Venoarterial Extracorporeal MembraneOxygenation in Septic Shock and/or Sepsis-induced Cardiomyopathy: A Systematic Review of Fifteen Studies
<h3 dir="ltr">Objective(s)</h3><p dir="ltr">To evaluate survival outcomes and identify candidate profiles for venoarterial extracorporeal membrane oxygenation in adult patients with sepsis-induced cardiomyopathy. </p><h3 dir="ltr">Design<...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , |
| منشور في: |
2025
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513524080836608 |
|---|---|
| author | Ans Alamami (14777233) |
| author2 | Alaa Rahhal (14150403) Rabee Tawel (21363629) Munsef Barakat (17563266) Mohammed Salah Abdelghani (23073847) Abdurrahmaan Elbuzidi (23073850) Ahmed Labib Shehatta (17347069) Amr Salah Omar (23073853) |
| author2_role | author author author author author author author |
| author_facet | Ans Alamami (14777233) Alaa Rahhal (14150403) Rabee Tawel (21363629) Munsef Barakat (17563266) Mohammed Salah Abdelghani (23073847) Abdurrahmaan Elbuzidi (23073850) Ahmed Labib Shehatta (17347069) Amr Salah Omar (23073853) |
| author_role | author |
| dc.creator.none.fl_str_mv | Ans Alamami (14777233) Alaa Rahhal (14150403) Rabee Tawel (21363629) Munsef Barakat (17563266) Mohammed Salah Abdelghani (23073847) Abdurrahmaan Elbuzidi (23073850) Ahmed Labib Shehatta (17347069) Amr Salah Omar (23073853) |
| dc.date.none.fl_str_mv | 2025-10-02T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1053/j.jvca.2025.09.237 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Venoarterial_Extracorporeal_MembraneOxygenation_in_Septic_Shock_and_or_Sepsis-induced_Cardiomyopathy_A_Systematic_Review_of_Fifteen_Studies/31169386 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Sepsis-induced cardiomyopathy Septic shock Critical care Intensive care unit (ICU) Hemodynamic instability |
| dc.title.none.fl_str_mv | Venoarterial Extracorporeal MembraneOxygenation in Septic Shock and/or Sepsis-induced Cardiomyopathy: A Systematic Review of Fifteen Studies |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3 dir="ltr">Objective(s)</h3><p dir="ltr">To evaluate survival outcomes and identify candidate profiles for venoarterial extracorporeal membrane oxygenation in adult patients with sepsis-induced cardiomyopathy. </p><h3 dir="ltr">Design</h3><p dir="ltr">The authors systematically searched PubMed, Embase, and Google Scholar up to October 22, 2024, for English-language studies investigating venoarterial extracorporeal membrane oxygenation in adult patients with septic shock and/or sepsis-induced cardiomyopathy. Two reviewers independently screened studies, assessed quality, and extracted data on demographics, illness severity, and survival. </p><h3 dir="ltr">Setting</h3><p dir="ltr">Studies were conducted in intensive care units across multiple international centers. </p><h3 dir="ltr">Participants</h3><p dir="ltr">A total of 15 studies, including 1,110 adult patients with septic shock and/or septic cardiomyopathy who underwent extracorporeal membrane oxygenation support, were identified. </p><h3 dir="ltr">Interventions</h3><p dir="ltr">Venoarterial extracorporeal membrane oxygenation was implemented as a salvage therapy for refractory septic shock and/or sepsis-induced cardiomyopathy. </p><h3 dir="ltr">Measurements and Main Results</h3><p dir="ltr">The primary outcome was survival to hospital discharge. Secondary data included age, mean arterial pressure, arterial pH, lactate level, PaO₂/FiO₂ ratio, ejection fraction, inotrope score, and Sequential Organ Failure Assessment (SOFA) score. The pooled survival rate was 42%. At venoarterial extracorporeal membrane oxygenation initiation, patients exhibited severe hemodynamic instability: mean age 52 ± 6 years; mean arterial pressure 62 ± 8 mmHg; pH 7.20 ± 0.07; lactate 9 ± 6 mmol/L; PaO₂/FiO₂ 85 ± 20; ejection fraction 33% ± 15; inotrope score 122 ± 99 μg/kg/min; SOFA score 15 ± 3. </p><h3 dir="ltr">Conclusions</h3><p dir="ltr">Venoarterial extracorporeal membrane oxygenation may provide meaningful survival benefits in carefully selected patients with severe, refractory septic shock and/or sepsis-induced cardiomyopathy. Given the observational nature and the heterogeneity of the included studies, these findings should be interpreted with caution. Further prospective trials are needed to refine patient selection and optimize outcomes.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Journal of Cardiothoracic and Vascular Anesthesia<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1053/j.jvca.2025.09.237" target="_blank">https://dx.doi.org/10.1053/j.jvca.2025.09.237</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_49aa322e805709e755d5c17d29521a8a |
| identifier_str_mv | 10.1053/j.jvca.2025.09.237 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/31169386 |
