Cadmium-induced endothelial dysfunction mediated by asymmetric dimethylarginine
<p dir="ltr">Cadmium (Cd) is a naturally occurring toxic heavy metal with no known essential biological functions. Exposure to Cd increases the risk of cardiovascular disease by disrupting vascular homeostasis at the endothelium. The aim of the study was to evaluate the effect of chr...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | |
| منشور في: |
2020
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| الموضوعات: | |
| الوسوم: |
إضافة وسم
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| _version_ | 1864513567485591552 |
|---|---|
| author | Hamda A. Al-Naemi (14151675) |
| author2 | Sandra Concepcion Das (14151678) |
| author2_role | author |
| author_facet | Hamda A. Al-Naemi (14151675) Sandra Concepcion Das (14151678) |
| author_role | author |
| dc.creator.none.fl_str_mv | Hamda A. Al-Naemi (14151675) Sandra Concepcion Das (14151678) |
| dc.date.none.fl_str_mv | 2020-03-02T18:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1007/s11356-020-08116-5 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Cadmium-induced_endothelial_dysfunction_mediated_by_asymmetric_dimethylarginine/21597543 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Cardiovascular medicine and haematology Pharmacology and pharmaceutical sciences Environmental engineering Pollution and contamination Endothelial nitric oxide synthase (eNOS) Asymmetric dimethylarginine (ADMA) Cadmium Endothelial dysfunction |
| dc.title.none.fl_str_mv | Cadmium-induced endothelial dysfunction mediated by asymmetric dimethylarginine |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Cadmium (Cd) is a naturally occurring toxic heavy metal with no known essential biological functions. Exposure to Cd increases the risk of cardiovascular disease by disrupting vascular homeostasis at the endothelium. The aim of the study was to evaluate the effect of chronic low-dose Cd on vascular structure and function. Fifty adult male Sprague Dawley rats were grouped and assigned to one of two treatments for 14 weeks. The control group received normal water for 14 weeks while the Cd-treated group received 15 mg Cd/kg B.W. as CdCl<sub>2</sub> in water for 10 weeks. A subset of the Cd-treated group received 15 mg Cd/kg B.W. as CdCl<sub>2</sub> in water for 10 weeks followed by 4 weeks of normal water. Results show an overall decline in vascular function and structure. Withdrawal of Cd treatment showed a considerable restoration of vascular structure and vasorelaxation function. Additionally, asymmetric dimethylarginine (ADMA) bioavailability was found to be lowered over time. Interestingly, the expression of eNOS in the Cd-treated group was found to be significantly elevated during the exposure by more than 3-fold in comparison with that in the control group. This protein expression was similar to the control group after the withdrawal of Cd treatment. Taken together, the results suggest that ADMA, an eNOS inhibitor, may play a role in altering endothelial function in the presence of cadmium. In conclusion, the findings indicate that even at low doses, Cd leads to endothelial dysfunction mediated by ADMA.</p><h2>Other Information</h2><p dir="ltr">Published in: Environmental Science and Pollution Research<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s11356-020-08116-5" target="_blank">http://dx.doi.org/10.1007/s11356-020-08116-5</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_4ef4d124681812084ef59e452e4e1ed7 |
| identifier_str_mv | 10.1007/s11356-020-08116-5 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/21597543 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Cadmium-induced endothelial dysfunction mediated by asymmetric dimethylarginineHamda A. Al-Naemi (14151675)Sandra Concepcion Das (14151678)Biomedical and clinical sciencesCardiovascular medicine and haematologyPharmacology and pharmaceutical sciencesEnvironmental engineeringPollution and contaminationEndothelial nitric oxide synthase (eNOS)Asymmetric dimethylarginine (ADMA)CadmiumEndothelial dysfunction<p dir="ltr">Cadmium (Cd) is a naturally occurring toxic heavy metal with no known essential biological functions. Exposure to Cd increases the risk of cardiovascular disease by disrupting vascular homeostasis at the endothelium. The aim of the study was to evaluate the effect of chronic low-dose Cd on vascular structure and function. Fifty adult male Sprague Dawley rats were grouped and assigned to one of two treatments for 14 weeks. The control group received normal water for 14 weeks while the Cd-treated group received 15 mg Cd/kg B.W. as CdCl<sub>2</sub> in water for 10 weeks. A subset of the Cd-treated group received 15 mg Cd/kg B.W. as CdCl<sub>2</sub> in water for 10 weeks followed by 4 weeks of normal water. Results show an overall decline in vascular function and structure. Withdrawal of Cd treatment showed a considerable restoration of vascular structure and vasorelaxation function. Additionally, asymmetric dimethylarginine (ADMA) bioavailability was found to be lowered over time. Interestingly, the expression of eNOS in the Cd-treated group was found to be significantly elevated during the exposure by more than 3-fold in comparison with that in the control group. This protein expression was similar to the control group after the withdrawal of Cd treatment. Taken together, the results suggest that ADMA, an eNOS inhibitor, may play a role in altering endothelial function in the presence of cadmium. In conclusion, the findings indicate that even at low doses, Cd leads to endothelial dysfunction mediated by ADMA.</p><h2>Other Information</h2><p dir="ltr">Published in: Environmental Science and Pollution Research<br>License: <a href="https://creativecommons.org/licenses/by/4.0" target="_blank">https://creativecommons.org/licenses/by/4.0</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.1007/s11356-020-08116-5" target="_blank">http://dx.doi.org/10.1007/s11356-020-08116-5</a></p>2020-03-02T18:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1007/s11356-020-08116-5https://figshare.com/articles/journal_contribution/Cadmium-induced_endothelial_dysfunction_mediated_by_asymmetric_dimethylarginine/21597543CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/215975432020-03-02T18:00:00Z |
| spellingShingle | Cadmium-induced endothelial dysfunction mediated by asymmetric dimethylarginine Hamda A. Al-Naemi (14151675) Biomedical and clinical sciences Cardiovascular medicine and haematology Pharmacology and pharmaceutical sciences Environmental engineering Pollution and contamination Endothelial nitric oxide synthase (eNOS) Asymmetric dimethylarginine (ADMA) Cadmium Endothelial dysfunction |
| status_str | publishedVersion |
| title | Cadmium-induced endothelial dysfunction mediated by asymmetric dimethylarginine |
| title_full | Cadmium-induced endothelial dysfunction mediated by asymmetric dimethylarginine |
| title_fullStr | Cadmium-induced endothelial dysfunction mediated by asymmetric dimethylarginine |
| title_full_unstemmed | Cadmium-induced endothelial dysfunction mediated by asymmetric dimethylarginine |
| title_short | Cadmium-induced endothelial dysfunction mediated by asymmetric dimethylarginine |
| title_sort | Cadmium-induced endothelial dysfunction mediated by asymmetric dimethylarginine |
| topic | Biomedical and clinical sciences Cardiovascular medicine and haematology Pharmacology and pharmaceutical sciences Environmental engineering Pollution and contamination Endothelial nitric oxide synthase (eNOS) Asymmetric dimethylarginine (ADMA) Cadmium Endothelial dysfunction |