Akkermansia, a Possible Microbial Marker for Poor Glycemic Control in Qataris Children Consuming Arabic Diet—A Pilot Study on Pediatric T1DM in Qatar
<p dir="ltr">In Qatar, Type 1 Diabetes mellitus (T1DM) is one of the most prevalent disorders. This study aimed to explore the gut microbiome’s relation to the continuous subcutaneous insulin infusion (CSII) therapy, dietary habits, and the HbA1c level in the pediatric T1DM subjects...
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2021
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| _version_ | 1864513559491248128 |
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| author | Arun Prasath Lakshmanan (16444663) |
| author2 | Amira Kohil (15257285) Farah El Assadi (16444666) Sara Al Zaidan (12474501) Shaikha Al Abduljabbar (11304073) Dhinoth Kumar Bangarusamy (13238) Fawziya Al Khalaf (9303667) Goran Petrovski (129836) Annalisa Terranegra (3486953) |
| author2_role | author author author author author author author author |
| author_facet | Arun Prasath Lakshmanan (16444663) Amira Kohil (15257285) Farah El Assadi (16444666) Sara Al Zaidan (12474501) Shaikha Al Abduljabbar (11304073) Dhinoth Kumar Bangarusamy (13238) Fawziya Al Khalaf (9303667) Goran Petrovski (129836) Annalisa Terranegra (3486953) |
| author_role | author |
| dc.creator.none.fl_str_mv | Arun Prasath Lakshmanan (16444663) Amira Kohil (15257285) Farah El Assadi (16444666) Sara Al Zaidan (12474501) Shaikha Al Abduljabbar (11304073) Dhinoth Kumar Bangarusamy (13238) Fawziya Al Khalaf (9303667) Goran Petrovski (129836) Annalisa Terranegra (3486953) |
| dc.date.none.fl_str_mv | 2021-03-04T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.3390/nu13030836 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/_em_Akkermansia_em_a_Possible_Microbial_Marker_for_Poor_Glycemic_Control_in_Qataris_Children_Consuming_Arabic_Diet_A_Pilot_Study_on_Pediatric_T1DM_in_Qatar/23578353 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Agricultural, veterinary and food sciences Food sciences Biomedical and clinical sciences Nutrition and dietetics Paediatrics Akkermansia T1DM Arabic diet ethnicity HbA1c CSII therapy |
| dc.title.none.fl_str_mv | Akkermansia, a Possible Microbial Marker for Poor Glycemic Control in Qataris Children Consuming Arabic Diet—A Pilot Study on Pediatric T1DM in Qatar |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">In Qatar, Type 1 Diabetes mellitus (T1DM) is one of the most prevalent disorders. This study aimed to explore the gut microbiome’s relation to the continuous subcutaneous insulin infusion (CSII) therapy, dietary habits, and the HbA1c level in the pediatric T1DM subjects in Qatar. We recruited 28 T1DM subjects with an average age of 10.5 ± 3.53 years. The stool sample was used to measure microbial composition by 16s rDNA sequencing method. The results have revealed that the subjects who had undergone CSII therapy had increased microbial diversity and genus <i>Akkermansia</i> was significantly enriched in the subjects without CSII therapy. Moreover, genus <i>Akkermansia</i> was higher in the subjects with poor glycemic control (HbA1c > 7.5%). When we classified the subjects based on dietary patterns and nationality, <i>Akkermansia</i> was significantly enriched in Qataris subjects without the CSII therapy consuming Arabic diet than expatriates living in Qatar and eating a Western/mixed diet. Thus, this pilot study showed that abundance of <i>Akkermansia</i> is dependent on the Arabic diet only in poorly controlled Qataris T1DM patients, opening new routes to personalized treatment for T1DM in Qataris pediatric subjects. Further comprehensive studies on the relation between the Arabic diet, ethnicity, and <i>Akkermansia</i> are warranted to confirm this preliminary finding.</p><h2>Other Information</h2><p dir="ltr">Published in: Nutrients<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.3390/nu13030836" target="_blank">http://dx.doi.org/10.3390/nu13030836</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_505eba2c97a9a9f4b5c5e4f3d3006d36 |
| identifier_str_mv | 10.3390/nu13030836 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/23578353 |
