Qatari Genotype May Contribute to Complications in Type 2 Diabetes
<p dir="ltr">Objective. There is increasing evidence of a strong genetic component in type 2 diabetes (T2DM) that may contribute to diabetes complications. Given the high prevalence of diabetes with its associated complications in the Middle East, we sought to determine if the genoty...
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| مؤلفون آخرون: | , , , , , |
| منشور في: |
2020
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| _version_ | 1864513515878875136 |
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| author | Youssra Dakroury (9991407) |
| author2 | Stephen L. Atkin (6684368) Soha R. Dargham (3613250) Amal Robay (3158892) Juan Rodriguez-Flores (3497981) Ronald G. Crystal (8813645) Alexandra E. Butler (6189536) |
| author2_role | author author author author author author |
| author_facet | Youssra Dakroury (9991407) Stephen L. Atkin (6684368) Soha R. Dargham (3613250) Amal Robay (3158892) Juan Rodriguez-Flores (3497981) Ronald G. Crystal (8813645) Alexandra E. Butler (6189536) |
| author_role | author |
| dc.creator.none.fl_str_mv | Youssra Dakroury (9991407) Stephen L. Atkin (6684368) Soha R. Dargham (3613250) Amal Robay (3158892) Juan Rodriguez-Flores (3497981) Ronald G. Crystal (8813645) Alexandra E. Butler (6189536) |
| dc.date.none.fl_str_mv | 2020-06-10T06:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1155/2020/6356973 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Qatari_Genotype_May_Contribute_to_Complications_in_Type_2_Diabetes/25836112 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Arab Continental Ancestry Group African Continental Ancestry Group Asian Continental Ancestry Group Type 2 Diabetes Mellitus Cells Diabetes Complications Diabetic Neuropathies Diabetic Retinopathy Genetic Predisposition to Disease Genotype Hypertension Middle Aged Polymorphism, Single Nucleotide |
| dc.title.none.fl_str_mv | Qatari Genotype May Contribute to Complications in Type 2 Diabetes |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">Objective. There is increasing evidence of a strong genetic component in type 2 diabetes (T2DM) that may contribute to diabetes complications. Given the high prevalence of diabetes with its associated complications in the Middle East, we sought to determine if the genotype within a Middle East population may be contributory. Therefore, three genotype-based Qatari ancestral groups, Q1 Arab Bedouin, Q2 Asian/Persian, and Q3 sub-Saharan African, with a fourth admixed group were correlated with T2DM prevalence and its complications to determine if they differed between the 4 Qatari ancestries, particularly for the SLMAP allele-associated diabetic retinopathy. Methods. In this cross-sectional study, 398 Qatari subjects, 220 with and 178 without T2DM, were genotyped by Affymetrix 500k SNP arrays. Ancestry was correlated with diabetes complications. Results. 398 subjects were included, the mean age was 49.8 years, and 56.8% were male. The genotype-based ancestry and T2DM prevalence were as follows: 164 (41.2%) with ancestry Q1, 60.4% with T2DM; 149 (37.4%) with ancestry Q2, 49.7% with T2DM; 31 (7.8%) with ancestry Q3, 61.3% with T2DM; and 54 (13.6%) with “admixed” ancestry, 51.9% with T2DM. For patients with diabetes, hypertension (p<0.035) and retinopathy (p<0.016) were greater in the Q3 ancestry. Conclusion. These data suggest that the genotype may contribute to complication risk, as exemplified by the increase in hypertension and retinopathy in the Q3 ancestry, though the SLMAP allele was not implicated; however, diabetes prevalence did not differ between the four Qatari ancestries.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Diabetes Research<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1155/2020/6356973" target="_blank">https://dx.doi.org/10.1155/2020/6356973</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_502c28be816dca99ebebe583ce8e1b90 |
| identifier_str_mv | 10.1155/2020/6356973 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/25836112 |
