Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection?
<h3>Background</h3><p dir="ltr">Women with polycystic ovary syndrome (PCOS) often have vitamin D deficiency, a known risk factor for severe COVID-19 disease. Alveolar macrophage-derived cytokines contribute to the inflammation underlying pulmonary disease in COVID-19. We...
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| مؤلفون آخرون: | , , |
| منشور في: |
2021
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| _version_ | 1864513515345149952 |
|---|---|
| author | Abu Saleh Md Moin (6189512) |
| author2 | Thozhukat Sathyapalan (704787) Alexandra E. Butler (6189536) Stephen L. Atkin (6684368) |
| author2_role | author author author |
| author_facet | Abu Saleh Md Moin (6189512) Thozhukat Sathyapalan (704787) Alexandra E. Butler (6189536) Stephen L. Atkin (6684368) |
| author_role | author |
| dc.creator.none.fl_str_mv | Abu Saleh Md Moin (6189512) Thozhukat Sathyapalan (704787) Alexandra E. Butler (6189536) Stephen L. Atkin (6684368) |
| dc.date.none.fl_str_mv | 2021-02-25T03:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3389/fendo.2021.638621 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Vitamin_D_Association_With_Macrophage-Derived_Cytokines_in_Polycystic_Ovary_Syndrome_An_Enhanced_Risk_of_COVID-19_Infection_/25867675 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Clinical sciences Immunology COVID-19 risk factors polycystic ovary disease vitamin D macrophage cytokines |
| dc.title.none.fl_str_mv | Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection? |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <h3>Background</h3><p dir="ltr">Women with polycystic ovary syndrome (PCOS) often have vitamin D deficiency, a known risk factor for severe COVID-19 disease. Alveolar macrophage-derived cytokines contribute to the inflammation underlying pulmonary disease in COVID-19. We sought to determine if basal macrophage activation, as a risk factor for COVID-19 infection, was present in PCOS and, if so, was further enhanced by vitamin D deficiency.</p><h3>Methods</h3><p dir="ltr">A cross-sectional study in 99 PCOS and 68 control women who presented sequentially. Plasma levels of a macrophage-derived cytokine panel were determined by Slow Off-rate Modified Aptamer (SOMA)-scan plasma protein measurement. Vitamin D was measured by tandem mass spectroscopy.</p><h3>Results</h3><p dir="ltr">Vitamin D was lower in PCOS women (p<0.0001) and correlated negatively with body mass index (BMI) in PCOS (r=0.28, p=0.0046). Basal macrophage activation markers CXCL5, CD163 and MMP9 were elevated, whilst protective CD200 was decreased (p<0.05); changes in these variables were related to, and fully accounted for, by BMI. PCOS and control women were then stratified according to vitamin D concentration. Vitamin D deficiency was associated with decreased CD80 and IFN-γ in PCOS and IL-12 in both groups (p<0.05). These factors, important in initiating and maintaining the immune response, were again accounted for by BMI.</p><h3>Conclusion</h3><p dir="ltr">Basal macrophage activation was higher in PCOS with macrophage changes related with increased infection risk associating with vitamin D; all changes were BMI dependent, suggesting that obese PCOS with vitamin D deficiency may be at greater risk of more severe COVID-19 infection, but that it is obesity-related rather than an independent PCOS factor.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Endocrinology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fendo.2021.638621" target="_blank">https://dx.doi.org/10.3389/fendo.2021.638621</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_4dae41530c23e91614f20eec16c9a7ea |
| identifier_str_mv | 10.3389/fendo.2021.638621 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25867675 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection?Abu Saleh Md Moin (6189512)Thozhukat Sathyapalan (704787)Alexandra E. Butler (6189536)Stephen L. Atkin (6684368)Biomedical and clinical sciencesClinical sciencesImmunologyCOVID-19 risk factorspolycystic ovary diseasevitamin Dmacrophagecytokines<h3>Background</h3><p dir="ltr">Women with polycystic ovary syndrome (PCOS) often have vitamin D deficiency, a known risk factor for severe COVID-19 disease. Alveolar macrophage-derived cytokines contribute to the inflammation underlying pulmonary disease in COVID-19. We sought to determine if basal macrophage activation, as a risk factor for COVID-19 infection, was present in PCOS and, if so, was further enhanced by vitamin D deficiency.</p><h3>Methods</h3><p dir="ltr">A cross-sectional study in 99 PCOS and 68 control women who presented sequentially. Plasma levels of a macrophage-derived cytokine panel were determined by Slow Off-rate Modified Aptamer (SOMA)-scan plasma protein measurement. Vitamin D was measured by tandem mass spectroscopy.</p><h3>Results</h3><p dir="ltr">Vitamin D was lower in PCOS women (p<0.0001) and correlated negatively with body mass index (BMI) in PCOS (r=0.28, p=0.0046). Basal macrophage activation markers CXCL5, CD163 and MMP9 were elevated, whilst protective CD200 was decreased (p<0.05); changes in these variables were related to, and fully accounted for, by BMI. PCOS and control women were then stratified according to vitamin D concentration. Vitamin D deficiency was associated with decreased CD80 and IFN-γ in PCOS and IL-12 in both groups (p<0.05). These factors, important in initiating and maintaining the immune response, were again accounted for by BMI.</p><h3>Conclusion</h3><p dir="ltr">Basal macrophage activation was higher in PCOS with macrophage changes related with increased infection risk associating with vitamin D; all changes were BMI dependent, suggesting that obese PCOS with vitamin D deficiency may be at greater risk of more severe COVID-19 infection, but that it is obesity-related rather than an independent PCOS factor.</p><h2>Other Information</h2><p dir="ltr">Published in: Frontiers in Endocrinology<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.3389/fendo.2021.638621" target="_blank">https://dx.doi.org/10.3389/fendo.2021.638621</a></p>2021-02-25T03:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3389/fendo.2021.638621https://figshare.com/articles/journal_contribution/Vitamin_D_Association_With_Macrophage-Derived_Cytokines_in_Polycystic_Ovary_Syndrome_An_Enhanced_Risk_of_COVID-19_Infection_/25867675CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/258676752021-02-25T03:00:00Z |
| spellingShingle | Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection? Abu Saleh Md Moin (6189512) Biomedical and clinical sciences Clinical sciences Immunology COVID-19 risk factors polycystic ovary disease vitamin D macrophage cytokines |
| status_str | publishedVersion |
| title | Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection? |
| title_full | Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection? |
| title_fullStr | Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection? |
| title_full_unstemmed | Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection? |
| title_short | Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection? |
| title_sort | Vitamin D Association With Macrophage-Derived Cytokines in Polycystic Ovary Syndrome: An Enhanced Risk of COVID-19 Infection? |
| topic | Biomedical and clinical sciences Clinical sciences Immunology COVID-19 risk factors polycystic ovary disease vitamin D macrophage cytokines |