10-Day structured initiation protocol from multiple daily injection to hybrid closed-loop system in children and adolescents with type 1 diabetes
<h3>Aim</h3><p dir="ltr">The aim of this study was to evaluate the 10-day initiation protocol for MiniMed 670G hybrid closed-loop (HCL) system in individuals with type 1 diabetes on multiple daily injection (MDI) in achieving desirable glycemic control.</p><h3>...
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2020
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| _version_ | 1864513567979470848 |
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| author | Goran Petrovski (129836) |
| author2 | Fawziya Al Khalaf (9303667) Judith Campbell (5496704) Hannah Fisher (14150685) Fareeda Umer (14150688) Khalid Hussain (110443) |
| author2_role | author author author author author |
| author_facet | Goran Petrovski (129836) Fawziya Al Khalaf (9303667) Judith Campbell (5496704) Hannah Fisher (14150685) Fareeda Umer (14150688) Khalid Hussain (110443) |
| author_role | author |
| dc.creator.none.fl_str_mv | Goran Petrovski (129836) Fawziya Al Khalaf (9303667) Judith Campbell (5496704) Hannah Fisher (14150685) Fareeda Umer (14150688) Khalid Hussain (110443) |
| dc.date.none.fl_str_mv | 2020-01-17T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s00592-019-01472-w |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/10-Day_structured_initiation_protocol_from_multiple_daily_injection_to_hybrid_closed-loop_system_in_children_and_adolescents_with_type_1_diabetes/21597102 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Hybrid closed-loop system Multiple daily injection Protocol Type 1 diabetes |
| dc.title.none.fl_str_mv | 10-Day structured initiation protocol from multiple daily injection to hybrid closed-loop system in children and adolescents with type 1 diabetes |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Aim</h3><p dir="ltr">The aim of this study was to evaluate the 10-day initiation protocol for MiniMed 670G hybrid closed-loop (HCL) system in individuals with type 1 diabetes on multiple daily injection (MDI) in achieving desirable glycemic control.</p><h3>Methods</h3><p dir="ltr">An open-label single-arm, single-center, clinical investigation in children aged 7–18 years on MDI following a structured protocol: 2 days, HCL system assessment; 5 days, HCL system training (2-h sessions on 5 consecutive days with groups of 3–5 participants and families); 3 days, Manual Mode use of HCL system; 84 days, Auto Mode use of the HCL system, cumulating in 10 days from MDI to Auto Mode activation.</p><h3>Results</h3><p dir="ltr">A total of 30 children (age 10.24 ± 2.6 years) were enrolled in the study, and all completed the planned 84 days on Auto Mode. The participants used the sensor for a median of 92% of the time and spent a median of 89% in Auto Mode. The mean HbA1c decreased from 8.2 ± 1.4% (66 ± 15.3 mmol/mol) at baseline to 6.7 ± 0.5% (50 ± 5.5 mmol/mol) at the end of the study (p = 0.017). Time in range (70–180 mg/dL) increased from 46.9 ± 18.5% at baseline to 75.6 ± 6.9% in Auto Mode (p < 0.001). This was achieved while spending 2.8% of the time below 70 mg/dL and without any severe hypoglycemia or DKA.</p><h3>Conclusion</h3><p dir="ltr">Children and adolescents with type 1 diabetes on MDI therapy can successfully initiate the HCL system, using a concise structured 10-day protocol.</p><h2>Other Information</h2><p dir="ltr">Published in: Acta Diabetologica<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s00592-019-01472-w" target="_blank">http://dx.doi.org/10.1007/s00592-019-01472-w</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_49beedc87898df670c61fd85c242fbfd |
| identifier_str_mv | 10.1007/s00592-019-01472-w |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21597102 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | 10-Day structured initiation protocol from multiple daily injection to hybrid closed-loop system in children and adolescents with type 1 diabetesGoran Petrovski (129836)Fawziya Al Khalaf (9303667)Judith Campbell (5496704)Hannah Fisher (14150685)Fareeda Umer (14150688)Khalid Hussain (110443)Biomedical and clinical sciencesClinical sciencesHybrid closed-loop systemMultiple daily injectionProtocolType 1 diabetes<h3>Aim</h3><p dir="ltr">The aim of this study was to evaluate the 10-day initiation protocol for MiniMed 670G hybrid closed-loop (HCL) system in individuals with type 1 diabetes on multiple daily injection (MDI) in achieving desirable glycemic control.</p><h3>Methods</h3><p dir="ltr">An open-label single-arm, single-center, clinical investigation in children aged 7–18 years on MDI following a structured protocol: 2 days, HCL system assessment; 5 days, HCL system training (2-h sessions on 5 consecutive days with groups of 3–5 participants and families); 3 days, Manual Mode use of HCL system; 84 days, Auto Mode use of the HCL system, cumulating in 10 days from MDI to Auto Mode activation.</p><h3>Results</h3><p dir="ltr">A total of 30 children (age 10.24 ± 2.6 years) were enrolled in the study, and all completed the planned 84 days on Auto Mode. The participants used the sensor for a median of 92% of the time and spent a median of 89% in Auto Mode. The mean HbA1c decreased from 8.2 ± 1.4% (66 ± 15.3 mmol/mol) at baseline to 6.7 ± 0.5% (50 ± 5.5 mmol/mol) at the end of the study (p = 0.017). Time in range (70–180 mg/dL) increased from 46.9 ± 18.5% at baseline to 75.6 ± 6.9% in Auto Mode (p < 0.001). This was achieved while spending 2.8% of the time below 70 mg/dL and without any severe hypoglycemia or DKA.</p><h3>Conclusion</h3><p dir="ltr">Children and adolescents with type 1 diabetes on MDI therapy can successfully initiate the HCL system, using a concise structured 10-day protocol.</p><h2>Other Information</h2><p dir="ltr">Published in: Acta Diabetologica<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s00592-019-01472-w" target="_blank">http://dx.doi.org/10.1007/s00592-019-01472-w</a></p>2020-01-17T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s00592-019-01472-whttps://figshare.com/articles/journal_contribution/10-Day_structured_initiation_protocol_from_multiple_daily_injection_to_hybrid_closed-loop_system_in_children_and_adolescents_with_type_1_diabetes/21597102CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215971022020-01-17T06:00:00Z |
| spellingShingle | 10-Day structured initiation protocol from multiple daily injection to hybrid closed-loop system in children and adolescents with type 1 diabetes Goran Petrovski (129836) Biomedical and clinical sciences Clinical sciences Hybrid closed-loop system Multiple daily injection Protocol Type 1 diabetes |
| status_str | publishedVersion |
| title | 10-Day structured initiation protocol from multiple daily injection to hybrid closed-loop system in children and adolescents with type 1 diabetes |
| title_full | 10-Day structured initiation protocol from multiple daily injection to hybrid closed-loop system in children and adolescents with type 1 diabetes |
| title_fullStr | 10-Day structured initiation protocol from multiple daily injection to hybrid closed-loop system in children and adolescents with type 1 diabetes |
| title_full_unstemmed | 10-Day structured initiation protocol from multiple daily injection to hybrid closed-loop system in children and adolescents with type 1 diabetes |
| title_short | 10-Day structured initiation protocol from multiple daily injection to hybrid closed-loop system in children and adolescents with type 1 diabetes |
| title_sort | 10-Day structured initiation protocol from multiple daily injection to hybrid closed-loop system in children and adolescents with type 1 diabetes |
| topic | Biomedical and clinical sciences Clinical sciences Hybrid closed-loop system Multiple daily injection Protocol Type 1 diabetes |