Intratumoral FoxP3<sup>+</sup>Helios<sup>+</sup> Regulatory T Cells Upregulating Immunosuppressive Molecules Are Expanded in Human Colorectal Cancer

Intratumoral FoxP3<sup>+</sup>Helios<sup>+</sup> Regulatory T Cells Upregulating Immunosuppressive Molecules Are Expanded in Human Colorectal Cancer

<p dir="ltr">Regulatory T cells (Tregs) can be antitumorigenic or pro-tumorigenic in colorectal cancer (CRC) depending on the presence of different Treg subsets with various immunosuppressive molecules. Some studies reported the phenotypic characteristics of tumor-infiltrating immune...

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Bibliographic Details
Main Author: Azharuddin Sajid Syed Khaja (19720114) (author)
Other Authors: Salman M. Toor (8854751) (author), Haytham El Salhat (5396387) (author), Bassam R. Ali (8711034) (author), Eyad Elkord (5396390) (author)
Published: 2017
Subjects:
Biomedical and clinical sciences
Immunology
Oncology and carcinogenesis
colorectal cancer
regulatory T cells
Forkhead box protein
Helios
immune checkpoint receptors
tumor microenvironment
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