| publishDate | 2020 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Qatari Genotype May Contribute to Complications in Type 2 DiabetesYoussra Dakroury (9991407)Stephen L. Atkin (6684368)Soha R. Dargham (3613250)Amal Robay (3158892)Juan Rodriguez-Flores (3497981)Ronald G. Crystal (8813645)Alexandra E. Butler (6189536)Biological sciencesGeneticsBiomedical and clinical sciencesClinical sciencesArab Continental Ancestry GroupAfrican Continental Ancestry GroupAsian Continental Ancestry GroupType 2 Diabetes Mellitus CellsDiabetes ComplicationsDiabetic NeuropathiesDiabetic RetinopathyGenetic Predisposition to DiseaseGenotypeHypertensionMiddle AgedPolymorphism, Single Nucleotide<p dir="ltr">Objective. There is increasing evidence of a strong genetic component in type 2 diabetes (T2DM) that may contribute to diabetes complications. Given the high prevalence of diabetes with its associated complications in the Middle East, we sought to determine if the genotype within a Middle East population may be contributory. Therefore, three genotype-based Qatari ancestral groups, Q1 Arab Bedouin, Q2 Asian/Persian, and Q3 sub-Saharan African, with a fourth admixed group were correlated with T2DM prevalence and its complications to determine if they differed between the 4 Qatari ancestries, particularly for the SLMAP allele-associated diabetic retinopathy. Methods. In this cross-sectional study, 398 Qatari subjects, 220 with and 178 without T2DM, were genotyped by Affymetrix 500k SNP arrays. Ancestry was correlated with diabetes complications. Results. 398 subjects were included, the mean age was 49.8 years, and 56.8% were male. The genotype-based ancestry and T2DM prevalence were as follows: 164 (41.2%) with ancestry Q1, 60.4% with T2DM; 149 (37.4%) with ancestry Q2, 49.7% with T2DM; 31 (7.8%) with ancestry Q3, 61.3% with T2DM; and 54 (13.6%) with “admixed” ancestry, 51.9% with T2DM. For patients with diabetes, hypertension (p<0.035) and retinopathy (p<0.016) were greater in the Q3 ancestry. Conclusion. These data suggest that the genotype may contribute to complication risk, as exemplified by the increase in hypertension and retinopathy in the Q3 ancestry, though the SLMAP allele was not implicated; however, diabetes prevalence did not differ between the four Qatari ancestries.</p><h2>Other Information</h2><p dir="ltr">Published in: Journal of Diabetes Research<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1155/2020/6356973" target="_blank">https://dx.doi.org/10.1155/2020/6356973</a></p>2020-06-10T06:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1155/2020/6356973https://figshare.com/articles/journal_contribution/Qatari_Genotype_May_Contribute_to_Complications_in_Type_2_Diabetes/25836112CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/258361122020-06-10T06:00:00Z |
| spellingShingle | Qatari Genotype May Contribute to Complications in Type 2 Diabetes Youssra Dakroury (9991407) Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Arab Continental Ancestry Group African Continental Ancestry Group Asian Continental Ancestry Group Type 2 Diabetes Mellitus Cells Diabetes Complications Diabetic Neuropathies Diabetic Retinopathy Genetic Predisposition to Disease Genotype Hypertension Middle Aged Polymorphism, Single Nucleotide |
| status_str | publishedVersion |
| title | Qatari Genotype May Contribute to Complications in Type 2 Diabetes |
| title_full | Qatari Genotype May Contribute to Complications in Type 2 Diabetes |
| title_fullStr | Qatari Genotype May Contribute to Complications in Type 2 Diabetes |
| title_full_unstemmed | Qatari Genotype May Contribute to Complications in Type 2 Diabetes |
| title_short | Qatari Genotype May Contribute to Complications in Type 2 Diabetes |
| title_sort | Qatari Genotype May Contribute to Complications in Type 2 Diabetes |
| topic | Biological sciences Genetics Biomedical and clinical sciences Clinical sciences Arab Continental Ancestry Group African Continental Ancestry Group Asian Continental Ancestry Group Type 2 Diabetes Mellitus Cells Diabetes Complications Diabetic Neuropathies Diabetic Retinopathy Genetic Predisposition to Disease Genotype Hypertension Middle Aged Polymorphism, Single Nucleotide |