Are platelet indices useful in diagnosis of tropical acute febrile illnesses?
<h3 dir="ltr">Background</h3><p dir="ltr">Diagnosis and treatment of tropical acute febrile illnesses is challenging with respect to health facilities and personnel and diagnostic kits. Platelet indices are available at no extra cost or blood requirements. They...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | |
| منشور في: |
2016
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513522626461696 |
|---|---|
| author | Stalin Viswanathan (422195) |
| author2 | Vijayakumar Saravanakumari (19807287) |
| author2_role | author |
| author_facet | Stalin Viswanathan (422195) Vijayakumar Saravanakumari (19807287) |
| author_role | author |
| dc.creator.none.fl_str_mv | Stalin Viswanathan (422195) Vijayakumar Saravanakumari (19807287) |
| dc.date.none.fl_str_mv | 2016-06-18T12:00:00Z |
| dc.identifier.none.fl_str_mv | 10.5339/jlghs.2016.3 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Are_platelet_indices_useful_in_diagnosis_of_tropical_acute_febrile_illnesses_/27175527 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Health sciences Public health platelet indices acute febrile illness infections fever tropics |
| dc.title.none.fl_str_mv | Are platelet indices useful in diagnosis of tropical acute febrile illnesses? |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3 dir="ltr">Background</h3><p dir="ltr">Diagnosis and treatment of tropical acute febrile illnesses is challenging with respect to health facilities and personnel and diagnostic kits. Platelet indices are available at no extra cost or blood requirements. They are useful in diagnosing both infective and non-infective diseases. However, these indices have not been used previously to predict the differential diagnosis of common tropical febrile illnesses using a decision tree.</p><h3 dir="ltr">Methods</h3><p dir="ltr">A retrospective analysis of clinical and laboratory data of 402 patients with fever lasting for >24 h and < 3 weeks was performed. Subjects were divided into seven diagnostic groups: bacterial, viral, rickettsial, parasitic, mycobacterial, undifferentiated, and non-infective. Bivariate correlation and distribution of platelet indices among the diagnostic groups were examined. The area under the curve was obtained using these indices for each group. A classification tree was also constructed with these indices and other variables sequentially, to predict the likely cause of the fever.</p><h3 dir="ltr">Results</h3><p dir="ltr">Subjects were predominantly males (255) and young individuals (242). The most common causes of fever were viral (18.2%) and bacterial (16.8%) infections. Platelet indices varied significantly across all the groups, even after controlling for other clinical/laboratory parameters. Receiver-operating characteristic analysis showed that high platelet count had the best sensitivity and specificity for diagnosis of tuberculosis. The classification tree constructed using platelet indices alone had a higher margin of error than that using a combination of clinical symptoms, complete blood count, liver function tests, and ECG heart rate.</p><h3 dir="ltr">Conclusions</h3><p dir="ltr">Platelet indices vary significantly across tropical illnesses. Thrombocytosis has good sensitivity and specificity for diagnosis of tuberculosis. Combined with clinical symptoms and routine blood tests, these indices predicted a likely diagnosis in two-thirds of patients. Prospective validation in different localities is needed prior to the use of these indices in the diagnosis of acute febrile illnesses.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Journal of Local and Global Health Science, title discontinued as of (2017)<br>License: <a href="https://creativecommons.org/licenses/by/4.0/deed.en" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.5339/jlghs.2016.3" target="_blank">https://dx.doi.org/10.5339/jlghs.2016.3</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_4a49766a27cc1f95315feb172f8cb80c |
| identifier_str_mv | 10.5339/jlghs.2016.3 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/27175527 |
| publishDate | 2016 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Are platelet indices useful in diagnosis of tropical acute febrile illnesses?Stalin Viswanathan (422195)Vijayakumar Saravanakumari (19807287)Biomedical and clinical sciencesClinical sciencesHealth sciencesPublic healthplatelet indicesacute febrile illnessinfectionsfevertropics<h3 dir="ltr">Background</h3><p dir="ltr">Diagnosis and treatment of tropical acute febrile illnesses is challenging with respect to health facilities and personnel and diagnostic kits. Platelet indices are available at no extra cost or blood requirements. They are useful in diagnosing both infective and non-infective diseases. However, these indices have not been used previously to predict the differential diagnosis of common tropical febrile illnesses using a decision tree.</p><h3 dir="ltr">Methods</h3><p dir="ltr">A retrospective analysis of clinical and laboratory data of 402 patients with fever lasting for >24 h and < 3 weeks was performed. Subjects were divided into seven diagnostic groups: bacterial, viral, rickettsial, parasitic, mycobacterial, undifferentiated, and non-infective. Bivariate correlation and distribution of platelet indices among the diagnostic groups were examined. The area under the curve was obtained using these indices for each group. A classification tree was also constructed with these indices and other variables sequentially, to predict the likely cause of the fever.</p><h3 dir="ltr">Results</h3><p dir="ltr">Subjects were predominantly males (255) and young individuals (242). The most common causes of fever were viral (18.2%) and bacterial (16.8%) infections. Platelet indices varied significantly across all the groups, even after controlling for other clinical/laboratory parameters. Receiver-operating characteristic analysis showed that high platelet count had the best sensitivity and specificity for diagnosis of tuberculosis. The classification tree constructed using platelet indices alone had a higher margin of error than that using a combination of clinical symptoms, complete blood count, liver function tests, and ECG heart rate.</p><h3 dir="ltr">Conclusions</h3><p dir="ltr">Platelet indices vary significantly across tropical illnesses. Thrombocytosis has good sensitivity and specificity for diagnosis of tuberculosis. Combined with clinical symptoms and routine blood tests, these indices predicted a likely diagnosis in two-thirds of patients. Prospective validation in different localities is needed prior to the use of these indices in the diagnosis of acute febrile illnesses.</p><h2 dir="ltr">Other Information</h2><p dir="ltr">Published in: Journal of Local and Global Health Science, title discontinued as of (2017)<br>License: <a href="https://creativecommons.org/licenses/by/4.0/deed.en" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.5339/jlghs.2016.3" target="_blank">https://dx.doi.org/10.5339/jlghs.2016.3</a></p>2016-06-18T12:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.5339/jlghs.2016.3https://figshare.com/articles/journal_contribution/Are_platelet_indices_useful_in_diagnosis_of_tropical_acute_febrile_illnesses_/27175527CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/271755272016-06-18T12:00:00Z |
| spellingShingle | Are platelet indices useful in diagnosis of tropical acute febrile illnesses? Stalin Viswanathan (422195) Biomedical and clinical sciences Clinical sciences Health sciences Public health platelet indices acute febrile illness infections fever tropics |
| status_str | publishedVersion |
| title | Are platelet indices useful in diagnosis of tropical acute febrile illnesses? |
| title_full | Are platelet indices useful in diagnosis of tropical acute febrile illnesses? |
| title_fullStr | Are platelet indices useful in diagnosis of tropical acute febrile illnesses? |
| title_full_unstemmed | Are platelet indices useful in diagnosis of tropical acute febrile illnesses? |
| title_short | Are platelet indices useful in diagnosis of tropical acute febrile illnesses? |
| title_sort | Are platelet indices useful in diagnosis of tropical acute febrile illnesses? |
| topic | Biomedical and clinical sciences Clinical sciences Health sciences Public health platelet indices acute febrile illness infections fever tropics |