Autophagy |
| title_full | Over Fifty Years of Life, Death, and Cannibalism: A Historical Recollection of Apoptosis and Autophagy |
| title_fullStr | Over Fifty Years of Life, Death, and Cannibalism: A Historical Recollection of Apoptosis and Autophagy |
| title_full_unstemmed | Over Fifty Years of Life, Death, and Cannibalism: A Historical Recollection of Apoptosis and Autophagy |
| title_short | Over Fifty Years of Life, Death, and Cannibalism: A Historical Recollection of Apoptosis and Autophagy |
| title_sort | Over Fifty Years of Life, Death, and Cannibalism: A Historical Recollection of Apoptosis and Autophagy |
| topic | Biological sciences Microbiology apoptosis autophagy C. elegans caspase Bcl-2 Apaf1 electron microscopy |