| publishDate | 2021 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Akkermansia, a Possible Microbial Marker for Poor Glycemic Control in Qataris Children Consuming Arabic Diet—A Pilot Study on Pediatric T1DM in QatarArun Prasath Lakshmanan (16444663)Amira Kohil (15257285)Farah El Assadi (16444666)Sara Al Zaidan (12474501)Shaikha Al Abduljabbar (11304073)Dhinoth Kumar Bangarusamy (13238)Fawziya Al Khalaf (9303667)Goran Petrovski (129836)Annalisa Terranegra (3486953)Agricultural, veterinary and food sciencesFood sciencesBiomedical and clinical sciencesNutrition and dieteticsPaediatricsAkkermansiaT1DMArabic dietethnicityHbA1cCSII therapy<p dir="ltr">In Qatar, Type 1 Diabetes mellitus (T1DM) is one of the most prevalent disorders. This study aimed to explore the gut microbiome’s relation to the continuous subcutaneous insulin infusion (CSII) therapy, dietary habits, and the HbA1c level in the pediatric T1DM subjects in Qatar. We recruited 28 T1DM subjects with an average age of 10.5 ± 3.53 years. The stool sample was used to measure microbial composition by 16s rDNA sequencing method. The results have revealed that the subjects who had undergone CSII therapy had increased microbial diversity and genus <i>Akkermansia</i> was significantly enriched in the subjects without CSII therapy. Moreover, genus <i>Akkermansia</i> was higher in the subjects with poor glycemic control (HbA1c > 7.5%). When we classified the subjects based on dietary patterns and nationality, <i>Akkermansia</i> was significantly enriched in Qataris subjects without the CSII therapy consuming Arabic diet than expatriates living in Qatar and eating a Western/mixed diet. Thus, this pilot study showed that abundance of <i>Akkermansia</i> is dependent on the Arabic diet only in poorly controlled Qataris T1DM patients, opening new routes to personalized treatment for T1DM in Qataris pediatric subjects. Further comprehensive studies on the relation between the Arabic diet, ethnicity, and <i>Akkermansia</i> are warranted to confirm this preliminary finding.</p><h2>Other Information</h2><p dir="ltr">Published in: Nutrients<br>License: <a href="https://creativecommons.org/licenses/by/4.0/" target="_blank">https://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="http://dx.doi.org/10.3390/nu13030836" target="_blank">http://dx.doi.org/10.3390/nu13030836</a></p>2021-03-04T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.3390/nu13030836https://figshare.com/articles/journal_contribution/_em_Akkermansia_em_a_Possible_Microbial_Marker_for_Poor_Glycemic_Control_in_Qataris_Children_Consuming_Arabic_Diet_A_Pilot_Study_on_Pediatric_T1DM_in_Qatar/23578353CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/235783532021-03-04T00:00:00Z |
| spellingShingle | Akkermansia, a Possible Microbial Marker for Poor Glycemic Control in Qataris Children Consuming Arabic Diet—A Pilot Study on Pediatric T1DM in Qatar Arun Prasath Lakshmanan (16444663) Agricultural, veterinary and food sciences Food sciences Biomedical and clinical sciences Nutrition and dietetics Paediatrics Akkermansia T1DM Arabic diet ethnicity HbA1c CSII therapy |
| status_str | publishedVersion |
| title | Akkermansia, a Possible Microbial Marker for Poor Glycemic Control in Qataris Children Consuming Arabic Diet—A Pilot Study on Pediatric T1DM in Qatar |
| title_full | Akkermansia, a Possible Microbial Marker for Poor Glycemic Control in Qataris Children Consuming Arabic Diet—A Pilot Study on Pediatric T1DM in Qatar |
| title_fullStr | Akkermansia, a Possible Microbial Marker for Poor Glycemic Control in Qataris Children Consuming Arabic Diet—A Pilot Study on Pediatric T1DM in Qatar |
| title_full_unstemmed | Akkermansia, a Possible Microbial Marker for Poor Glycemic Control in Qataris Children Consuming Arabic Diet—A Pilot Study on Pediatric T1DM in Qatar |
| title_short | Akkermansia, a Possible Microbial Marker for Poor Glycemic Control in Qataris Children Consuming Arabic Diet—A Pilot Study on Pediatric T1DM in Qatar |
| title_sort | Akkermansia, a Possible Microbial Marker for Poor Glycemic Control in Qataris Children Consuming Arabic Diet—A Pilot Study on Pediatric T1DM in Qatar |
| topic | Agricultural, veterinary and food sciences Food sciences Biomedical and clinical sciences Nutrition and dietetics Paediatrics Akkermansia T1DM Arabic diet ethnicity HbA1c CSII therapy |