Disturbed hemodynamics and oxidative stress interaction in endothelial dysfunction and AAA progression: Focus on Nrf2 pathway
<p dir="ltr">Hemodynamic shear stress is one of the major factors that are involved in the pathogenesis of many cardiovascular diseases including atherosclerosis and abdominal aortic aneurysm (AAA), through its modulatory effect on the endothelial cell’s redox homeostasis and mechano...
محفوظ في:
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| مؤلفون آخرون: | , , , , |
| منشور في: |
2023
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إضافة وسم
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| _version_ | 1864513560185405440 |
|---|---|
| author | Maram Hasan (6672440) |
| author2 | Hassan Al-Thani (440106) Ayman El-Menyar (440103) Asad Zeidan (8879705) Asmaa Al-Thani (16855140) Huseyin C. Yalcin (6695099) |
| author2_role | author author author author author |
| author_facet | Maram Hasan (6672440) Hassan Al-Thani (440106) Ayman El-Menyar (440103) Asad Zeidan (8879705) Asmaa Al-Thani (16855140) Huseyin C. Yalcin (6695099) |
| author_role | author |
| dc.creator.none.fl_str_mv | Maram Hasan (6672440) Hassan Al-Thani (440106) Ayman El-Menyar (440103) Asad Zeidan (8879705) Asmaa Al-Thani (16855140) Huseyin C. Yalcin (6695099) |
| dc.date.none.fl_str_mv | 2023-07-31T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.ijcard.2023.131238 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Disturbed_hemodynamics_and_oxidative_stress_interaction_in_endothelial_dysfunction_and_AAA_progression_Focus_on_Nrf2_pathway/23994633 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology N0rf2 Shear stress Disturbed hemodynamics Oscillatory flow Abdominal aortic aneurysm Atherosclerosis Endothelial dysfunction Oxidative stress |
| dc.title.none.fl_str_mv | Disturbed hemodynamics and oxidative stress interaction in endothelial dysfunction and AAA progression: Focus on Nrf2 pathway |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Hemodynamic shear stress is one of the major factors that are involved in the pathogenesis of many cardiovascular diseases including atherosclerosis and abdominal aortic aneurysm (AAA), through its modulatory effect on the endothelial cell’s redox homeostasis and mechanosensitive gene expression. Among important mechanisms, oxidative stress, endoplasmic reticulum stress activation, and the subsequent endothelial dysfunction are attributed to disturbed blood flow and low shear stress in the vascular curvature and bifurcations which are considered atheroprone regions and aneurysm occurrence spots. Many pathways were shown to be involved in AAA progression. Of particular interest from recent findings is, the (Nrf2)/Keap-1 pathway, where Nrf2 is a transcription factor that has antioxidant properties and is strongly associated with several CVDs, yet, the exact mechanism by which Nrf2 alleviates CVDs still to be elucidated. Nrf2 expression is closely affected by shear stress and was shown to participate in AAA. In the current review paper, we discussed the link between disturbed hemodynamics and its effect on Nrf2 as a mechanosensitive gene and its role in the development of endothelial dysfunction which is linked to the progression of AAA.</p><h2>Other Information</h2><p dir="ltr">Published in: International Journal of Cardiology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.ijcard.2023.131238" target="_blank">https://dx.doi.org/10.1016/j.ijcard.2023.131238</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_4916c0b664784f1019cfdeebb59fe1b1 |
| identifier_str_mv | 10.1016/j.ijcard.2023.131238 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/23994633 |
| publishDate | 2023 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Disturbed hemodynamics and oxidative stress interaction in endothelial dysfunction and AAA progression: Focus on Nrf2 pathwayMaram Hasan (6672440)Hassan Al-Thani (440106)Ayman El-Menyar (440103)Asad Zeidan (8879705)Asmaa Al-Thani (16855140)Huseyin C. Yalcin (6695099)Biomedical and clinical sciencesCardiovascular medicine and haematologyN0rf2Shear stressDisturbed hemodynamicsOscillatory flowAbdominal aortic aneurysmAtherosclerosisEndothelial dysfunctionOxidative stress<p dir="ltr">Hemodynamic shear stress is one of the major factors that are involved in the pathogenesis of many cardiovascular diseases including atherosclerosis and abdominal aortic aneurysm (AAA), through its modulatory effect on the endothelial cell’s redox homeostasis and mechanosensitive gene expression. Among important mechanisms, oxidative stress, endoplasmic reticulum stress activation, and the subsequent endothelial dysfunction are attributed to disturbed blood flow and low shear stress in the vascular curvature and bifurcations which are considered atheroprone regions and aneurysm occurrence spots. Many pathways were shown to be involved in AAA progression. Of particular interest from recent findings is, the (Nrf2)/Keap-1 pathway, where Nrf2 is a transcription factor that has antioxidant properties and is strongly associated with several CVDs, yet, the exact mechanism by which Nrf2 alleviates CVDs still to be elucidated. Nrf2 expression is closely affected by shear stress and was shown to participate in AAA. In the current review paper, we discussed the link between disturbed hemodynamics and its effect on Nrf2 as a mechanosensitive gene and its role in the development of endothelial dysfunction which is linked to the progression of AAA.</p><h2>Other Information</h2><p dir="ltr">Published in: International Journal of Cardiology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.ijcard.2023.131238" target="_blank">https://dx.doi.org/10.1016/j.ijcard.2023.131238</a></p>2023-07-31T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.ijcard.2023.131238https://figshare.com/articles/journal_contribution/Disturbed_hemodynamics_and_oxidative_stress_interaction_in_endothelial_dysfunction_and_AAA_progression_Focus_on_Nrf2_pathway/23994633CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/239946332023-07-31T00:00:00Z |
| spellingShingle | Disturbed hemodynamics and oxidative stress interaction in endothelial dysfunction and AAA progression: Focus on Nrf2 pathway Maram Hasan (6672440) Biomedical and clinical sciences Cardiovascular medicine and haematology N0rf2 Shear stress Disturbed hemodynamics Oscillatory flow Abdominal aortic aneurysm Atherosclerosis Endothelial dysfunction Oxidative stress |
| status_str | publishedVersion |
| title | Disturbed hemodynamics and oxidative stress interaction in endothelial dysfunction and AAA progression: Focus on Nrf2 pathway |
| title_full | Disturbed hemodynamics and oxidative stress interaction in endothelial dysfunction and AAA progression: Focus on Nrf2 pathway |
| title_fullStr | Disturbed hemodynamics and oxidative stress interaction in endothelial dysfunction and AAA progression: Focus on Nrf2 pathway |
| title_full_unstemmed | Disturbed hemodynamics and oxidative stress interaction in endothelial dysfunction and AAA progression: Focus on Nrf2 pathway |
| title_short | Disturbed hemodynamics and oxidative stress interaction in endothelial dysfunction and AAA progression: Focus on Nrf2 pathway |
| title_sort | Disturbed hemodynamics and oxidative stress interaction in endothelial dysfunction and AAA progression: Focus on Nrf2 pathway |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology N0rf2 Shear stress Disturbed hemodynamics Oscillatory flow Abdominal aortic aneurysm Atherosclerosis Endothelial dysfunction Oxidative stress |