Author Correction: CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer

Author Correction: CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer

<p dir="ltr"><br>Correction to: CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer. <a href="https://dx.doi.org/10.1038/s41467-019-13105-5" target="_blank">https://dx.doi.org/10.1038/s41467-019-13105-...

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Main Author: Lei Nie (556344) (author)
Other Authors: Yongkun Wei (9694532) (author), Fei Zhang (85787) (author), Yi-Hsin Hsu (14917341) (author), Li-Chuan Chan (14917344) (author), Weiya Xia (454357) (author), Baozhen Ke (18614872) (author), Cihui Zhu (14894885) (author), Rong Deng (137189) (author), Jun Tang (32983) (author), Jun Yao (9646) (author), Yu-Yi Chu (636524) (author), Xixi Zhao (4251673) (author), Ye Han (261096) (author), Junwei Hou (2793103) (author), Longfei Huo (361824) (author), How-Wen Ko (10852734) (author), Wan-Chi Lin (313304) (author), Hirohito Yamaguchi (14884460) (author), Jung-Mao Hsu (14889527) (author), Yi Yang (116183) (author), Dean N. Pan (18208070) (author), Jennifer L. Hsu (245027) (author), Celina G. Kleer (14683138) (author), Nancy E. Davidson (463811) (author), Gabriel N. Hortobagyi (14888835) (author), Mien-Chie Hung (102628) (author)
Published: 2020
Subjects:
Biomedical and clinical sciences
Clinical sciences
Oncology and carcinogenesis
Triple-negative breast cancer (TNBC)
Estrogen receptor α (ERα)
Progesterone receptor
Human epidermal growth factor receptor 2 (HER2)
Basal-like breast cancer
Cyclin E
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Summary:<p dir="ltr"><br>Correction to: CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer. <a href="https://dx.doi.org/10.1038/s41467-019-13105-5" target="_blank">https://dx.doi.org/10.1038/s41467-019-13105-5</a> published online 08 November 2022.</p><p dir="ltr"><br>Triple-negative breast cancer (TNBC), which lacks estrogen receptor α (ERα), progesterone receptor, and human epidermal growth factor receptor 2 (HER2) expression, is closely related to basal-like breast cancer. Previously, we and others report that cyclin E/cyclin-dependent kinase 2 (CDK2) phosphorylates enhancer of zeste homolog 2 (EZH2) at T416 (pT416-EZH2). Here, we show that transgenic expression of phospho-mimicking EZH2 mutant EZH2T416D in mammary glands leads to tumors with TNBC phenotype. Coexpression of EZH2<sup>T416D</sup> in mammary epithelia of HER2/Neu transgenic mice reprograms HER2-driven luminal tumors into basal-like tumors. Pharmacological inhibition of CDK2 or EZH2 allows re-expression of ERα and converts TNBC to luminal ERα-positive, rendering TNBC cells targetable by tamoxifen. Furthermore, the combination of either CDK2 or EZH2 inhibitor with tamoxifen effectively suppresses tumor growth and markedly improves the survival of the mice bearing TNBC tumors, suggesting that the mechanism-based combination therapy may be an alternative approach to treat TNBC.</p><h2>Other Information</h2><p dir="ltr">Published in: Nature Communications<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1038/s41467-020-14429-3" target="_blank">https://dx.doi.org/10.1038/s41467-020-14429-3</a></p>

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