| publishDate | 2025 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Venoarterial Extracorporeal MembraneOxygenation in Septic Shock and/or Sepsis-induced Cardiomyopathy: A Systematic Review of Fifteen StudiesAns Alamami (14777233)Alaa Rahhal (14150403)Rabee Tawel (21363629)Munsef Barakat (17563266)Mohammed Salah Abdelghani (23073847)Abdurrahmaan Elbuzidi (23073850)Ahmed Labib Shehatta (17347069)Amr Salah Omar (23073853)Biomedical and clinical sciencesCardiovascular medicine and haematologyClinical sciencesSepsis-induced cardiomyopathySeptic shockCritical careIntensive care unit (ICU)Hemodynamic instability<h3 dir="ltr">Objective(s)</h3><p dir="ltr">To evaluate survival outcomes and identify candidate profiles for venoarterial extracorporeal membrane oxygenation in adult patients with sepsis-induced cardiomyopathy. </p><h3 dir="ltr">Design</h3><p dir="ltr">The authors systematically searched PubMed, Embase, and Google Scholar up to October 22, 2024, for English-language studies investigating venoarterial extracorporeal membrane oxygenation in adult patients with septic shock and/or sepsis-induced cardiomyopathy. Two reviewers independently screened studies, assessed quality, and extracted data on demographics, illness severity, and survival. </p><h3 dir="ltr">Setting</h3><p dir="ltr">Studies were conducted in intensive care units across multiple international centers. </p><h3 dir="ltr">Participants</h3><p dir="ltr">A total of 15 studies, including 1,110 adult patients with septic shock and/or septic cardiomyopathy who underwent extracorporeal membrane oxygenation support, were identified. </p><h3 dir="ltr">Interventions</h3><p dir="ltr">Venoarterial extracorporeal membrane oxygenation was implemented as a salvage therapy for refractory septic shock and/or sepsis-induced cardiomyopathy. </p><h3 dir="ltr">Measurements and Main Results</h3><p dir="ltr">The primary outcome was survival to hospital discharge. Secondary data included age, mean arterial pressure, arterial pH, lactate level, PaO₂/FiO₂ ratio, ejection fraction, inotrope score, and Sequential Organ Failure Assessment (SOFA) score. The pooled survival rate was 42%. At venoarterial extracorporeal membrane oxygenation initiation, patients exhibited severe hemodynamic instability: mean age 52 ± 6 years; mean arterial pressure 62 ± 8 mmHg; pH 7.20 ± 0.07; lactate 9 ± 6 mmol/L; PaO₂/FiO₂ 85 ± 20; ejection fraction 33% ± 15; inotrope score 122 ± 99 μg/kg/min; SOFA score 15 ± 3. </p><h3 dir="ltr">Conclusions</h3><p dir="ltr">Venoarterial extracorporeal membrane oxygenation may provide meaningful survival benefits in carefully selected patients with severe, refractory septic shock and/or sepsis-induced cardiomyopathy. Given the observational nature and the heterogeneity of the included studies, these findings should be interpreted with caution. Further prospective trials are needed to refine patient selection and optimize outcomes.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Journal of Cardiothoracic and Vascular Anesthesia<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1053/j.jvca.2025.09.237" target="_blank">https://dx.doi.org/10.1053/j.jvca.2025.09.237</a></p>2025-10-02T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1053/j.jvca.2025.09.237https://figshare.com/articles/journal_contribution/Venoarterial_Extracorporeal_MembraneOxygenation_in_Septic_Shock_and_or_Sepsis-induced_Cardiomyopathy_A_Systematic_Review_of_Fifteen_Studies/31169386CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/311693862025-10-02T03:00:00Z |
| spellingShingle | Venoarterial Extracorporeal MembraneOxygenation in Septic Shock and/or Sepsis-induced Cardiomyopathy: A Systematic Review of Fifteen Studies Ans Alamami (14777233) Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Sepsis-induced cardiomyopathy Septic shock Critical care Intensive care unit (ICU) Hemodynamic instability |
| status_str | publishedVersion |
| title | Venoarterial Extracorporeal MembraneOxygenation in Septic Shock and/or Sepsis-induced Cardiomyopathy: A Systematic Review of Fifteen Studies |
| title_full | Venoarterial Extracorporeal MembraneOxygenation in Septic Shock and/or Sepsis-induced Cardiomyopathy: A Systematic Review of Fifteen Studies |
| title_fullStr | Venoarterial Extracorporeal MembraneOxygenation in Septic Shock and/or Sepsis-induced Cardiomyopathy: A Systematic Review of Fifteen Studies |
| title_full_unstemmed | Venoarterial Extracorporeal MembraneOxygenation in Septic Shock and/or Sepsis-induced Cardiomyopathy: A Systematic Review of Fifteen Studies |
| title_short | Venoarterial Extracorporeal MembraneOxygenation in Septic Shock and/or Sepsis-induced Cardiomyopathy: A Systematic Review of Fifteen Studies |
| title_sort | Venoarterial Extracorporeal MembraneOxygenation in Septic Shock and/or Sepsis-induced Cardiomyopathy: A Systematic Review of Fifteen Studies |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Clinical sciences Sepsis-induced cardiomyopathy Septic shock Critical care Intensive care unit (ICU) Hemodynamic instability |