Targeting deregulated oxidative stress in skin inflammatory diseases: An update on clinical importance
<p dir="ltr">Skin, the largest vital organ of the human body, provides the first line of defense against biological, non-biological and xenobiotics exposure. Over the years, due to increased anthropogenic activities including industrialization and pollution, a steep increase in cutan...
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| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , |
| منشور في: |
2022
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| الموضوعات: | |
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إضافة وسم
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| _version_ | 1864513538551185408 |
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| author | Abdul Q. Khan (14153247) |
| author2 | Maha Victor Agha (16932492) Khalid Sultan A.M. Sheikhan (17380450) Shahd M. Younis (17380453) Maha Al Tamimi (17380456) Majid Alam (14158959) Aamir Ahmad (233201) Shahab Uddin (154400) Joerg Buddenkotte (6293584) Martin Steinhoff (5340194) |
| author2_role | author author author author author author author author author |
| author_facet | Abdul Q. Khan (14153247) Maha Victor Agha (16932492) Khalid Sultan A.M. Sheikhan (17380450) Shahd M. Younis (17380453) Maha Al Tamimi (17380456) Majid Alam (14158959) Aamir Ahmad (233201) Shahab Uddin (154400) Joerg Buddenkotte (6293584) Martin Steinhoff (5340194) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abdul Q. Khan (14153247) Maha Victor Agha (16932492) Khalid Sultan A.M. Sheikhan (17380450) Shahd M. Younis (17380453) Maha Al Tamimi (17380456) Majid Alam (14158959) Aamir Ahmad (233201) Shahab Uddin (154400) Joerg Buddenkotte (6293584) Martin Steinhoff (5340194) |
| dc.date.none.fl_str_mv | 2022-10-01T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.biopha.2022.113601 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Targeting_deregulated_oxidative_stress_in_skin_inflammatory_diseases_An_update_on_clinical_importance/24551455 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Clinical sciences Chemical sciences Medicinal and biomolecular chemistry Skin diseases Natural products Signaling mechanisms Xenobiotics and clinical challenges |
| dc.title.none.fl_str_mv | Targeting deregulated oxidative stress in skin inflammatory diseases: An update on clinical importance |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Skin, the largest vital organ of the human body, provides the first line of defense against biological, non-biological and xenobiotics exposure. Over the years, due to increased anthropogenic activities including industrialization and pollution, a steep increase in cutaneous pathological conditions such as malignancies, dermatitis, and psoriasis has been detected. Indeed, due to the complex nature of cutaneous inflammatory diseases, further investigations are required to produce a better outcome in patient care. However, research obtained over the last few decades has revolutionized the understanding of cutaneous disease pathogenesis and therapeutic developments. In this line, increasing data from pre-clinical and clinical studies implicates the crucial role of oxidative stress in pathogenesis and complications of cutaneous inflammatory diseases, including atopic dermatitis and psoriasis. Taking into consideration the current challenge, this review aims to highlight the novel updates exploring reactive oxygen species (ROS) induced mechanistic signaling mechanisms in conjunction with pathways converging towards atopic dermatitis and psoriasis. Additionally, an exploration of the clinical importance of natural products for management of cutaneous diseases has been included. Overall, this review highlights the therapeutic importance of targeting oxidative stress in the pathogenesis, symptoms, and complications of inflammatory diseases of the skin.</p><h2>Other Information</h2><p dir="ltr">Published in: Biomedicine & Pharmacotherapy<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.biopha.2022.113601" target="_blank">https://dx.doi.org/10.1016/j.biopha.2022.113601</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_48ab13f08e7b39273a1573b434aff796 |
| identifier_str_mv | 10.1016/j.biopha.2022.113601 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24551455 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Targeting deregulated oxidative stress in skin inflammatory diseases: An update on clinical importanceAbdul Q. Khan (14153247)Maha Victor Agha (16932492)Khalid Sultan A.M. Sheikhan (17380450)Shahd M. Younis (17380453)Maha Al Tamimi (17380456)Majid Alam (14158959)Aamir Ahmad (233201)Shahab Uddin (154400)Joerg Buddenkotte (6293584)Martin Steinhoff (5340194)Biological sciencesBiochemistry and cell biologyBiomedical and clinical sciencesClinical sciencesChemical sciencesMedicinal and biomolecular chemistrySkin diseasesNatural productsSignaling mechanismsXenobioticsand clinical challenges<p dir="ltr">Skin, the largest vital organ of the human body, provides the first line of defense against biological, non-biological and xenobiotics exposure. Over the years, due to increased anthropogenic activities including industrialization and pollution, a steep increase in cutaneous pathological conditions such as malignancies, dermatitis, and psoriasis has been detected. Indeed, due to the complex nature of cutaneous inflammatory diseases, further investigations are required to produce a better outcome in patient care. However, research obtained over the last few decades has revolutionized the understanding of cutaneous disease pathogenesis and therapeutic developments. In this line, increasing data from pre-clinical and clinical studies implicates the crucial role of oxidative stress in pathogenesis and complications of cutaneous inflammatory diseases, including atopic dermatitis and psoriasis. Taking into consideration the current challenge, this review aims to highlight the novel updates exploring reactive oxygen species (ROS) induced mechanistic signaling mechanisms in conjunction with pathways converging towards atopic dermatitis and psoriasis. Additionally, an exploration of the clinical importance of natural products for management of cutaneous diseases has been included. Overall, this review highlights the therapeutic importance of targeting oxidative stress in the pathogenesis, symptoms, and complications of inflammatory diseases of the skin.</p><h2>Other Information</h2><p dir="ltr">Published in: Biomedicine & Pharmacotherapy<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.biopha.2022.113601" target="_blank">https://dx.doi.org/10.1016/j.biopha.2022.113601</a></p>2022-10-01T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.biopha.2022.113601https://figshare.com/articles/journal_contribution/Targeting_deregulated_oxidative_stress_in_skin_inflammatory_diseases_An_update_on_clinical_importance/24551455CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/245514552022-10-01T00:00:00Z |
| spellingShingle | Targeting deregulated oxidative stress in skin inflammatory diseases: An update on clinical importance Abdul Q. Khan (14153247) Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Clinical sciences Chemical sciences Medicinal and biomolecular chemistry Skin diseases Natural products Signaling mechanisms Xenobiotics and clinical challenges |
| status_str | publishedVersion |
| title | Targeting deregulated oxidative stress in skin inflammatory diseases: An update on clinical importance |
| title_full | Targeting deregulated oxidative stress in skin inflammatory diseases: An update on clinical importance |
| title_fullStr | Targeting deregulated oxidative stress in skin inflammatory diseases: An update on clinical importance |
| title_full_unstemmed | Targeting deregulated oxidative stress in skin inflammatory diseases: An update on clinical importance |
| title_short | Targeting deregulated oxidative stress in skin inflammatory diseases: An update on clinical importance |
| title_sort | Targeting deregulated oxidative stress in skin inflammatory diseases: An update on clinical importance |
| topic | Biological sciences Biochemistry and cell biology Biomedical and clinical sciences Clinical sciences Chemical sciences Medicinal and biomolecular chemistry Skin diseases Natural products Signaling mechanisms Xenobiotics and clinical challenges |