Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications
<p dir="ltr">The global burden of breast cancer (BC) is increasing significantly. This trend is caused by several factors such as late diagnosis, limited treatment options for certain BC subtypes, drug resistance which all lead to poor clinical outcomes. Recent research has reported...
محفوظ في:
| المؤلف الرئيسي: | |
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| مؤلفون آخرون: | , , , , , , , , |
| منشور في: |
2022
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إضافة وسم
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| _version_ | 1864513559437770752 |
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| author | Gulab Sher (12984698) |
| author2 | Nadia Aziz Salman (17058033) Abdul Q. Khan (14153247) Kirti S. Prabhu (4246144) Afsheen Raza (492657) Michal Kulinski (3520070) Said Dermime (79420) Mohammad Haris (564809) Kulsoom Junejo (9327448) Shahab Uddin (154400) |
| author2_role | author author author author author author author author author |
| author_facet | Gulab Sher (12984698) Nadia Aziz Salman (17058033) Abdul Q. Khan (14153247) Kirti S. Prabhu (4246144) Afsheen Raza (492657) Michal Kulinski (3520070) Said Dermime (79420) Mohammad Haris (564809) Kulsoom Junejo (9327448) Shahab Uddin (154400) |
| author_role | author |
| dc.creator.none.fl_str_mv | Gulab Sher (12984698) Nadia Aziz Salman (17058033) Abdul Q. Khan (14153247) Kirti S. Prabhu (4246144) Afsheen Raza (492657) Michal Kulinski (3520070) Said Dermime (79420) Mohammad Haris (564809) Kulsoom Junejo (9327448) Shahab Uddin (154400) |
| dc.date.none.fl_str_mv | 2022-08-25T00:00:00Z |
| dc.identifier.none.fl_str_mv | 10.1016/j.semcancer.2020.08.009 |
| dc.relation.none.fl_str_mv | https://figshare.com/articles/journal_contribution/Epigenetic_and_breast_cancer_therapy_Promising_diagnostic_and_therapeutic_applications/24210645 |
| dc.rights.none.fl_str_mv | CC BY 4.0 info:eu-repo/semantics/openAccess |
| dc.subject.none.fl_str_mv | Biomedical and clinical sciences Oncology and carcinogenesis Epigenetics Breast cancer DNA methylation Epigenetic drugs Biomarkers |
| dc.title.none.fl_str_mv | Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications |
| dc.type.none.fl_str_mv | Text Journal contribution info:eu-repo/semantics/publishedVersion text contribution to journal |
| description | <p dir="ltr">The global burden of breast cancer (BC) is increasing significantly. This trend is caused by several factors such as late diagnosis, limited treatment options for certain BC subtypes, drug resistance which all lead to poor clinical outcomes. Recent research has reported the role of epigenetic alterations in the mechanism of BC pathogenesis and its hallmarks include drug resistance and stemness features. The understanding of these modifications and their significance in the management of BC carcinogenesis is challenging and requires further attention. Nevertheless, it promises to provide novel insight needed for utilizing these alterations as potential diagnostic, prognostic markers, predict treatment efficacy, as well as therapeutic agents. This highlights the importance of continuing research development to further advance the existing knowledge on epigenetics and BC carcinogenesis to overcome the current challenges. Hence, this review aims to shed light and discuss the current state of epigenetics research in the diagnosis and management of BC.</p><h2>Other Information</h2><p dir="ltr">Published in: Seminars in Cancer Biology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.semcancer.2020.08.009" target="_blank">https://dx.doi.org/10.1016/j.semcancer.2020.08.009</a></p> |
| eu_rights_str_mv | openAccess |
| id | Manara2_507ffbf782294568d0c23de4064eb8e8 |
| identifier_str_mv | 10.1016/j.semcancer.2020.08.009 |
| network_acronym_str | Manara2 |
| network_name_str | Manara2 |
| oai_identifier_str | oai:figshare.com:article/24210645 |
| publishDate | 2022 |
| repository.mail.fl_str_mv | |
| repository.name.fl_str_mv | |
| repository_id_str | |
| rights_invalid_str_mv | CC BY 4.0 |
| spelling | Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applicationsGulab Sher (12984698)Nadia Aziz Salman (17058033)Abdul Q. Khan (14153247)Kirti S. Prabhu (4246144)Afsheen Raza (492657)Michal Kulinski (3520070)Said Dermime (79420)Mohammad Haris (564809)Kulsoom Junejo (9327448)Shahab Uddin (154400)Biomedical and clinical sciencesOncology and carcinogenesisEpigeneticsBreast cancerDNA methylationEpigenetic drugsBiomarkers<p dir="ltr">The global burden of breast cancer (BC) is increasing significantly. This trend is caused by several factors such as late diagnosis, limited treatment options for certain BC subtypes, drug resistance which all lead to poor clinical outcomes. Recent research has reported the role of epigenetic alterations in the mechanism of BC pathogenesis and its hallmarks include drug resistance and stemness features. The understanding of these modifications and their significance in the management of BC carcinogenesis is challenging and requires further attention. Nevertheless, it promises to provide novel insight needed for utilizing these alterations as potential diagnostic, prognostic markers, predict treatment efficacy, as well as therapeutic agents. This highlights the importance of continuing research development to further advance the existing knowledge on epigenetics and BC carcinogenesis to overcome the current challenges. Hence, this review aims to shed light and discuss the current state of epigenetics research in the diagnosis and management of BC.</p><h2>Other Information</h2><p dir="ltr">Published in: Seminars in Cancer Biology<br>License: <a href="http://creativecommons.org/licenses/by/4.0/" target="_blank">http://creativecommons.org/licenses/by/4.0/</a><br>See article on publisher's website: <a href="https://dx.doi.org/10.1016/j.semcancer.2020.08.009" target="_blank">https://dx.doi.org/10.1016/j.semcancer.2020.08.009</a></p>2022-08-25T00:00:00ZTextJournal contributioninfo:eu-repo/semantics/publishedVersiontextcontribution to journal10.1016/j.semcancer.2020.08.009https://figshare.com/articles/journal_contribution/Epigenetic_and_breast_cancer_therapy_Promising_diagnostic_and_therapeutic_applications/24210645CC BY 4.0info:eu-repo/semantics/openAccessoai:figshare.com:article/242106452022-08-25T00:00:00Z |
| spellingShingle | Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications Gulab Sher (12984698) Biomedical and clinical sciences Oncology and carcinogenesis Epigenetics Breast cancer DNA methylation Epigenetic drugs Biomarkers |
| status_str | publishedVersion |
| title | Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications |
| title_full | Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications |
| title_fullStr | Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications |
| title_full_unstemmed | Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications |
| title_short | Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications |
| title_sort | Epigenetic and breast cancer therapy: Promising diagnostic and therapeutic applications |
| topic | Biomedical and clinical sciences Oncology and carcinogenesis Epigenetics Breast cancer DNA methylation Epigenetic drugs Biomarkers |